ID A0A2Z2HZ75_9EURY Unreviewed; 397 AA.
AC A0A2Z2HZ75;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Mechanosensitive ion channel protein {ECO:0000313|EMBL:ARS88958.1};
GN ORFNames=B1756_03775 {ECO:0000313|EMBL:ARS88958.1};
OS Natrarchaeobaculum aegyptiacum.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natrarchaeobaculum.
OX NCBI_TaxID=745377 {ECO:0000313|EMBL:ARS88958.1, ECO:0000313|Proteomes:UP000250088};
RN [1] {ECO:0000313|Proteomes:UP000250088}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JW/NM-HA 15 {ECO:0000313|Proteomes:UP000250088};
RA Zhao B.;
RT "Natronthermophilus aegyptiacus gen. nov.,sp. nov., an aerobic, extremely
RT halophilic alkalithermophilic archaeon isolated from the athalassohaline
RT Wadi An Natrun, Egypt.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
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DR EMBL; CP019893; ARS88958.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2Z2HZ75; -.
DR KEGG; naj:B1756_03775; -.
DR OrthoDB; 31543at2157; -.
DR Proteomes; UP000250088; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR045275; MscS_archaea/bacteria_type.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR PANTHER; PTHR30221; SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL; 1.
DR PANTHER; PTHR30221:SF1; SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000250088};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 22..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 208..272
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 280..364
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 373..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 397 AA; 43010 MW; 53E0EAB602E1664F CRC64;
MNEHTAAIGA TLESVTTTEA RLLVTATVVL ATLVIGFVLI PVVVRRVVHH VGRRLEASEA
GSLLETIDDL LSVPFPMRAV IRTIQSAILL AAALVGLVVW GYLEVAATIL SVLAAAVPYA
LRIFLTVGLL GGAVVGTRYL EERLDDWLAD ANYVTAHQEG VVFRVLQVTI FVAVGLSAIS
LWGVDLGGLL VGAGFLGIVM GMAAQQTLGS LIAGFVLMFS RPFEIGDWVE IGEFEGMVVD
ITIINTRLRS FDGETIVLPN DEVSSATVVN RSKRDRLRLT LEVGVDYETD LEHAEEVAIE
AMESVDDVSP APRPKVIPTT FGDSAITLEC RFWIRQPNAH RKWTTIQSVI HELKAAYDRE
EIGIPYPQRE LSARAGGGLQ VPDTESGDTA LSYDEQH
//
