ID   A0A2Y9TD79_PHYMC        Unreviewed;       679 AA.
AC   A0A2Y9TD79;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=B-related factor 1 {ECO:0000256|ARBA:ARBA00031009};
GN   Name=BRF1 {ECO:0000313|RefSeq:XP_023986765.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023986765.1};
RN   [1] {ECO:0000313|RefSeq:XP_023986765.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_023986765.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the TFIIB family.
CC       {ECO:0000256|ARBA:ARBA00010857}.
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DR   RefSeq; XP_023986765.1; XM_024130997.3.
DR   AlphaFoldDB; A0A2Y9TD79; -.
DR   STRING; 9755.ENSPCTP00005011034; -.
DR   Ensembl; ENSPCTT00005012201; ENSPCTP00005011034; ENSPCTG00005007623.
DR   Proteomes; UP000248484; Chromosome 11.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd20553; CYCLIN_TFIIIB90_rpt1; 1.
DR   CDD; cd20554; CYCLIN_TFIIIB90_rpt2; 1.
DR   Gene3D; 2.20.25.10; -; 1.
DR   Gene3D; 1.10.472.10; Cyclin-like; 2.
DR   Gene3D; 1.20.5.650; Single helix bin; 1.
DR   InterPro; IPR011665; BRF1_TBP-bd_dom.
DR   InterPro; IPR013763; Cyclin-like_dom.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618:SF4; TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT; 1.
DR   PANTHER; PTHR11618; TRANSCRIPTION INITIATION FACTOR IIB-RELATED; 1.
DR   Pfam; PF07741; BRF1; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; Cyclin-like; 2.
DR   SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR   PROSITE; PS51134; ZF_TFIIB; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00469};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00469};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00469}.
FT   DOMAIN          2..33
FT                   /note="TFIIB-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51134"
FT   REGION          343..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          546..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          307..334
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        551..571
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        641..655
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   679 AA;  73880 MW;  311368A084B00925 CRC64;
     MTGRVCRGCG GTDIELDAAR GDAVCTGCGS VLEDNIIVSE VQFVENSGGG SSAVGQFVSL
     DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RQIHHLGNQL QLNQHCLDTA FNFFKMAVSK
     HLTRGRKMAH VIAACLYLVC RTEGTPHMLL DLSDLLQVNV YVLGKTFLLL ARELCINAPA
     IDPCLYIPRF AHLLEFGDKN HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH
     DFRRTVKEVI SVVKVCESTL RKRLTEFEDT PTSQLTVDEF MKVDLEEECD PPSYTAGQRK
     LRMKQLEQVL SKQLEEVEGE ISSYQDAIEI ELENSRPKAK GALASLTKDG SVEDTTSSLF
     GEEDAEDEEL EAAASHLNKD FYQELLGGGL PGSAEAAGGP EGGGGPPALE SLLGPLPTAA
     SLGISDSIRE CISSQSRDPK DASGDGELDL SGIDDLEIDR YILNEAEARV KAELWMRENA
     EYLREQREKE ARIAKERELG IYKEHKPKKS CKRREPIQAS TAGEAIEKML EQKKISSKIN
     YSVLRGLDSK GGAGPRREHA RPQETAGARR LSRRKAPAST SGADPVAGVR KRLRPMVSTQ
     PAKKVAVGEA LLPSPPSLEA EPVRPTSAVV VESGPVSYHP EEDADEEDPD EEDGEPCVSA
     LQMMGGNDYG CDGDDDDGY
//