ID   A0A2Z2HTC0_9EURY        Unreviewed;       657 AA.
AC   A0A2Z2HTC0;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE            EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN   ORFNames=B1756_02050 {ECO:0000313|EMBL:ARS88657.1};
OS   Natrarchaeobaculum aegyptiacum.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC   Natrialbaceae; Natrarchaeobaculum.
OX   NCBI_TaxID=745377 {ECO:0000313|EMBL:ARS88657.1, ECO:0000313|Proteomes:UP000250088};
RN   [1] {ECO:0000313|Proteomes:UP000250088}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JW/NM-HA 15 {ECO:0000313|Proteomes:UP000250088};
RA   Zhao B.;
RT   "Natronthermophilus aegyptiacus gen. nov.,sp. nov., an aerobic, extremely
RT   halophilic alkalithermophilic archaeon isolated from the athalassohaline
RT   Wadi An Natrun, Egypt.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP019893; ARS88657.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2Z2HTC0; -.
DR   KEGG; naj:B1756_02050; -.
DR   OrthoDB; 190277at2157; -.
DR   Proteomes; UP000250088; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000250088}.
FT   DOMAIN          36..86
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          89..474
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          541..620
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   657 AA;  73002 MW;  92F967443041667D CRC64;
     MGNERPDWRL ETAPARRRRQ PVAFSREAEP LAKDCRERFD REWPDCWMAA AAELDWHEPP
     EAVLDDSDAP FYRWFPDGRL NAAENCVDRH LEDRKNQLAI RWEGKRGEKR DYTYHDLHRE
     STALAATLRD LGVSEGDVVT FALPTLPELP IGMLACARIG ALHNVVFAGF APDALVERMT
     AVDSSALVTC DGYYRDGLAI DQKRKTDAAL AALESTVPTV VVDRLGASHE VELEAHQYDY
     DDLIDQYRGT DVEPVSRAAT DPLFHIHTSG TTGEPQRMTH ATGGYLAGVT WSARAVFDLA
     PGTTYWCTAD VGWITGHSYV VYGPLARGAT VVLAEGNPRY PARHRPWKII ERNGVEVFYT
     TPGMVRTFMK WGESFPAAHD KSSLRLLGTV GEPIGPDTWK WYYTHVGEER CPIVDTWWQT
     ETGSVVLSTL PGVDEMKPGA AGPPLPGMDV SVVDDEGREL PPGEPGYLTI ERPWPSMLAP
     LESDHYWVLA EYWQEFSDDR ADSWRYITGD RAVADEDGYV TIIGRADEVV TIGNRRLGTA
     ELEAAITSVE GVTEAAAVAG SADGDTDLYV FATTAQERDT RDRAAIREAV ADAMAERVGE
     FARPAAVVFT PELPETHSGK TMYRILERIV EDRPLEDSAP LRNPEIVGEI ATLWARE
//