ID A0A2Y9TDW6_PHYMC Unreviewed; 954 AA.
AC A0A2Y9TDW6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=von Willebrand factor C and EGF domain-containing protein {ECO:0000313|RefSeq:XP_023989096.1};
GN Name=VWCE {ECO:0000313|RefSeq:XP_023989096.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023989096.1};
RN [1] {ECO:0000313|RefSeq:XP_023989096.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023989096.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_023989096.1; XM_024133328.3.
DR AlphaFoldDB; A0A2Y9TDW6; -.
DR STRING; 9755.ENSPCTP00005028073; -.
DR Ensembl; ENSPCTT00005030901; ENSPCTP00005028073; ENSPCTG00005019947.
DR KEGG; pcad:102996175; -.
DR InParanoid; A0A2Y9TDW6; -.
DR OrthoDB; 19806at2759; -.
DR Proteomes; UP000248484; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 6.20.200.20; -; 4.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333:SF1; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF00093; VWC; 3.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 2.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01208; VWFC_1; 4.
DR PROSITE; PS50184; VWFC_2; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..954
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016089277"
FT DOMAIN 142..180
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 181..219
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 220..262
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 384..441
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 499..560
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 566..626
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 627..685
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 685..743
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 292..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..873
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 954 AA; 99574 MW; 08B30C3AA88FF9C3 CRC64;
MWAGLLLRAA CVALLLPGTP ARGYTGRKTP GHFGAERRRL GPHVCLSGFG SGCCPGWAPS
MGSGHCTLPL CSFGCGTGIC IAPNVCSCQD GEQGPTCPEA HGPCGEYGCD LTCNHGGCQE
VARVCPVGFS MTETAVGIRC TDIDECLSSS CEGHCMNTEG GFVCECGPGM QLSADRHSCQ
DTDECLGTPC EQRCKNSIGS YRCSCRTGFH LHGNRHSCVD VNECRRPLER RVCHHSCHNT
VGSFLCTCRP GFRLRADRVS CEAFPKAVLA PSAILQPLQH PPKMLLLLPE AGRPALSPGH
SPPSGAPGPP AGVRTTRLPS PTPALPTSSA SALTQLLSAP MATPVPSPSP LGALRPPSRI
QEKVVVTPSL PRGPEATQLA PGPSACWHLG AMRESGSRWT EPGCSQCWCE DGEVTCEKVT
CEAACSHPIP SGDGGCCPLC TGCFHSGVIR AEGDVFSPPN QNCTVCVCLA GNVSCISPEC
PPGPCQASPK SDCCTCVPVR CYFRGRWYAD GAVFSGGDDE CTTCVCQNGE VECSFTPCPE
LACPREEWWL GPGQCCFTCR EPAPMTGCSL DDNGVEFPVG QIWSPGDPCE LCICQADGSV
SCKRTDCVDS CPHPIRIPGQ CCPDCSAGCT YTGRIFYNNQ TFPSVLDPCL SCICLLGSVA
CSPVDCPITC SYPFHPDGEC CPVCRDCNYE GRKVGNGQVF TLDDEPCTQC ICQMGEVSCE
KMPCQQACLD PSTPLRDCCS SCPDSLEESR GLSPHGDVEL SKVARTPRGD PEALLNCSSC
PGPPAVSPQR PALQLLQLLL RTNLSNMQTI AVSPSGAQAL PSPPLGPGGM FPGEPGASQP
PRPSPGPSIP PGASSLPPAS PGAPGPPPVT PEPSSSASGA HTASRQPSLP ATIRRRASAL
STMGPSPSEA PVTILRPRRL SPATSRLSAA LAATASPGPQ EPTMGPSQQE ESTV
//
