ID A0A2Y9T911_PHYMC Unreviewed; 224 AA.
AC A0A2Y9T911;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=MIF4G domain-containing protein isoform X1 {ECO:0000313|RefSeq:XP_023986162.1, ECO:0000313|RefSeq:XP_028340173.1};
GN Name=MIF4GD {ECO:0000313|RefSeq:XP_023986162.1,
GN ECO:0000313|RefSeq:XP_028340173.1, ECO:0000313|RefSeq:XP_028340174.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023986162.1};
RN [1] {ECO:0000313|RefSeq:XP_023986162.1, ECO:0000313|RefSeq:XP_028340173.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023986162.1,
RC ECO:0000313|RefSeq:XP_028340173.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions in replication-dependent translation of histone
CC mRNAs which differ from other eukaryotic mRNAs in that they do not end
CC with a poly-A tail but a stem-loop. May participate in circularizing
CC those mRNAs specifically enhancing their translation.
CC {ECO:0000256|ARBA:ARBA00037643}.
CC -!- SUBUNIT: Interacts with eif4g1, eif4g2 and slbp; probably tethered by
CC SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also
CC interacts with eif4g1 which is bound to their 5'-end.
CC {ECO:0000256|ARBA:ARBA00038641}.
CC -!- SIMILARITY: Belongs to the MIF4GD family.
CC {ECO:0000256|ARBA:ARBA00038204}.
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DR RefSeq; XP_023986162.1; XM_024130394.1.
DR RefSeq; XP_028340173.1; XM_028484372.2.
DR RefSeq; XP_028340174.1; XM_028484373.2.
DR STRING; 9755.ENSPCTP00005007708; -.
DR KEGG; pcad:102980299; -.
DR OrthoDB; 4208729at2759; -.
DR Proteomes; UP000248484; Unplaced.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR Gene3D; 1.25.40.180; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR PANTHER; PTHR23254; EIF4G DOMAIN PROTEIN; 1.
DR PANTHER; PTHR23254:SF17; MIF4G DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02854; MIF4G; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 1..207
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
SQ SEQUENCE 224 AA; 25739 MW; 78FB173CBEBE5183 CRC64;
MVMGEPRREE YKIQSFDAAT QQLLKTALKD PGAVDLEKVA NVIVDHSLQD CVFSKEAGRM
CYAIIQAESK QAGQSVFRRG LLNRLQQEYQ AREQLRARSL RGWVCYVTFI CNIFDYLRVN
NMPMMALVNP VYDCLFRLAQ PDSLSKEEEV DCLVLQLHRV GEQLEKMNGQ RMDELFVLIR
DGFLLPTCLS SLAQLLLLEI IEFRAAGWKT TPAAHKYYYS EVSD
//
