ID   A0A2Y9TCF5_PHYMC        Unreviewed;       740 AA.
AC   A0A2Y9TCF5;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=F-BAR and double SH3 domains protein 2 isoform X5 {ECO:0000313|RefSeq:XP_023987382.1};
GN   Name=FCHSD2 {ECO:0000313|RefSeq:XP_023987382.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023987382.1};
RN   [1] {ECO:0000313|RefSeq:XP_023987382.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_023987382.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_023987382.1; XM_024131614.3.
DR   AlphaFoldDB; A0A2Y9TCF5; -.
DR   STRING; 9755.ENSPCTP00005027109; -.
DR   Ensembl; ENSPCTT00005029901; ENSPCTP00005027154; ENSPCTG00005019385.
DR   KEGG; pcad:102984480; -.
DR   InParanoid; A0A2Y9TCF5; -.
DR   OrthoDB; 3674259at2759; -.
DR   Proteomes; UP000248484; Chromosome 16.
DR   CDD; cd07677; F-BAR_FCHSD2; 1.
DR   CDD; cd11894; SH3_FCHSD2_2; 1.
DR   CDD; cd11761; SH3_FCHSD_1; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 2.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR034934; FCHSD2_F-BAR_dom.
DR   InterPro; IPR035556; FCHSD2_SH3_2.
DR   InterPro; IPR035460; FCHSD_SH3_1.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR15735:SF11; F-BAR AND DOUBLE SH3 DOMAINS PROTEIN 2; 1.
DR   PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00055; FCH; 1.
DR   SMART; SM00326; SH3; 2.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 2.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS50002; SH3; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          8..282
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          469..530
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          567..629
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          303..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          633..740
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          357..391
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        648..669
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        670..705
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  84312 MW;  AC40655F39DB756B CRC64;
     MQPPPRKVKV TQELKNIQVE QMTKLQAKHQ AECDLLEDMR TFSQKKAAIE REYAQGIQKL
     ASQYLKRDWP GIKADDRNDY RSMYPVWKSF LEGTMQVAQS RINICENYKN FISEPARTVK
     SLKEQQLKRC VDQLTKIQTE LQETVKDLAK GKKKYFETEQ MAHAVREKAD IEAKSKLSLF
     QSRISLQKAS VKLKARRSEC NSKATHARND YLLTLAAANA HQDRYYQTDL VNIMKALDGN
     VYDHLKDYLI AFSRMELETC QAVQNTFQFL LETSSKVVRD YNLQLFLQEN AVFHKPQPFQ
     FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLD DLECHGVAVS
     EQGRTELEQK IDEARENIRK AEIIKLKAEA RLDLLKQIGV SVDTWLKSAM NQVMEELENE
     RWARLPAVTN NGTLHSLNAD TEREEGEEFE DNMDVFDDSS SSPSGTLRNY PLTCKVVYSY
     KASQPDELTI EEHEVLEVIE DGDMEDWVKA RNKVGQVGYV PEKYLQFPTS NSLLSMLQSL
     AALDSRSHTS SNSTEAELVS GSLNGDASVC FVKALYDYEG QTDDELSFPE GAIIRILNKE
     NQDDDGFWEG EFNGRIGVFP SVLVEELSAS ENGDTPWMRE IQISPSPKLP GSLPPLPLYD
     QPPSSPYPSP DKRSSQYFPR SPSANENSFH AESPGFSQAS RHTPETSYGK LRPVRAAPPP
     PTQNHRRPAE KIEDVEITLV
//