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Database: UniProt
Entry: A0A2Y9THF5_PHYMC
LinkDB: A0A2Y9THF5_PHYMC
Original site: A0A2Y9THF5_PHYMC 
ID   A0A2Y9THF5_PHYMC        Unreviewed;      3077 AA.
AC   A0A2Y9THF5;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   10-FEB-2021, entry version 13.
DE   SubName: Full=centromere protein F isoform X1 {ECO:0000313|RefSeq:XP_023989667.1, ECO:0000313|RefSeq:XP_023989668.1};
GN   Name=CENPF {ECO:0000313|RefSeq:XP_023989667.1,
GN   ECO:0000313|RefSeq:XP_023989668.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023989668.1};
RN   [1] {ECO:0000313|RefSeq:XP_023989667.1, ECO:0000313|RefSeq:XP_023989668.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_023989667.1,
RC   ECO:0000313|RefSeq:XP_023989668.1};
RG   RefSeq;
RL   Submitted (OCT-2020) to UniProtKB.
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DR   RefSeq; XP_023989667.1; XM_024133899.1.
DR   RefSeq; XP_023989668.1; XM_024133900.1.
DR   Ensembl; ENSPCTT00005005381; ENSPCTP00005004894; ENSPCTG00005003467.
DR   KEGG; pcad:102993182; -.
DR   Proteomes; UP000248484; Genome assembly.
DR   GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 2.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 2.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT   DOMAIN          1..307
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          2094..2233
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2277..2415
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2932..2976
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          211..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          242..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          462..498
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          804..825
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1243..1263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1363..1388
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1664..1687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2854..3077
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          164..191
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          280..384
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          509..543
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          546..615
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          623..706
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          718..752
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          839..873
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          899..957
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          969..989
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1036..1056
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1089..1109
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1118..1159
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1203..1230
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1285..1326
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1578..1616
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1789..1851
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1885..1905
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1955..2034
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2070..2097
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2105..2241
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2287..2423
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2438..2458
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2466..2573
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2581..2619
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2627..2647
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2652..2788
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2799..2826
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        475..498
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1245..1261
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1373..1388
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2854..2895
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2914..2934
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2992..3043
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3077 AA;  353499 MW;  9F8AFE486337C636 CRC64;
     MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
     EGANLKRENQ SLMEICENLE KTKQKISHEL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
     CKSELERSQQ AVQSADVSMS PCITPQKIFV TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
     LEAEVKALQA KKASQAIPQS TMNHRDIARH QASSSVFSWQ QEKTPSRLSS SALKTPIRRD
     FSASNFSGEP EVTPSRSTLQ IGNRDANSSF CDNSSNSHLL DQLKAQNQEL RSKISELELR
     LQGQEREMKG QVNKLQELQI QVEKAKAELN EKEKVLNKSR DELVRTTAQY DQASTKCIAL
     EQKLKKLTED LSCQRQNAES ARCSLEQKIK EKEKEFQEEL SRQQRAFQTL DQEFTQMKAK
     LTQELQQAKN MHNILQAELD KVTSVKHQIE KKLEEFKEKF SRTEQTLQAS QTKENELRRS
     SEEMKRENSL LKGQSEQRAR EVCHLEEELK KAKQRLSQSQ NFAEEMRAKN TSQETMLRDL
     QGKINQQENS LTLEKLKLAL ADLEKQRDCS QDLLKKREHH IEQLNEKLSK TERESEALLS
     ALELKKKEYE ELKKEKTLFS RWKSENEQLL SQMESEKESL QSKINHLETC LKTQQIKSHE
     YNERVRTLEM ERENLNVEIR NLHNVIDSKT AEAETQKQAY GELQQKAEFS DQKHEKEIEN
     MCLKISQLTG QVEDLEDKLQ LLSSEIMDKD QRYQDLHAES ESLRDLLKSR YSSVVTNESH
     QRSLLAFEQQ SAVNNSFANI IEEQESVPSE RSECHLETDQ SPKSSSILQN RVVSLEFSLE
     SQKQMNSDLQ KQCEELAQIK GEIEENLMKA EQMHQSFVAE TSQRISKLQE DTSVHQNVVV
     ETLVALESKE RELQLLNEKL ETEQAEIQEL KKSNHLLQES LKELQLLSET LSLEKKEMSS
     IISLDKEDIE ELTQENGTLK EINATLTQEK MNLLQKTESL SNCIDERDKS ISELSDQYKQ
     ERFTLLQRCE ETGNAFRDLS EKYKAEQEKN SKLECLLNEC TSVCEDRKNE LGQLKETFAR
     EHQAFVSQLA LAEERNQSLI RELETVQQAL RSEIPDIQSN SKREADGLKQ EIMTLKEEQS
     KMQQEINALL QEKEHLMELM KTKHEHQHLE LEPIQDSVKV AERKINTCHV QLLMDLEVKD
     TSLDSYNAQL AQVETKVRNM ELKLQQSEKE EYLQHELQIR GELETGDVQQ GTQSQDISGL
     GNSEIDPEEK YISVLHELST SQQDNAHLQC SLHTAMNKLD ELEKMCEALQ MEKLELLSEL
     NDSRSECVTA TSKMAEEVGK LVNEVKILND ENRLLQGEFV KETPESEFDE QQDEQTSVSS
     NPLDDSNSYE HLTVSNKEVH MHFAELQEKF SSLQSEHKIL HDQHCQMSSK MSELQSYIDT
     LKAENSVLST SLRNSQGDLV KEVMPGPGEK HFLSLSLSGV TDSPGNAIES SFYKDLLDHM
     GETSLLNNLD RTVLANQSSV EEVSCSSLEG ENLTEKEIPS APVRSVEELG TVCQMYLQSF
     KKLEEKIESQ GITKNKEIEE LERLLSSSRE ELDCLRKQYL SENEQWQQKL TSVTAEMESK
     LAAEKKHTEH LTLELEVARL QLQGLDLSSR SLLGTDIEDA IRGGNDSCDI SESEEYTSET
     KERTPKHEIH QICEKDVQQD LSLEMEKITK MSAIKLLGEW SREQSPETSH GTPVEDTTQG
     CSECISELSL SGPDASVPMD FLENQVTIQN LQLQVKETSN EKLRLLHGIK ERDQKVESLL
     NEIKELDSKL NLQEVQLTTK IEACIELEKI VEELKKEKSD FSEILESFSR DNQRVESSGG
     LTSNLEMGTD KLSHEGTEDE VAKVTDNWRE RCLNVENELQ RMKAERGSTE HHALSAEANL
     EVVQTEKLFL EKDNENKQKV ITCLEEGLLV VTSERDQLRG ELDTLSKENQ ELDQMSEKMK
     EKIRELESHQ DECLHLQEQL RSLEKDSQAL SLVRSELENQ IRQLNKETES LVRESESRQT
     KLSELEHEKL TVAKALEAAL MEKGEVAVRL SSTQEEVHQL RKGIEKLRVR IEADEKKQLH
     ISEKLKESER RNDSLQDKVE TLERELHMAE ENQELVILDA ENSKAEVETL KTQMELMTES
     LKALDLDLVT TRSEKENLVK QLQEKQGQVS ELHTLLSSLK NVLEEKEREK IQMKEESKAV
     VEILQTQLKE LSEEVAVLCD DQETWKVEEQ SLDSPVQEVH QLRNNIGKLK VHLDTNERKQ
     LHILEKLKES EHQAALLKDT VENLERELEV SGKNQEHAIL EAEKSNAEVE TLKAKIEEMA
     QNLGALELDL VNTRSEKEDL TKELQKEQGR VSELETLNSS FENLLQEKEQ EKEQMKEESK
     AVVEILQTQL KELSEEVAAL CDDQETWKVE EQSLSSQVDS LEHEKAQLLQ GLDEAKSNYM
     LLQSSVNGLV QEVEDGKQKL EKKDEEIRML KNHIQDQEQL VSKLSQMERE QQLWEEQRTK
     LENLMVELEQ RTQVLQSKND TLQDTLEALQ NSSKDLEKEL ELTKMEKRSF DEKVNTMTVK
     EAELQKEMHA MVQKTAELKE EFSREKNRLT KDLKLVSEEI KSRKGQLKEL MLENSELKKS
     LDCVHKDQME KQGKMREEIA EYQLRLQEAE KKHQALLLDI NKQYEMEIQT YREKLTSKEE
     CLSSQKVEID LLKSSKEELN NSLKVTTEIL EELKKTKMEN LKYADKLKKE NDRAQGKIKL
     LIKSCKQLEE EKEMLQKEIS HLEAAQEKQK AGTVVDANID ELMTKMKELK ETLEEKNKEA
     DEYLDKYCSL LISHEKLEKA KEMLETQVAR LSSQQSKLNL RSSPSLNSVV PGPSPVPSAT
     EKKSSSGQNK ASGKRQRSGG IREDGGETTP STPEKFSKKS RKVFKSGIHP AEDAEDAEPE
     PEGLPEVVKK GFADIPTGKT SPYILRRTTM VTRTSPRLAA RKLAPSPLSL DKENLAETSK
     PTAGGSRSQK VKVTQQSPVD SGTALREPTT RSLSISNLPE RSSADSPREG LRAKQGRLAP
     SPEAGPESKG SENCRVQ
//
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