ID   A0A2Y9SZ29_PHYMC        Unreviewed;      1625 AA.
AC   A0A2Y9SZ29;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=THO complex subunit 2 {ECO:0000256|ARBA:ARBA00019596};
GN   Name=THOC2 {ECO:0000313|RefSeq:XP_023983931.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023983931.1};
RN   [1] {ECO:0000313|RefSeq:XP_023983931.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_023983931.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBUNIT: Component of the THO complex, which is composed of THOC1,
CC       THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least
CC       ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the
CC       transcription/export (TREX) complex which seems to have a dynamic
CC       structure involving ATP-dependent remodeling. Interacts with THOC1,
CC       POLDIP3 and ZC3H11A. {ECO:0000256|ARBA:ARBA00025995}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the THOC2 family.
CC       {ECO:0000256|ARBA:ARBA00007857}.
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DR   RefSeq; XP_023983931.1; XM_024128163.2.
DR   KEGG; pcad:102973141; -.
DR   OrthoDB; 179356at2759; -.
DR   Proteomes; UP000248484; Chromosome 21.
DR   GO; GO:0000347; C:THO complex; IEA:InterPro.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   InterPro; IPR040007; Tho2.
DR   InterPro; IPR021418; THO_THOC2_C.
DR   InterPro; IPR021726; THO_THOC2_N.
DR   InterPro; IPR032302; THOC2_N.
DR   PANTHER; PTHR21597:SF0; THO COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR21597; THO2 PROTEIN; 1.
DR   Pfam; PF11262; Tho2; 1.
DR   Pfam; PF11732; Thoc2; 1.
DR   Pfam; PF16134; THOC2_N; 2.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT   DOMAIN          11..419
FT                   /note="THO complex subunit 2 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16134"
FT   DOMAIN          420..566
FT                   /note="THO complex subunit 2 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16134"
FT   DOMAIN          568..643
FT                   /note="THO complex subunitTHOC2 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11732"
FT   DOMAIN          873..1173
FT                   /note="THO complex subunitTHOC2 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11262"
SQ   SEQUENCE   1625 AA;  186255 MW;  4200B05CB85C678E CRC64;
     MAAASVVVPV EWIKNWEKSG RGEFLHLCRI LSENKSHDSS TYRDFQQALY ELSYHVIKGN
     LKHEQASNVL NDISEFREDM PSILADVFCI LDIETNCLEE KSKRDYFTQL VLACLYLVSD
     TVLKERLDPE TLESLGLIKQ SQQFNQKSVK IKTKLFYKQQ KFNLLREENE GYAKLIAELG
     QDLSGNITSD LILENIKSLI GCFNLDPNRV LDVILEVFEC RPEHDDFFIS LLESYMSMCE
     PQTLCHILGF KFKFYQEPNG ETPSSLYRVA AVLLQFNLID LDDLYVHLLP ADNCIMDEHK
     REIVEAKQIV RKLTMVVLSS DKIDEREKEK EKEEEKVEKP PDNQKLGLLE ALLKIGDWQH
     AQNIMDQMPP YYAASHKLIA LAICKLIHIT IEPLYRRVGV PKGAKGSPVN ALQNKRAPKQ
     AESFEDLRRD VFNMFCYLGP HLSHDPILFA KVVRIGKSFM KEFQSDGSKQ EDKEKTEVIL
     SCLLSITDQV LLPSLSLMDC NACMSEELWG MFKTFPYQHR YRLYGQWKNE TYNSHPLLVK
     VKAQTIDRAK YIMKRLTKEN VKPSGRQIGK LSHSNPTILF DYILSQIQKY DNLITPVVDS
     LKYLTSLNYD VLAYCIIEAL ANPEKERMKH DDTTISSWLQ SLASFCGAVF RKYPIDLAGL
     LQYVANQLKA GKSFDLLILK EVVQKMAGIE ITEEMTMEQL EAMTGGEQLK AEGGYFGQIR
     NTKKSSQRLK DALLDHDLAL PLCLLMAQQR NGVIFQEGGE KHLKLVGKLY DQCHDTLVQF
     GGFLASNLST EDYIKRVPSI DVLCNEFHTP HDAAFFLSRP MYAHHISSKY DELKKSEKGS
     KQQHKVHKYI TSCEMVMAPV HEAVVSLHVS KVWDDISPQF YATFWSLTMY DLAVPHTSYE
     REVNKLKVQM KAIDDNQEMP PNKKKKEKER CTALQDKLLE EEKKQMEHVQ RVLQRLKLEK
     DNWLLAKSTK NETITKFLQL CIFPRCIFSA IDAVYCARFV ELVHQQKTPN FSTLLCYDRV
     FSDIIYTVAS CTENEASRYG RFLCCMLETV TRWHSDRATY EKECGNYPGF LTILRATGFD
     GGNKADQLDY ENFRHVVHKW HYKLTKASVH CLETGEYTHI RNILIVLTKI LPWYPKVLNL
     GQALERRVHK ICQEEKEKRP DLYALAMGYS GQLKSRKSYM IPENEFHHKD PPPRNAVASV
     QNGPGGGPSS SSVGSASKSD ESSTEETDKS RERSQCGVKA VNKASSATPK GNSSNGNSGS
     NSSKAVKEND KEKGKEKEKE KKEKTPATTP EARVLGKDGK EKPKEERPSK DEKARETKER
     TPKSDKEKEK FKKEEKAKDE KFKTTVPNVE SKSTQEKERE KEPSRERDIA KEMKSKENVK
     GGEKTPVSGS LKSPVPRSDI AEPEREQKRR KIDTYPSPSH SSTVKLVYFQ VTAILPKVPL
     GSENYASSPV ISIHFLQDSL IELKESSAKL YINHTPPPLS KSKEREMDKK DLDKSRERSR
     EREKKDEKDR KERKRDHSNN DREVPPDLTK RRKEENGTMG VSKHKSESPC ESPYPNEKDK
     EKNKSKSSGK EKGGDSFKSE KMDKISSGGK KESRHDKEKI EKKEKRDSSG GKEEKKHHKS
     SDKHR
//