ID A0A2Y9TGJ3_PHYMC Unreviewed; 1766 AA.
AC A0A2Y9TGJ3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=NEDD4-binding protein 2 isoform X1 {ECO:0000313|RefSeq:XP_007129301.2, ECO:0000313|RefSeq:XP_028347835.1};
GN Name=N4BP2 {ECO:0000313|RefSeq:XP_007129301.2,
GN ECO:0000313|RefSeq:XP_028347835.1, ECO:0000313|RefSeq:XP_028347839.1,
GN ECO:0000313|RefSeq:XP_054942052.1, ECO:0000313|RefSeq:XP_054942053.1,
GN ECO:0000313|RefSeq:XP_054942054.1, ECO:0000313|RefSeq:XP_054942055.1,
GN ECO:0000313|RefSeq:XP_054942056.1, ECO:0000313|RefSeq:XP_054942057.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028347839.1};
RN [1] {ECO:0000313|RefSeq:XP_007129301.2, ECO:0000313|RefSeq:XP_028347835.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_007129301.2,
RC ECO:0000313|RefSeq:XP_028347835.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007129301.2; XM_007129239.4.
DR RefSeq; XP_028347835.1; XM_028492034.2.
DR RefSeq; XP_028347839.1; XM_028492038.2.
DR RefSeq; XP_054942052.1; XM_055086077.1.
DR RefSeq; XP_054942053.1; XM_055086078.1.
DR RefSeq; XP_054942054.1; XM_055086079.1.
DR RefSeq; XP_054942055.1; XM_055086080.1.
DR RefSeq; XP_054942056.1; XM_055086081.1.
DR RefSeq; XP_054942057.1; XM_055086082.1.
DR STRING; 9755.ENSPCTP00005021332; -.
DR Ensembl; ENSPCTT00005023500; ENSPCTP00005021332; ENSPCTG00005015217.
DR KEGG; pcad:102993318; -.
DR OrthoDB; 5489998at2759; -.
DR Proteomes; UP000248484; Chromosome 7.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR GO; GO:0046404; F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; IEA:Ensembl.
DR GO; GO:0004520; F:DNA endonuclease activity; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR CDD; cd14365; CUE_N4BP2; 1.
DR Gene3D; 3.30.1370.110; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003892; CUE.
DR InterPro; IPR013899; DUF1771.
DR InterPro; IPR041801; N4BP2_CUE.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002625; Smr_dom.
DR InterPro; IPR036063; Smr_dom_sf.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR46535; NEDD4-BINDING PROTEIN 2; 1.
DR PANTHER; PTHR46535:SF1; NEDD4-BINDING PROTEIN 2; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF08590; DUF1771; 1.
DR Pfam; PF01713; Smr; 1.
DR SMART; SM01162; DUF1771; 1.
DR SMART; SM00463; SMR; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF160443; SMR domain-like; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS51140; CUE; 1.
DR PROSITE; PS50828; SMR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 45..88
FT /note="CUE"
FT /evidence="ECO:0000259|PROSITE:PS51140"
FT DOMAIN 1687..1766
FT /note="Smr"
FT /evidence="ECO:0000259|PROSITE:PS50828"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1579..1598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..775
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1583..1598
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1766 AA; 198192 MW; 96482CE885206C8C CRC64;
MPRRRKNLGG NPFRKTTNSK EVVSSVASHE EPTTTLPSMC ETKVDQEELF TSISEMFSDL
DPDVVYLMLS ECDFKVENAM DCLLELSATD AKIEESPSKS FVASENQVDA VGSEIMEKCP
PEEESEDSKM DSFLDMQLTE DLDSLIQNAF EKLNSSPDDH AYSFLPLQDV NNFSNPSAFI
NSDSSSVTPI LSTQNMDLNS ENVESSAPIL SSNSLTSHSL SNESKSFTKD NTLALEDSLL
SSSLNVANDT MMDCSNQIQK ELLESVCVKT QFSQAPVDLD ANELQAPSNR TVQNLGLGLL
GTGGDQKSSV PDVFVPSEEF NFQSHKQTEL PPKGKDVNYC PVLTPLPLLL PPPPPPPLWN
PMIPAFDLFQ GNHGFVAPVV TTAAHWRPVN YTFPPPVISH TSPTKVWRNK EGTSAYQVQE
TPVSQVVRKK TSSYVGLVLV LLRGLPGSGK SFLARTLQED NPSGVILSTD DYFYINGQYQ
FDVKYLGEAH EWNQNRAKEA FEKKVSPIII DNTNLQAWEM KPYVALSQKH KYKVLFREPD
TWWKFKPKEL ARRNIHGISK EKITRMLEHY QRFVSVPIIM SSSVPEKMER IELCAYSCDR
STSTRDNEDI ASEKEENVLS SSLKHPELIE EKKHDVTKEN LLPENVTYLP NADLNNGKKE
ISGMNPNIQN AFIQEAPDIY FSDSESKERA ADKSEKEEPV EMAPEKECSK TNADSFVERI
SPSICYGGNN QEDCGLSNTV PLQNEKSSSS ETLEERAGVK KKAFGKQKSK STSEKFPRQE
LSFVGDWPVD KSIGQRTKRN RKTEKALSIQ SDKKYNCPQS HKVLDSSLSV SIDCIQPQGS
PHENVEDDSK SQCDDASESF NSCKYGTYKN TEKDSFNIVG DWPSSDSLAQ REHRSRMPKA
GLNEPNLEFG INNSMNDMSL YTAREGCWGT SPEELKTLGS STRGSSEMLP NEMTCENKTC
PSKKIHRQHT LSLTFTNSVP TAPGGVRPQT LAEFQEEKTK EVPGIEVGKC TQTEPQDFAL
LWKIEKNKIS VSDSLRVLTG RLDGFKPKAF NINTKLDVQE TIPYRVMYDK STYVEESELT
SADESENLNI LCKLFGSFSL EALKDLYERC NKDIIWATSL LLDSETKLCE DTEFENIKKS
YDEAQIGPFS LGLNLKEIIS QRGSLEESNS SVPEFSHGIG ISNTNVQSTC NLEKENLEQA
EITAITTEKR GLITGIFPNV DLKNNNEVLP NSQAELSGLY NVKQFFPGTL KATATKNVSE
MEKNPEVTEI GDSIHSSLNL SDILNSVSST SDLELHEEIY FTDSFDINKS ENLPKDYVKF
PNTEEFMNED EREVEKILMA GSALSAGVTE EDKTETLNPT PVMAKSLTID CLELALPPEL
AFQLNELFGP VGIDSGSLTV EDCVVHIDLN LAKVIHEKWK ESVMERQRQE EVSCGKLMQD
PSLVGRVGLD NPEQKSSQRM GKKLLKTLAA PEMLPLLDHW NTHTKKVSLR EIMSEEIALQ
EKHDLKREPL IIEKDCATKL KEKQLFKIFP AINQNFLVDI FKDHNYSLEH TVQFLNCVLE
GDPVKTVVAQ EFVHQNENVT SHTAQKSKEK KAKKLKETED IPSEPSFQDF EYPEYDDYRA
EAFLHQQKRM ECYSKAKEAY RLGKKNVATF YAQQGSLHEQ KMKEANHLAA VEIFEKVNAS
LLPQNVLDLH GLHVDEAIEH LMTVLQQKTE EFKQNGGKPY LSVITGRGNH SQGGVARIKP
AVIKYLTSHS FRFSEIKPGC LKVMLK
//
