ID   A0A2Y9TGW7_PHYMC        Unreviewed;       957 AA.
AC   A0A2Y9TGW7;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Regulating synaptic membrane exocytosis protein 1 isoform X12 {ECO:0000313|RefSeq:XP_023988787.1};
GN   Name=RIMS1 {ECO:0000313|RefSeq:XP_023988787.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023988787.1};
RN   [1] {ECO:0000313|RefSeq:XP_023988787.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_023988787.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_023988787.1; XM_024133019.3.
DR   AlphaFoldDB; A0A2Y9TGW7; -.
DR   Proteomes; UP000248484; Chromosome 10.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006887; P:exocytosis; IEA:InterPro.
DR   CDD; cd04031; C2A_RIM1alpha; 1.
DR   CDD; cd04028; C2B_RIM1alpha; 1.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR039032; Rim-like.
DR   PANTHER; PTHR12157; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN; 1.
DR   PANTHER; PTHR12157:SF18; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 1; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF00595; PDZ; 1.
DR   SMART; SM00239; C2; 2.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS50106; PDZ; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT   DOMAIN          1..84
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          135..258
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          803..921
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          90..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          263..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          316..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          416..460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          500..556
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          604..662
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          674..694
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          710..760
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        282..303
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..337
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        338..358
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..393
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..443
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        518..532
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        710..725
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   957 AA;  105985 MW;  FB8518353EFFC877 CRC64;
     MPKESGALLG LKVVGGKMTD LGRLGAFITK VKKGSLADVV GHLRAGDEVL EWNGKPLPGA
     TNEEVYNIIL ESKSEPQVEI IVSRPIGDIP RIPESSHPPL ESSSSSFESQ KMERPSISVI
     SPTSPGALKD APQVLPGQLS VKLWYDKVGH QLIVNVLQAT DLPPRVDGRP RNPYVKMYFL
     PDRSDKSKRR TKTVKKVLEP KWNQTFVYSH VHRRDFRERM LEITVWDQPR VQEEESEFLG
     EILIELETAL LDDEPHWYKL QTHDESSLPL PQPSPFMPRR HVHGESASKK LQRSQRISDS
     DISDYEVDDA IGVVPPVGYR SSARESKPST LTVPEQQRTT HHRSRSVSPH RGDDQGRPRS
     RLPNVPLQRS LDEIHPTRRS RSPTRHHDVS CSPVGHRPGD VDSQCLSEQD SELLMLPRAK
     RGRSAECLHT TRHSRKSERS STQKQTRKGT ASDAERVLPP CLSRRGYAAP RATDQLVLRG
     KHPARSRSSE HPSVRTLCSM HHLAPGGSAP PSPLLTRVHR QASPTQSPPA DTAFGSPRGR
     QLPQVPVRSG SAEQASLVVE ERTRQMKMKV HRFKQTTGSG SSRELDREQY SKYNVHTDQY
     RSCDSVSARS SDSDVSDVSA ISRTSSTSFL SEQSERPRGR TSSFTPKMQG RRMGTSGRAI
     TKSTSMGGEM YTLEHNDGSQ SDTAVGAVGT GGKKRRSSLS ARVVAIVSRR SRSTSQLSQT
     ESGHKKLKST IQRSTETGMA AEMRKMVRQP SRESTDGSIN SYSSEGNLIF PGVRLGADSQ
     FSDFLDGLGP AQLVGRQTLA TPAMGDIQIG MEDKKGQLEV EVIRARSLTQ KPGSKSTPAP
     YVKVYLLENG ACIAKKKTRI ARKTLDPLYQ QSLVFDESPQ GKVLQVIVWG DYGRMDHKCF
     MGVAQILLEE LDLSSMVIGW YKLFPPSSLV EPTLTPLTRR ASQSSLESST GPPCIRS
//