ID A0A2Y9TBU6_PHYMC Unreviewed; 1356 AA.
AC A0A2Y9TBU6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Partitioning defective 3 homolog isoform X2 {ECO:0000313|RefSeq:XP_023985514.1};
GN Name=PARD3 {ECO:0000313|RefSeq:XP_023985514.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023985514.1};
RN [1] {ECO:0000313|RefSeq:XP_023985514.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023985514.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
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DR RefSeq; XP_023985514.1; XM_024129746.2.
DR STRING; 9755.ENSPCTP00005003749; -.
DR Ensembl; ENSPCTT00005004141; ENSPCTP00005003749; ENSPCTG00005002619.
DR Proteomes; UP000248484; Chromosome 11.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0120157; C:PAR polarity complex; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IEA:Ensembl.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF10; PARTITIONING DEFECTIVE 3 HOMOLOG; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 3.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 271..347
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 460..545
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 589..664
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 80..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 926..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1106..1356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..977
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..1074
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1178..1198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1214..1245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1356 AA; 151237 MW; 4A0BD9955FCC4E37 CRC64;
MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD
LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEMFGSELGT NSVSAFQPYQ
ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL
KQNTAGSPAA CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVD KWLEKQEQDE
DGTEEDSSRV EPVGHADTGV ENVPNFSLDD MVKLVQVPND GGPLGIHVVP FSARGGRTLG
LLVKRLEKGG KAEQENLFHE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT SIIWFHVVPA
ANKEQYEQLS QSERNNYYPS RFSPDSQHVD HRSVNSAGPQ ALPRVPRPNA LPEHADPHPR
LLPQSAQPSG KPPAAPGPAV HHVFSPSSGY NTKKVGKKLN IQLKKGTEGL GFSITSRDVT
IGGSAPIYVK NILPRGAAIQ DGRLKAGDRL IEVNGVDLAG KSQEEVVSLL RSTKMEGTVS
LLVFRQEDAF HPRELNAEPS QMQIPKETKA EDEDTVLTPD GTREFLTFEV PLNDSGSAGL
GVSVKGNRSK ENHADLGIFV KSIINGGAAS KDGRLRVNDQ LIAVNGESLL GKTNQDAMET
LRRSMSTEGN KRGMIQLIVA RRVTKGTELK SPGSPSGPEL PIETVLDDRE RRISHSLYSG
LEGLDESPTR NAALSRIMGE SGKYQLSPTV NMPQDDTVII EDDRLPVLPP HLSDQSSSSS
HDDVGFVTTD TGAWAKAGIS ESAECSLSPD VDPVLAFQRE GFGRQSMSEK RTKQFSDASQ
LDFVKTRKSK SMDLGIADET KLNTVDDQKA GSPSRDVGPS LGLKKSSSLE SLQTAVAEVT
LNGDIPFHRP RPRIIRGRGC NESFRAAIDK SYDKPAADDD DEGMETLEED TEESSRSGRE
SVSTASDQPS HSLERQMNGN QERGEKTDRR KEKMGKEKKK DRDKEKEKMK AKKGKLRGLG
DMFRFGKHRK DDKIEKTGKI KMQDSLTSEE ERVRMKQEQE RIQAKTREFR ERQARERDYA
EIQDFHRTFG CDDELMYGGI SSYEGSMALS TRPQSPREGH MMDALYAQVK KPRNSKPLPA
DSNRSTPSNH DRIQRLRQEF QQAKQDEDVE DRRRTYSFEQ PWPNSRPSAQ SGRHSVSVEV
QMQRRRQEER ESFQQAQRQY SSLPRQSRKN GSSVSQDSWE QNYAAGEGFQ SAKENPRYSS
YQGSRNGYLG GHGLNARVML ETQELLRQEQ RRKEQQMKKP PPPPEGLNNY DSYKQVQDPS
HIPPKGPFRQ DVPPSPSQVA RLNRLQTPEK GRPFYS
//
