ID A0A2Y9T815_PHYMC Unreviewed; 1191 AA.
AC A0A2Y9T815;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Rho GTPase-activating protein 20 isoform X1 {ECO:0000313|RefSeq:XP_023987066.1};
GN Name=ARHGAP20 {ECO:0000313|RefSeq:XP_023987066.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023987066.1};
RN [1] {ECO:0000313|RefSeq:XP_023987066.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023987066.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_023987066.1; XM_024131298.3.
DR AlphaFoldDB; A0A2Y9T815; -.
DR InParanoid; A0A2Y9T815; -.
DR OrthoDB; 2964977at2759; -.
DR Proteomes; UP000248484; Chromosome 16.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13319; PH_RARhoGAP; 1.
DR CDD; cd17115; RA_RHG20; 1.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR047887; ARHGAP20_PH.
DR InterPro; IPR047888; ARHGAP20_RA.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23179:SF28; RHO GTPASE-ACTIVATING PROTEIN 20; 1.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 194..283
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 365..551
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 981..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1050..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1053..1067
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1152..1170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1191 AA; 132562 MW; 39CAE2B760278295 CRC64;
MEAMSPQQET LGGQPGRSSS LTGVSRIAGA PGTKKKMKTL AERRRSAPSL ILDKALQKRP
STKESPSASV DTCAFLSSFL CSNRTLLIDG RVELKRGLQR QERHLFLFND LFIVAKIKYN
NNFKIKNKIK LSDMWTASCV DEVGEGNTNA LKSFVLGWPT VNFVATFSSP EQKDKWLSLL
QRYINLEKEK DYPKSIPLKI FAKDIGNCAY SKTITVTNSD TANEVINMSL PMLGITGSER
EYQLWVNSGK EEAPYPLIGH EYPYGIKMSH LRDTALLTQG SKDSPTPSNF QEPFLMEQLP
REMQCQFILK PSRLAVAQQL SDSGQKTFKR RRSIINWAFW RGSSTHLDNL PTSPTSPVPG
QLFGVSLPNI CENDNLPKAV LDMLFFLNQK GPLTKGIFRQ SANVKSCREL KEKLNSGAEV
QLDCESIFVI ASVLKDFLRN IPGSTFSSDL YDHWVCVMDQ GNDEEKINAV QRLLDQLPRA
NVILLRYLFG VLYNIEQHSS SNQMTAFNLA VCIAPSILWP PTSSSPELEN EFTKKVSLLI
QFLIENCCRI FGEEITSLLG EVSVRCDTRE NASADISCFQ LNDSSYDSLE NELNEDVDAP
CSDLVKKLGQ GSRSMDSVLT LSDYDLDQPE VEGLLTLSDF DLDHSKDEDI QMEQPLESKP
VNIAVYTKDP LQDHARAPSG MSTPSHLSTT AADAPKSLRR HRRCSEPSYD YLDSKLSYLR
EFYQKKLRKS SCDAILSKKD ERHLNQNQPL QEEGKTCYKK SLVIGTDIKK NATNKNVKKK
SLSDNEGNHV KLFPKSKPVA ISMASYSHMS SCEHPRNQTF DTDTSGYSPP HTTDAFKSSR
RHRRCSEPNI DDQHCKLTYL RGIHSKKQHK ASYEASLLHG EEDYLKRHKS LQMEGQKLIN
QSLVMGIEVG KTSATNQNTD KVLPPRLNIC SRTSYSSLSS PGTSPSGSSV SSQDSAFSQI
SEHSVFTPTE TSSPIDCTFQ AQRKQEELSS DFSSSSLISG IPGPSSGQAS GRLAYTKKDS
VEWHSQMHSV TLHPSTWLRN GVASLKNWSL KKKARAPRPE ENKIGSLKGH TEPPPHASGV
PEANALHERQ KDMPRRAAEG LGAVQTARWY SSYPSQDSEK HCSSPVSLVE DRLGLCMKSP
EEGEISGQCS PGTLPHGRSS PSSLTVDHVC SPDSGPTVVC DVEDRHLTKD I
//
