ID A0A2Y9THF5_PHYMC Unreviewed; 3077 AA.
AC A0A2Y9THF5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 10-FEB-2021, entry version 13.
DE SubName: Full=centromere protein F isoform X1 {ECO:0000313|RefSeq:XP_023989667.1, ECO:0000313|RefSeq:XP_023989668.1};
GN Name=CENPF {ECO:0000313|RefSeq:XP_023989667.1,
GN ECO:0000313|RefSeq:XP_023989668.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023989668.1};
RN [1] {ECO:0000313|RefSeq:XP_023989667.1, ECO:0000313|RefSeq:XP_023989668.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023989667.1,
RC ECO:0000313|RefSeq:XP_023989668.1};
RG RefSeq;
RL Submitted (OCT-2020) to UniProtKB.
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DR RefSeq; XP_023989667.1; XM_024133899.1.
DR RefSeq; XP_023989668.1; XM_024133900.1.
DR Ensembl; ENSPCTT00005005381; ENSPCTP00005004894; ENSPCTG00005003467.
DR KEGG; pcad:102993182; -.
DR Proteomes; UP000248484; Genome assembly.
DR GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 2.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 2.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT DOMAIN 1..307
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 2094..2233
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2277..2415
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2932..2976
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 211..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1243..1263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1363..1388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1664..1687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2854..3077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 164..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 280..384
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 509..543
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 546..615
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 623..706
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 718..752
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 839..873
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 899..957
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 969..989
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1036..1056
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1089..1109
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1118..1159
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1203..1230
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1285..1326
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1578..1616
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1789..1851
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1885..1905
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1955..2034
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2070..2097
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2105..2241
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2287..2423
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2438..2458
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2466..2573
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2581..2619
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2627..2647
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2652..2788
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2799..2826
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 475..498
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1245..1261
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1373..1388
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2854..2895
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2914..2934
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2992..3043
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3077 AA; 353499 MW; 9F8AFE486337C636 CRC64;
MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
EGANLKRENQ SLMEICENLE KTKQKISHEL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
CKSELERSQQ AVQSADVSMS PCITPQKIFV TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
LEAEVKALQA KKASQAIPQS TMNHRDIARH QASSSVFSWQ QEKTPSRLSS SALKTPIRRD
FSASNFSGEP EVTPSRSTLQ IGNRDANSSF CDNSSNSHLL DQLKAQNQEL RSKISELELR
LQGQEREMKG QVNKLQELQI QVEKAKAELN EKEKVLNKSR DELVRTTAQY DQASTKCIAL
EQKLKKLTED LSCQRQNAES ARCSLEQKIK EKEKEFQEEL SRQQRAFQTL DQEFTQMKAK
LTQELQQAKN MHNILQAELD KVTSVKHQIE KKLEEFKEKF SRTEQTLQAS QTKENELRRS
SEEMKRENSL LKGQSEQRAR EVCHLEEELK KAKQRLSQSQ NFAEEMRAKN TSQETMLRDL
QGKINQQENS LTLEKLKLAL ADLEKQRDCS QDLLKKREHH IEQLNEKLSK TERESEALLS
ALELKKKEYE ELKKEKTLFS RWKSENEQLL SQMESEKESL QSKINHLETC LKTQQIKSHE
YNERVRTLEM ERENLNVEIR NLHNVIDSKT AEAETQKQAY GELQQKAEFS DQKHEKEIEN
MCLKISQLTG QVEDLEDKLQ LLSSEIMDKD QRYQDLHAES ESLRDLLKSR YSSVVTNESH
QRSLLAFEQQ SAVNNSFANI IEEQESVPSE RSECHLETDQ SPKSSSILQN RVVSLEFSLE
SQKQMNSDLQ KQCEELAQIK GEIEENLMKA EQMHQSFVAE TSQRISKLQE DTSVHQNVVV
ETLVALESKE RELQLLNEKL ETEQAEIQEL KKSNHLLQES LKELQLLSET LSLEKKEMSS
IISLDKEDIE ELTQENGTLK EINATLTQEK MNLLQKTESL SNCIDERDKS ISELSDQYKQ
ERFTLLQRCE ETGNAFRDLS EKYKAEQEKN SKLECLLNEC TSVCEDRKNE LGQLKETFAR
EHQAFVSQLA LAEERNQSLI RELETVQQAL RSEIPDIQSN SKREADGLKQ EIMTLKEEQS
KMQQEINALL QEKEHLMELM KTKHEHQHLE LEPIQDSVKV AERKINTCHV QLLMDLEVKD
TSLDSYNAQL AQVETKVRNM ELKLQQSEKE EYLQHELQIR GELETGDVQQ GTQSQDISGL
GNSEIDPEEK YISVLHELST SQQDNAHLQC SLHTAMNKLD ELEKMCEALQ MEKLELLSEL
NDSRSECVTA TSKMAEEVGK LVNEVKILND ENRLLQGEFV KETPESEFDE QQDEQTSVSS
NPLDDSNSYE HLTVSNKEVH MHFAELQEKF SSLQSEHKIL HDQHCQMSSK MSELQSYIDT
LKAENSVLST SLRNSQGDLV KEVMPGPGEK HFLSLSLSGV TDSPGNAIES SFYKDLLDHM
GETSLLNNLD RTVLANQSSV EEVSCSSLEG ENLTEKEIPS APVRSVEELG TVCQMYLQSF
KKLEEKIESQ GITKNKEIEE LERLLSSSRE ELDCLRKQYL SENEQWQQKL TSVTAEMESK
LAAEKKHTEH LTLELEVARL QLQGLDLSSR SLLGTDIEDA IRGGNDSCDI SESEEYTSET
KERTPKHEIH QICEKDVQQD LSLEMEKITK MSAIKLLGEW SREQSPETSH GTPVEDTTQG
CSECISELSL SGPDASVPMD FLENQVTIQN LQLQVKETSN EKLRLLHGIK ERDQKVESLL
NEIKELDSKL NLQEVQLTTK IEACIELEKI VEELKKEKSD FSEILESFSR DNQRVESSGG
LTSNLEMGTD KLSHEGTEDE VAKVTDNWRE RCLNVENELQ RMKAERGSTE HHALSAEANL
EVVQTEKLFL EKDNENKQKV ITCLEEGLLV VTSERDQLRG ELDTLSKENQ ELDQMSEKMK
EKIRELESHQ DECLHLQEQL RSLEKDSQAL SLVRSELENQ IRQLNKETES LVRESESRQT
KLSELEHEKL TVAKALEAAL MEKGEVAVRL SSTQEEVHQL RKGIEKLRVR IEADEKKQLH
ISEKLKESER RNDSLQDKVE TLERELHMAE ENQELVILDA ENSKAEVETL KTQMELMTES
LKALDLDLVT TRSEKENLVK QLQEKQGQVS ELHTLLSSLK NVLEEKEREK IQMKEESKAV
VEILQTQLKE LSEEVAVLCD DQETWKVEEQ SLDSPVQEVH QLRNNIGKLK VHLDTNERKQ
LHILEKLKES EHQAALLKDT VENLERELEV SGKNQEHAIL EAEKSNAEVE TLKAKIEEMA
QNLGALELDL VNTRSEKEDL TKELQKEQGR VSELETLNSS FENLLQEKEQ EKEQMKEESK
AVVEILQTQL KELSEEVAAL CDDQETWKVE EQSLSSQVDS LEHEKAQLLQ GLDEAKSNYM
LLQSSVNGLV QEVEDGKQKL EKKDEEIRML KNHIQDQEQL VSKLSQMERE QQLWEEQRTK
LENLMVELEQ RTQVLQSKND TLQDTLEALQ NSSKDLEKEL ELTKMEKRSF DEKVNTMTVK
EAELQKEMHA MVQKTAELKE EFSREKNRLT KDLKLVSEEI KSRKGQLKEL MLENSELKKS
LDCVHKDQME KQGKMREEIA EYQLRLQEAE KKHQALLLDI NKQYEMEIQT YREKLTSKEE
CLSSQKVEID LLKSSKEELN NSLKVTTEIL EELKKTKMEN LKYADKLKKE NDRAQGKIKL
LIKSCKQLEE EKEMLQKEIS HLEAAQEKQK AGTVVDANID ELMTKMKELK ETLEEKNKEA
DEYLDKYCSL LISHEKLEKA KEMLETQVAR LSSQQSKLNL RSSPSLNSVV PGPSPVPSAT
EKKSSSGQNK ASGKRQRSGG IREDGGETTP STPEKFSKKS RKVFKSGIHP AEDAEDAEPE
PEGLPEVVKK GFADIPTGKT SPYILRRTTM VTRTSPRLAA RKLAPSPLSL DKENLAETSK
PTAGGSRSQK VKVTQQSPVD SGTALREPTT RSLSISNLPE RSSADSPREG LRAKQGRLAP
SPEAGPESKG SENCRVQ
//
