ID A0A2Y9T4D5_PHYMC Unreviewed; 838 AA.
AC A0A2Y9T4D5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Zinc fingers and homeoboxes protein 2 {ECO:0000313|RefSeq:XP_023985193.1, ECO:0000313|RefSeq:XP_028356227.1};
GN Name=ZHX2 {ECO:0000313|RefSeq:XP_023985193.1,
GN ECO:0000313|RefSeq:XP_028356227.1, ECO:0000313|RefSeq:XP_028356228.1,
GN ECO:0000313|RefSeq:XP_028356230.1, ECO:0000313|RefSeq:XP_028356231.1,
GN ECO:0000313|RefSeq:XP_028356232.1, ECO:0000313|RefSeq:XP_028356233.1,
GN ECO:0000313|RefSeq:XP_028356235.1, ECO:0000313|RefSeq:XP_028356236.1,
GN ECO:0000313|RefSeq:XP_028356237.1, ECO:0000313|RefSeq:XP_054946995.1,
GN ECO:0000313|RefSeq:XP_054946996.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023985193.1};
RN [1] {ECO:0000313|RefSeq:XP_023985193.1, ECO:0000313|RefSeq:XP_028356227.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023985193.1,
RC ECO:0000313|RefSeq:XP_028356227.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the ZHX family. {ECO:0000256|ARBA:ARBA00007440}.
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DR RefSeq; XP_007126135.1; XM_007126073.1.
DR RefSeq; XP_023985193.1; XM_024129425.3.
DR RefSeq; XP_028356227.1; XM_028500426.2.
DR RefSeq; XP_028356228.1; XM_028500427.2.
DR RefSeq; XP_028356230.1; XM_028500429.2.
DR RefSeq; XP_028356231.1; XM_028500430.2.
DR RefSeq; XP_028356232.1; XM_028500431.2.
DR RefSeq; XP_028356233.1; XM_028500432.2.
DR RefSeq; XP_028356235.1; XM_028500434.2.
DR RefSeq; XP_028356236.1; XM_028500435.2.
DR RefSeq; XP_028356237.1; XM_028500436.2.
DR RefSeq; XP_054946995.1; XM_055091020.1.
DR RefSeq; XP_054946996.1; XM_055091021.1.
DR STRING; 9755.ENSPCTP00005014710; -.
DR Ensembl; ENSPCTT00005016276; ENSPCTP00005014710; ENSPCTG00005010562.
DR KEGG; pcad:102973454; -.
DR OrthoDB; 5350395at2759; -.
DR Proteomes; UP000248484; Chromosome 15.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:Ensembl.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0060040; P:retinal bipolar neuron differentiation; IEA:Ensembl.
DR GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 4.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 4.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR041057; ZHX_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR15467:SF5; ZINC FINGERS AND HOMEOBOXES PROTEIN 2; 1.
DR PANTHER; PTHR15467; ZINC-FINGERS AND HOMEOBOXES RELATED; 1.
DR Pfam; PF00046; Homeodomain; 3.
DR Pfam; PF18387; zf_C2H2_ZHX; 1.
DR SMART; SM00389; HOX; 4.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 4.
DR PROSITE; PS50071; HOMEOBOX_2; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 110..138
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 447..497
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 537..587
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 636..686
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 449..498
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 539..588
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 638..687
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..436
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..752
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 838 AA; 92080 MW; 4F3FEBB93F4B4A0B CRC64;
MASKRKSTTP CMVRASQVVE QDVPEEGDRA KEKGIGTPQP EMAKDPWAAE PENASKENEV
IEVKSTGENQ SKKLQGGYEC KYCPYSTQNL NEFTEHVDMQ HPNVILNPLY VCAECNFTTK
KYDSLSDHNS KFHPGETNFK LKLIKRNNQT VLEQSVEATN RITSVTTSGP GSGDNDPGIS
VSKTPIMKPG KPKADAKKVP KKPEEAAPEN HVEGTTRLVT DAAEILSRLG GVELLQDTLG
HVMPSVQLPP NINLVPKVPV PLNTTKYNSA LDTNATMINS FNKFPYPTQA ELSWLTAASK
HPEEHIRIWF ATQRLKHGIS WSPEEVEEAR KKMFNGTIQS VPPTITVLPA QLAPTKMSQP
ILQTALPCQI LGQTSLVLTQ VTSGPTTVSC SPITLTVAGV TNHGQKRPLV TPQAAPEPKR
PHIAQVPEPP PKVANPSLTP AGDRKKTKEQ IAHLKASFLQ SQFPDDAEVY RLIEVTGLAR
SEIKKWFSDH RYRCQRGIVH ITSESLAKDQ LAIAASRHGR TCHAYPDFAP QKFKEKTQGQ
VKILEDSFLK SSFPTQAELD RLRVETKLSR REIDSWFSER RKLRDSMEQA VLDSMGSSKK
GPDSVAPNGA LSRLDQFSGA QVPSSLPSPS PAITKNQEQV HLLRSTFART QWPTPQEYDQ
LAAKTGLVRT EIVRWFKENR CLLKTGTLKW LEQYQQQRVA DDHGYGALSR KAAKAVVAES
SENGSEGGPR YHKDPKKLCE EDLEKLGPRV KAGGEQARDG LPAKPSEATS DRSEGNSRDG
QGSDGNEESG IVDWVEVTVG EEDAVSDRSD SWSQTATEGA AEPADSDSDS VPAEASQA
//