ID   A0A2Y9TIL4_PHYMC        Unreviewed;       599 AA.
AC   A0A2Y9TIL4;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Lamin-B2 {ECO:0000313|RefSeq:XP_023990198.1};
GN   Name=LMNB2 {ECO:0000313|RefSeq:XP_023990198.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023990198.1};
RN   [1] {ECO:0000313|RefSeq:XP_023990198.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_023990198.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus lamina {ECO:0000256|ARBA:ARBA00024186}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   RefSeq; XP_023990198.1; XM_024134430.3.
DR   AlphaFoldDB; A0A2Y9TIL4; -.
DR   STRING; 9755.ENSPCTP00005028240; -.
DR   KEGG; pcad:102995268; -.
DR   InParanoid; A0A2Y9TIL4; -.
DR   OrthoDB; 72418at2759; -.
DR   Proteomes; UP000248484; Chromosome 2.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR   GO; GO:0005652; C:nuclear lamina; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR001322; Lamin_tail_dom.
DR   InterPro; IPR036415; Lamin_tail_dom_sf.
DR   PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR   PANTHER; PTHR45721:SF2; LAMIN-B2; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF00932; LTD; 1.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
DR   PROSITE; PS51841; LTD; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023289};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT   DOMAIN          26..382
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   DOMAIN          440..557
FT                   /note="LTD"
FT                   /evidence="ECO:0000259|PROSITE:PS51841"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          378..442
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          561..599
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          23..205
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          237..357
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        386..411
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        428..442
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   599 AA;  67583 MW;  66802E6C20D359E7 CRC64;
     MATPPPGRAG GPATPLSPTR LSRLQEKEEL RELNDRLAHY IDRVRALELE NDRLQLKISE
     REEVTTREVS GIKTLYEAEL ADARRVLDET ARDRARLQIE IGKLRADLEE ASKSAKKREG
     ELTVAQGRVR DLESVFHQSE AELAAALSDK RALENDVVEL RAQLGKAEDG HAVAKKQLEK
     ETLMRVDLEN RCQSLQEELA FRKDVFEEEV RETRRRHERR LVEVDSSRQQ EYDFKMAQAL
     EELRAQHDEQ VRLYRLELEQ TYQAKLDNAK LSSDQNDKAA SAAREELKEA RMRVESLSYQ
     LSGLQKQANA AEDRIRELEE TVAGERDKFR KMLDAKEREM TEMRDVMQQQ LAEYQELLDV
     KLALDMEISA YRKLLEGEEE RLKLSPSPSS RITISRATSS SSSSSVSVSG RLGRSKRKRL
     EVEEPPGTGS SGTGSGSSSF RLAQQASASG SVSIEEIDLE GRFVQLKNSS DKDQSLGNWR
     IKRQILEGEE IAYKFTPKYV LRAGQTVTVW AAGAGVAHSP PSTLVWKSQN SWGTGESFRT
     ILVNADGEEV AMRTVKQSSV VREAEDGEEG EDEAAEFGEE DLFHQQGDPR TTSRGCRVM
//