ID A0A2Y9T6C7_PHYMC Unreviewed; 2458 AA.
AC A0A2Y9T6C7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Nuclear receptor corepressor 1 {ECO:0000256|ARBA:ARBA00044171};
GN Name=NCOR1 {ECO:0000313|RefSeq:XP_023983689.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023983689.1};
RN [1] {ECO:0000313|RefSeq:XP_023983689.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023983689.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR RefSeq; XP_023983689.1; XM_024127921.3.
DR STRING; 9755.ENSPCTP00005011266; -.
DR KEGG; pcad:102986914; -.
DR InParanoid; A0A2Y9T6C7; -.
DR OrthoDB; 5482374at2759; -.
DR Proteomes; UP000248484; Chromosome 14.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR CDD; cd00167; SANT; 2.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF5; NUCLEAR RECEPTOR COREPRESSOR 1; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Receptor {ECO:0000313|RefSeq:XP_023983689.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 435..486
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 620..674
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT DOMAIN 620..670
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 623..674
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1391..1433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1450..1570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1703..1771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1892..1930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1951..1974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2022..2049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2075..2163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2290..2393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2423..2445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..570
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..620
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..698
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..731
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..871
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1053..1084
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1151..1186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1391..1414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1496..1544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1703..1717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1722..1741
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1915..1930
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2027..2044
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2088..2122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2458 AA; 269296 MW; C5E82F17EF016F84 CRC64;
MSSSGYPPNQ GAFSTEQSRY PPHSVQYTFP STRHQQEFAV PDYRSSHLEV SQASQLLQQQ
QQQQLRRRPS LLSEFHPGSD RPQERRTGYE QFHPGPSPVD HDSLESKRPR LEQVSDSHFQ
RVSAAVLPLV HTLPEGVRSS ADAKKDPAFG VKHEAPSSPI SGQPCGDDQN ASPSKLSKEE
LIQSMDRVDR EIAKVEQQIL KLKKKQQQLE EEAAKPPEPE KPVSPPPVEQ KHRSIVQIIY
DENRKKAEEA HKIFEGLGPK VELPLYNQPS DTKVYHENIK TNQVMRKKLI LFFKRRNHAR
KQREQKICQR YDQLMEAWEK KVDRIENNPR RKAKESKTRE YYEKQFPEIR KQREQQERFQ
RVGQRGAGLS ATIARSEHEI SEIIDGLSEQ ENNEKQMRQL SVIPPMMFDA EQRRVKFINM
NGLMEDPMKV YKDRQFMNVW TDHEKEIFKD KFIQHPKNFG LIASYLERKS VPDCVLYYYL
TKKNENYKAL VRRNYGKRRG RNQQIARPSQ EEKVEEKEED KAEKTEKKEE EKKDEEEKDE
KEDSKENTKE KDKTESTAEE TEEREQATPR GRKTANSQGR RKGRVTRSMT SEAAAASAAA
AAATEEPPPP LPPPPEPIST EPVETSRWTE EEMEVAKKGL VEHGRNWAAI AKMVGTKSEA
QCKNFYFNYK RRHNLDNLLQ QHKQKASRKP REERDVSQCE SVASTVSAQE DEDIEASNEE
ENPEDSEGAE NSSDTESAPS PSPVEAVKPG EDSTENAPPR GTTEPAAELE ATPDTVPRPS
PSPAVPSTKA AEDDSVETQA NDSMAVDTAE PMDVEHEECG AEGISALGLP SAAKPDAVDV
EMAESSPSRV EGDPEDRDLE RSSEKPEPGD DDLGVAQQMS APRPELPSDH DSSATCSADE
DVDGEPERQR MFPMDSKPSL LNPTGSILVS SPIKPNPLDL PQLQHRAAVI PPMVSCTPCN
IPIGTPVSGF ALYQRHIKAM HESALLEEQR QRQEQTDLER RGAVSPRGAP KSPNREREVL
QPAPHQVITN LPEGVRLPTT RPTRPPPPLI PSSKTTVASE KPSFILGGSI SQGTPGTYLP
SPNQASYAPE AAKPSAGSIS LGLPRQQEAA KPATVPYIKQ EEFSPRSQNS QPEGLLVRAQ
HEGVVRGTTG AIQEGSITRG TPSSKLSVES IPSLRGSITQ GTPALSQAGI PTEALVKGPI
SRLSIEEGSP EKGREEAASK GHVIYEGKSG HILSYDNIKN AREGTRSPRT AHEISLKRSY
ESVEGALKQG LSMRESPVSA PLEGLICRAL PRGSPHSDLK ERTVLSGSIM QGTPRATTES
FEDGLKYPKQ IKRESPPIRA FEGAITKGKP YDGITTIKEM GRSIHEIPRQ DVLTQESQKT
PEVVQSTRPM VEGSISQGTP VKSDSSSGQS AIKHNVKSLV AGPSRLPRGL PPLEIRPESI
KAVERGKYED VKAGEPVRSR HTSVVSSGPS VLRSTLHEAP KAQLSPGIYE DTSARRTPGS
YASTASRGSP MMSRAPDVTI SSSKSTSHER KSTLTPTQRE SITAKSPVPG VDPAVSHSPF
EPHHRAGAPG EVYRSHLPTH LDPAMPFHRA LDPAAAAYLF QRQLSPTPGY PSQYQLYAME
NTRQTILNDY ITSQQMQVGL RPDVARGLSP REQQLGLPYP ATRGIIDLTN MPPAILVPHP
GGTSTPPMDR ITYIPGTQVT FPPRPYNSAS MSPGHSTHLA AAANAERERE REKERERLAA
ASSDLYLRPG SEQPGRPSSH GYVRSPSPSV RAQETLLQQR PSVFQGTNGT SVITPLDPSA
QLRIMPLPAG GPSISQGLPA SRYNTAADAL AALVDAAASA PQMDVSKTKE SKHEAARLEE
NLRSRSAAVS EQQLEQKSLE AEKRAGQCLY TSSALPSGKP QPHSAVVYSE AGKEKGPPPK
SRYEEELRTR GKTTITAANF IDVIITRQIA SDKDARERGS QSSDSSGSLS SHRYETPGDA
IEVISPASSP APPPERLQAY QPEVVKASQA ENEACRQYEG PLHHYRPQPE SPSPQPPPPP
SSQAEGVGQV PRTHRLITLA DHICQIITQD FARNQVPSQP PQQPPTSTFQ NSPSALVSTP
VRTKTSNRYS PESQSQSLHH QRPGARVSPE NLVDKSRGSI RPGKSPERSH VSSEPYEPIS
PPQVPVVHEK QDSVLLLAQR GAEPAEQRND SRSPGSISYL PSFFTKLENT SPMVKSKKQE
IFRKLNSSGG GDSDMAAAQP GTEIFNLPAV TTSGSVSSRG HSFADPASNL GLEDIIRKAL
MGSFEDKVED HGVTMPQPLG GVPGGAGTSV VTSGEARREE GDPSPHSGGV CKPKLISKSN
SRKSKSPIPG QGYLGAERPS SASSVHSEGD YHRQTPGWAW EDRPSSTGST QFPYNPLTMR
MLSSTPPAPV ACAPVACAPV ACAPASASPA APHQPSRIWD REPAPLLSAQ YETLSDSD
//
