ID A0A2Y9T823_PHYMC Unreviewed; 1938 AA.
AC A0A2Y9T823;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Probable helicase with zinc finger domain isoform X2 {ECO:0000313|RefSeq:XP_023985792.1};
GN Name=HELZ {ECO:0000313|RefSeq:XP_023985792.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023985792.1};
RN [1] {ECO:0000313|RefSeq:XP_023985792.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023985792.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_023985792.1; XM_024130024.3.
DR Proteomes; UP000248484; Chromosome 14.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd18077; DEXXQc_HELZ; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.1000.10; Zinc finger, CCCH-type; 1.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR049569; HELZ_DEAD-box_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF365; HELICASE WITH ZINC FINGER DOMAIN-RELATED; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF90229; CCCH zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|RefSeq:XP_023985792.1};
KW Helicase {ECO:0000313|RefSeq:XP_023985792.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Nucleotide-binding {ECO:0000313|RefSeq:XP_023985792.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 178..206
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 178..206
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 1247..1461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1520..1572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1579..1598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1608..1643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1703..1722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1730..1848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1871..1938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1358..1372
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1373..1388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1389..1408
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1409..1434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1557..1572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1619..1638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1755..1822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1871..1888
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1913..1938
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1938 AA; 217593 MW; 6F2445DB871744FD CRC64;
MEDRRAEKSC EQACESLKRQ DYEMTLKHCT EALLSLGQYS MADFTGPCPL EIESIKIESL
LYRIASFLQL KNYGQADEDC RHVLGEGLAK GDGTFQAVLC CMQLKGKLQP VSSILARSLT
GESLNGMVTK DLTRLKILLT ETETATGNVL SGYHVEDLEE GSCNGWHFRP PPRGITSSEE
YTLCKRFLEQ GICRYGAQCT SAHSQEELAE WQKRYASRLI KLKQQNENKQ LSGSYMETLI
EKWMNSLSPE KVLSECIEGV KVEHNPDLSV TVNTKKSHQT WTFALTCKPA RMLYRVALLY
DAHRPHFSII AISAGDSATQ VSQEVPENCQ EWIGGKMAQN GLDHYVYKVG IAFNTEIFGT
FRQTIVFDFG LEPVLMQRVM IDAASTEDLE YLMHAKQQLV TTAKRWDSSS KTIIDFEPNE
TTDLEKSLLI RYQIPLSADQ LFTQSVLDKS LTKTNYQSRL HDLLYIEEIA QYKEVSKFNL
KVQLQILASF MLTGVSGGAK YAQNGQLFGR FKLSETLSED TLAGRLVMTK VNAVYLLPVP
KEKLVQTQGT KEKVYEATIE EKTKEYIFLR ISRECCEELH LRPDYDTQVE LQFQLNRLPL
CEMHYALDRI KDNGVLFPDI TMTPTIPWSP NRQWDEQLDP RLNAKQKEAV LAVTTPLSVQ
LPPVLIIGPY GTGKTFTLAQ AVKHILQQQE TRILICTHSN SAADLYIKDY LHPYVEAGNP
QARPLRVYFR NRWVKTVHPV VHQYCLISSA HSTFQMPQKE DILKHRVVVV TLNTSQYLCQ
LDLEPGFFTH VLLDEAAQAM ECETIMPLAL ATKDTRVVLA GDHMQLSPFV YSEFARERNL
HVSLLDRLYE HYPAEFPCRI LLCENYRSHE AIINYTSELF YEGKLMASGK QPAHKDFYPL
TFFTARGEDV QEKNSTAFYN NAEVFEVVER VEELRRKWPV AWGKLDDGSI GVVTPYADQV
FRIRAELRKK RLSDVNVERV LNVQGKQFRV LFLSTVRTRH TCKHKQTPIK KKEQLLEDST
EDLDYGFLSN YKLLNTAITR AQSLVAVVGD PIALCSIGRC RKFWERFIAL CHENNSLHGI
TFEQIKAQLE ALELKKTYVL NPLAPEFIPR ALRVQHTGNT NRLQQSPPKG KSLHHIQNDH
FQNDGIVQPN PSVLIGNPIR AYTPPPPLGP HPNLGKSPSP VQRIDPHTGT SILYVPAVYG
GNVVMSVPLP VPWTGYQGRF AVDPRIITHQ AAMAYNMNLL QTHGRGSPIP YGLGHHPPVS
IGQTQNQHPE KDQHEQSRNG KSDTNNPGPE INKIRTPEKK PTESKQMDLE SNPQNRSPES
RPGVVYPKFH RKDNPNPRHV TLPLPAPHAQ CAVPGRHFHP LPPLPRPPFP IPQQHASSNQ
QQNNLPEQPN QMPPHPNQGA PRQSPLGQPP PQLSAACQAG PSSAFFNNAV SHRPQSPPAE
AAIPEQQPPP MLQGGHSPLR AIAQPGPILP SHLNNFTDEN PPGLPVGEAL DRVHGSVALE
ALRQQQVRLQ QWSEHHACLS QGSAPYPHHH HPHPHLQHLP QPPIGYHQPP VRADWKLPGS
AEDEAETTDS RLQDLIRELS NRDQSETREL AEMPPPQSRL LQYRQIQTRS PPAVPSPPSS
ADHSTHFSTF SDSSRDLEVA SNPAFPPRLP PQLFSSPFSL PSEHLAPPPL KCLAPDGAWT
FANLQQNRLM GPGFPYGLPP LPPRPPQTPF VHMQSHQPAV SQEPFHPLSA RTVSSSSLPS
LEEYEPRGPG RPLYQRRISS SSVQPCPEEV STPQDSLAQC KELQDHNNQS SFNFSSPESW
VNTTSSTPYQ NIPCNGSSRT AQPRELIAPP KTVKPPEDHL KPENLEGSSS FNYSVLQHLG
QFPPLMPNKQ IAESAHSSSQ QSCGGSRPAM SYASALRAPP KPRPPPEQAK KSSDPLSLFQ
ELSLGSSSGS NGFYSYFK
//
