ID A0A2Y9TJT1_PHYMC Unreviewed; 1640 AA.
AC A0A2Y9TJT1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Neurexin-2-beta isoform X2 {ECO:0000313|RefSeq:XP_023989009.1};
GN Name=NRXN2 {ECO:0000313|RefSeq:XP_023989009.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023989009.1};
RN [1] {ECO:0000313|RefSeq:XP_023989009.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_023989009.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_023989009.1; XM_024133241.2.
DR Ensembl; ENSPCTT00005022339; ENSPCTP00005020284; ENSPCTG00005013609.
DR Proteomes; UP000248484; Chromosome 16.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00110; LamG; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR15036:SF49; AXOTACTIN; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF02210; Laminin_G_2; 6.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00282; LamG; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1640
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016110424"
FT TRANSMEM 1566..1586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..204
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 200..240
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 263..453
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 460..653
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 657..694
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 699..862
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 876..1051
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1054..1091
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1095..1273
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1390..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1453..1554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1608..1640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1503..1529
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1624..1640
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1640 AA; 176892 MW; 1186D5E8F8FD1446 CRC64;
MAPGNPWRPP SLPLLLLLTL AAGAGGLEFG GGPGQWARYA RWAGAASSGE LSFSLRTNAT
RALLLYLDDG GDCDFLELLL VEGRLRLRFT LSCAEPATLQ LDTLVADDRW HMVLLTRDAR
RTALAVDGEA RAAEVRSKRR EMQVASDLFV GGIPPDVRLS ALTLSTVKYE PPFSGLLANL
KLGERPPALL GSQGLRGAAA DPLCAPARNP CANGGLCTVL APGEVGCDCS HTGFGGKFCS
EEERPMEGPA HLTLNSEGKE EFVATFKGNE FFCYDLSHNP IQSSTDEITL AFRTLQRNGL
MLHTGKSADY VNLSLKSGAV WLVINLGSGA FEALVEPVNG KFNDNAWHDV RVTRNLRQHA
GIGHAMVTIS VDGILTTTGY TQEDYTMLGS DDFFYIGGSP NTADLPGSPV SNNFMGCLKD
VVYKNNDFKL ELSRLAKEGD PKMKLQGDLS FRCEDVAALD PVTFESPEAF VALPRWSAKR
TGSISLDFRT TEPNGLLLFS QGRRAGAGAS SHSAARRADY FAMELLDGYL YLLLDMGSGG
IKLRASSRKV NDGEWCHVDF QRDGRKGSIS VNSRSTPFLA TGESEILDLE SELYLGGLPE
GGRVDLPPPP EVWTAALRAG YVGCVRDLFI DGRSRDLRGL AEAQGAVGVA PFCSRETLKQ
CTSAPCRNGG VCREGWNRFV CDCVGTGFLG RVCEREATVL SYDGSMYMKI MLPHAMHTEA
EDVSLRFMSQ RAYGLMMATT SRESADTLRL ELDGGQMKLT VNLGKGPETL FAGHKLNDNE
WHTVRVVRRG KSLQLSVDNV TVEGQMAGAH TRLEFHNIET GIMTERRFIS VVPSNFIGHL
SGLVFNGQPY MDQCKDGDIT YCELNARFGL RAIVADPVTF KSRSSYLALA TLQAYASMHL
FFQFKTTAPD GLLLFNSGNG NDFIVIELVK GYIHYVFDLG NGPSLMKGNS DKPVNDNQWH
NVVVSRDPGN VHTLQIDSRT VTQHSNGARN LDLKGELYIG GLSKNMFNNL PKLVASRDGF
QGCLASVDLN GRLPDLIADA LHRIGQVERG CDGPSTTCTE ESCANQGVCL QQWDGFTCDC
TMTSYGGPVC NDPGTTYIFG KGGALITYTW PPNDRPSTRM DRLAVGFSTH QRSAVLVRVD
SASGLGDYLQ LHIDQGTVGV IFNVGTDDIT IDEPNAIVSD GKYHVVRFTR SGGNATLQVD
SWPVNERYPA GRQLTIFNSQ AAIKIGGRDQ GRPFQGQVSG LYYNGLKVLA LAAESDPNVR
TEGHLRLVGE GPSVLLSAET TATTLLADMA TTIMETTTTM ATTTTRRGRS PTLRDSTTQN
TDDLLVASAE CPSDDEDLEE CEPSTGGELI LPIITEDSLD PPPVATRSPF VPPPPTFYPF
LTGVGATQDT LPPPAARRPP AGGPCQAEQD DSDCEEPIEA SGFASGEVFD SSLPPTDDED
FYTTFPLVTD RTTLLSPRKP APRPNLRTDG ATGAPGVLLA PSAPAPNLPA GKMNHRDPLQ
PLLENPPLGP GAPTSFEPRR PPPLRPGVTS APGFPHLPTA NPTGPGERGP PGAVEVIRES
SSTTGMVVGI VAAAALCILI LLYAMYKYRN RDEGSYQVDQ SRNYIGNSAQ SNGAVVKEKA
PAAPKTPSKA KKNKDREYYV
//
