ID A0A2Y9TAA8_PHYMC Unreviewed; 1939 AA.
AC A0A2Y9TAA8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Probable helicase with zinc finger domain isoform X1 {ECO:0000313|RefSeq:XP_023985789.1, ECO:0000313|RefSeq:XP_023985790.1};
GN Name=HELZ {ECO:0000313|RefSeq:XP_023985789.1,
GN ECO:0000313|RefSeq:XP_023985790.1, ECO:0000313|RefSeq:XP_023985791.1,
GN ECO:0000313|RefSeq:XP_028355635.1, ECO:0000313|RefSeq:XP_028355636.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023985790.1};
RN [1] {ECO:0000313|RefSeq:XP_023985789.1, ECO:0000313|RefSeq:XP_023985790.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023985789.1,
RC ECO:0000313|RefSeq:XP_023985790.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_023985789.1; XM_024130021.3.
DR RefSeq; XP_023985790.1; XM_024130022.3.
DR RefSeq; XP_023985791.1; XM_024130023.3.
DR RefSeq; XP_028355635.1; XM_028499834.2.
DR RefSeq; XP_028355636.1; XM_028499835.2.
DR STRING; 9755.ENSPCTP00005014376; -.
DR Ensembl; ENSPCTT00005015904; ENSPCTP00005014376; ENSPCTG00005010269.
DR KEGG; pcad:102979716; -.
DR OrthoDB; 5405202at2759; -.
DR Proteomes; UP000248484; Chromosome 14.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd18077; DEXXQc_HELZ; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.1000.10; Zinc finger, CCCH-type; 1.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR049569; HELZ_DEAD-box_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF365; HELICASE WITH ZINC FINGER DOMAIN-RELATED; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF90229; CCCH zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|RefSeq:XP_023985789.1,
KW ECO:0000313|RefSeq:XP_023985790.1};
KW Helicase {ECO:0000313|RefSeq:XP_023985789.1,
KW ECO:0000313|RefSeq:XP_023985790.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723};
KW Nucleotide-binding {ECO:0000313|RefSeq:XP_023985789.1,
KW ECO:0000313|RefSeq:XP_023985790.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 178..206
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 178..206
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 1248..1466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1521..1573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1580..1599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1609..1646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1704..1723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1731..1849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1872..1939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1359..1373
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1374..1389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1390..1409
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1410..1435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1558..1573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1620..1639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1756..1823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1872..1889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1914..1939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1939 AA; 217680 MW; 6C5659BD874C6F4C CRC64;
MEDRRAEKSC EQACESLKRQ DYEMTLKHCT EALLSLGQYS MADFTGPCPL EIESIKIESL
LYRIASFLQL KNYGQADEDC RHVLGEGLAK GDGTFQAVLC CMQLKGKLQP VSSILARSLT
GESLNGMVTK DLTRLKILLT ETETATGNVL SGYHVEDLEE GSCNGWHFRP PPRGITSSEE
YTLCKRFLEQ GICRYGAQCT SAHSQEELAE WQKRYASRLI KLKQQNENKQ LSGSYMETLI
EKWMNSLSPE KVLSECIEGV KVEHNPDLSV TVNTKKSHQT WTFALTCKPA RMLYRVALLY
DAHRPHFSII AISAGDSATQ VSQEVPENCQ EWIGGKMAQN GLDHYVYKVG IAFNTEIFGT
FRQTIVFDFG LEPVLMQRVM IDAASTEDLE YLMHAKQQLV TTAKRWDSSS KTIIDFEPNE
TTDLEKSLLI RYQIPLSADQ LFTQSVLDKS LTKTNYQSRL HDLLYIEEIA QYKEVSKFNL
KVQLQILASF MLTGVSGGAK YAQNGQLFGR FKLSETLSED TLAGRLVMTK VNAVYLLPVP
KEKLVQTQGT KEKVYEATIE EKTKEYIFLR ISRECCEELH LRPDYDTQVE LQFQLNRLPL
CEMHYALDRI KDNGVLFPDI TMTPTIPWSP NRQWDEQLDP RLNAKQKEAV LAVTTPLSVQ
LPPVLIIGPY GTGKTFTLAQ AVKHILQQQE TSRILICTHS NSAADLYIKD YLHPYVEAGN
PQARPLRVYF RNRWVKTVHP VVHQYCLISS AHSTFQMPQK EDILKHRVVV VTLNTSQYLC
QLDLEPGFFT HVLLDEAAQA MECETIMPLA LATKDTRVVL AGDHMQLSPF VYSEFARERN
LHVSLLDRLY EHYPAEFPCR ILLCENYRSH EAIINYTSEL FYEGKLMASG KQPAHKDFYP
LTFFTARGED VQEKNSTAFY NNAEVFEVVE RVEELRRKWP VAWGKLDDGS IGVVTPYADQ
VFRIRAELRK KRLSDVNVER VLNVQGKQFR VLFLSTVRTR HTCKHKQTPI KKKEQLLEDS
TEDLDYGFLS NYKLLNTAIT RAQSLVAVVG DPIALCSIGR CRKFWERFIA LCHENNSLHG
ITFEQIKAQL EALELKKTYV LNPLAPEFIP RALRVQHTGN TNRLQQSPPK GKSLHHIQND
HFQNDGIVQP NPSVLIGNPI RAYTPPPPLG PHPNLGKSPS PVQRIDPHTG TSILYVPAVY
GGNVVMSVPL PVPWTGYQGR FAVDPRIITH QAAMAYNMNL LQTHGRGSPI PYGLGHHPPV
SIGQTQNQHP EKDQHEQSRN GKSDTNNPGP EINKIRTPEK KPTESKQMDL ESNPQNRSPE
SRPGVVYPKF HRKDNPNPRH VTLPLPAPHA QCAVPGRHFH PLPPLPRPPF PIPQQHASSN
QQQNNLPEQP NQMPPHPNQG APRQSPLGQP PPQLSAACQA GPSSAFFNNA VSHRPQSPPA
EAAIPEQQPP PMLQGGHSPL RAIAQPGPIL PSHLNNFTDE NPPGLPVGEA LDRVHGSVAL
EALRQQQVRL QQWSEHHACL SQGSAPYPHH HHPHPHLQHL PQPPIGYHQP PVRADWKLPG
SAEDEAETTD SRLQDLIREL SNRDQSETRE LAEMPPPQSR LLQYRQIQTR SPPAVPSPPS
SADHSTHFST FSDSSRDLEV ASNPAFPPRL PPQLFSSPFS LPSEHLAPPP LKCLAPDGAW
TFANLQQNRL MGPGFPYGLP PLPPRPPQTP FVHMQSHQPA VSQEPFHPLS ARTVSSSSLP
SLEEYEPRGP GRPLYQRRIS SSSVQPCPEE VSTPQDSLAQ CKELQDHNNQ SSFNFSSPES
WVNTTSSTPY QNIPCNGSSR TAQPRELIAP PKTVKPPEDH LKPENLEGSS SFNYSVLQHL
GQFPPLMPNK QIAESAHSSS QQSCGGSRPA MSYASALRAP PKPRPPPEQA KKSSDPLSLF
QELSLGSSSG SNGFYSYFK
//
