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Database: UniProt
Entry: A0A2Y9T4D5_PHYMC
LinkDB: A0A2Y9T4D5_PHYMC
Original site: A0A2Y9T4D5_PHYMC 
ID   A0A2Y9T4D5_PHYMC        Unreviewed;       838 AA.
AC   A0A2Y9T4D5;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Zinc fingers and homeoboxes protein 2 {ECO:0000313|RefSeq:XP_023985193.1, ECO:0000313|RefSeq:XP_028356227.1};
GN   Name=ZHX2 {ECO:0000313|RefSeq:XP_023985193.1,
GN   ECO:0000313|RefSeq:XP_028356227.1, ECO:0000313|RefSeq:XP_028356228.1,
GN   ECO:0000313|RefSeq:XP_028356230.1, ECO:0000313|RefSeq:XP_028356231.1,
GN   ECO:0000313|RefSeq:XP_028356232.1, ECO:0000313|RefSeq:XP_028356233.1,
GN   ECO:0000313|RefSeq:XP_028356235.1, ECO:0000313|RefSeq:XP_028356236.1,
GN   ECO:0000313|RefSeq:XP_028356237.1, ECO:0000313|RefSeq:XP_054946995.1,
GN   ECO:0000313|RefSeq:XP_054946996.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023985193.1};
RN   [1] {ECO:0000313|RefSeq:XP_023985193.1, ECO:0000313|RefSeq:XP_028356227.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_023985193.1,
RC   ECO:0000313|RefSeq:XP_028356227.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC   -!- SIMILARITY: Belongs to the ZHX family. {ECO:0000256|ARBA:ARBA00007440}.
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DR   RefSeq; XP_007126135.1; XM_007126073.1.
DR   RefSeq; XP_023985193.1; XM_024129425.3.
DR   RefSeq; XP_028356227.1; XM_028500426.2.
DR   RefSeq; XP_028356228.1; XM_028500427.2.
DR   RefSeq; XP_028356230.1; XM_028500429.2.
DR   RefSeq; XP_028356231.1; XM_028500430.2.
DR   RefSeq; XP_028356232.1; XM_028500431.2.
DR   RefSeq; XP_028356233.1; XM_028500432.2.
DR   RefSeq; XP_028356235.1; XM_028500434.2.
DR   RefSeq; XP_028356236.1; XM_028500435.2.
DR   RefSeq; XP_028356237.1; XM_028500436.2.
DR   RefSeq; XP_054946995.1; XM_055091020.1.
DR   RefSeq; XP_054946996.1; XM_055091021.1.
DR   STRING; 9755.ENSPCTP00005014710; -.
DR   Ensembl; ENSPCTT00005016276; ENSPCTP00005014710; ENSPCTG00005010562.
DR   KEGG; pcad:102973454; -.
DR   OrthoDB; 5350395at2759; -.
DR   Proteomes; UP000248484; Chromosome 15.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:Ensembl.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0060040; P:retinal bipolar neuron differentiation; IEA:Ensembl.
DR   GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 4.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 4.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR041057; ZHX_Znf_C2H2.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR15467:SF5; ZINC FINGERS AND HOMEOBOXES PROTEIN 2; 1.
DR   PANTHER; PTHR15467; ZINC-FINGERS AND HOMEOBOXES RELATED; 1.
DR   Pfam; PF00046; Homeodomain; 3.
DR   Pfam; PF18387; zf_C2H2_ZHX; 1.
DR   SMART; SM00389; HOX; 4.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR   SUPFAM; SSF46689; Homeodomain-like; 4.
DR   PROSITE; PS50071; HOMEOBOX_2; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT   DOMAIN          110..138
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          447..497
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DOMAIN          537..587
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DOMAIN          636..686
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        449..498
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   DNA_BIND        539..588
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   DNA_BIND        638..687
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          405..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          589..611
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          718..838
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..179
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        190..211
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        422..436
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        726..752
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   838 AA;  92080 MW;  4F3FEBB93F4B4A0B CRC64;
     MASKRKSTTP CMVRASQVVE QDVPEEGDRA KEKGIGTPQP EMAKDPWAAE PENASKENEV
     IEVKSTGENQ SKKLQGGYEC KYCPYSTQNL NEFTEHVDMQ HPNVILNPLY VCAECNFTTK
     KYDSLSDHNS KFHPGETNFK LKLIKRNNQT VLEQSVEATN RITSVTTSGP GSGDNDPGIS
     VSKTPIMKPG KPKADAKKVP KKPEEAAPEN HVEGTTRLVT DAAEILSRLG GVELLQDTLG
     HVMPSVQLPP NINLVPKVPV PLNTTKYNSA LDTNATMINS FNKFPYPTQA ELSWLTAASK
     HPEEHIRIWF ATQRLKHGIS WSPEEVEEAR KKMFNGTIQS VPPTITVLPA QLAPTKMSQP
     ILQTALPCQI LGQTSLVLTQ VTSGPTTVSC SPITLTVAGV TNHGQKRPLV TPQAAPEPKR
     PHIAQVPEPP PKVANPSLTP AGDRKKTKEQ IAHLKASFLQ SQFPDDAEVY RLIEVTGLAR
     SEIKKWFSDH RYRCQRGIVH ITSESLAKDQ LAIAASRHGR TCHAYPDFAP QKFKEKTQGQ
     VKILEDSFLK SSFPTQAELD RLRVETKLSR REIDSWFSER RKLRDSMEQA VLDSMGSSKK
     GPDSVAPNGA LSRLDQFSGA QVPSSLPSPS PAITKNQEQV HLLRSTFART QWPTPQEYDQ
     LAAKTGLVRT EIVRWFKENR CLLKTGTLKW LEQYQQQRVA DDHGYGALSR KAAKAVVAES
     SENGSEGGPR YHKDPKKLCE EDLEKLGPRV KAGGEQARDG LPAKPSEATS DRSEGNSRDG
     QGSDGNEESG IVDWVEVTVG EEDAVSDRSD SWSQTATEGA AEPADSDSDS VPAEASQA
//
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