ID   A0A2Y9T2Z3_PHYMC        Unreviewed;       393 AA.
AC   A0A2Y9T2Z3;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=LOW QUALITY PROTEIN: pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial {ECO:0000313|RefSeq:XP_023982464.1};
GN   Name=PDHA2 {ECO:0000313|RefSeq:XP_023982464.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023982464.1};
RN   [1] {ECO:0000313|RefSeq:XP_023982464.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_023982464.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   RefSeq; XP_023982464.1; XM_024126696.1.
DR   KEGG; pcad:102986441; -.
DR   InParanoid; A0A2Y9T2Z3; -.
DR   OrthoDB; 4914618at2759; -.
DR   Proteomes; UP000248484; Chromosome 7.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pyruvate {ECO:0000313|RefSeq:XP_023982464.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          71..363
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   393 AA;  43324 MW;  BF1FDE3D3640989C CRC64;
     MRKMLAAAVS SVLSVVTQKP ANRVLVASCN YSNDATFEIK KSPKCDLYRL EEGPPVTAVL
     TREDGLKYYR MMQTVRRMEL KADQLKKQKF FRGFCHLCDG QDACCVGLEA GLNPTDHVIA
     SCRAHGLCCT RGLSVPSIFA ELTGRRGGCA EGEGGSMHMX ADNFYGDNGI VGSQGPPGAG
     IALACKYKGD NEVCXTLHGN GAANQGQISE AYNMAAVWHL PCIFICENNR YGMGTSVERA
     AANTDYYKRG NFIPGLRVDG MEVLCVREAT KVAADYCRSG KGPILMELLT YHYHGHSMSH
     PGISYRTREE VQNLXKSHPI MLLKGKMVNN KLASIEELKE IDAEVRKEID AAAQFAITDP
     EPPLEELSRH IYSSNPPLEI RRANRWIRFK SVS
//