ID A0A2Z2K6V6_9BACL Unreviewed; 910 AA.
AC A0A2Z2K6V6;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=B9T62_15220 {ECO:0000313|EMBL:ASA22006.1};
OS Paenibacillus donghaensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=414771 {ECO:0000313|EMBL:ASA22006.1, ECO:0000313|Proteomes:UP000249890};
RN [1] {ECO:0000313|EMBL:ASA22006.1, ECO:0000313|Proteomes:UP000249890}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 13049 {ECO:0000313|EMBL:ASA22006.1,
RC ECO:0000313|Proteomes:UP000249890};
RA Jung B.K., Hong S.-J., Shin J.-H.;
RT "Complete genome sequence of Paenibacillus donghaensis KCTC 13049T isolated
RT from East Sea sediment, South Korea.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP021780; ASA22006.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2Z2K6V6; -.
DR KEGG; pdh:B9T62_15220; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000249890; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000249890}.
FT DOMAIN 685..701
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 611..618
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 910 AA; 100479 MW; 60CAC29B6E37C092 CRC64;
MAEYTPMIQQ YLQVKEGAKD AFLFFRLGDF YEMFFDDAIL ASKELEITLT ARGGGGDGKI
PMCGVPYHAA EGYIQRLIEK GYKVAICEQL EDPATTKGMV RRDIVRVVTP GTVMEGKIIS
DKSNNYLVCV TESDGMMALS ACDLTTGELY VTSVLSGAEW LRDEIGIYEP AEVIGDALLL
DQLRSESSLL AKPVVYTPWE KRDEELARRQ FGEAAWVRLE KERGRNLSLL ISYLSETQRR
SLAQLSQISP YEPGHYMILD PFTRRNLELT ETVRERSKKG SLLWLLDRTE TSMGARLLRR
RIDKPLLQRA PIERRLEAVD YLYNQFIMRE DLRLSLKEIY DLERLVGRIA FGSANGRDMN
ALKLSLAQIP ALKQLCMTSG SATLREIGEA MDECAELRED IGQAIVDEAP VSVRDGGIIR
AGYHERLDEL REASTNGKRW IAELEAKERL ATGIKSLKIG YNKIFGYYIE ITRSNLAALP
EGRYERKQTL ANAERFVTPE LKEKEALILE AQDKMTDLEY SLFIALRDRI SSQIPRLQNL
AEQVAEIDVY QCLAAVSAEH RFVKPKLSDG YDLRIEGGRH PVVEAVLKES AFIANGSTLA
KEDGNILLIT GPNMAGKSTY MRQVALICIL AQIGCFVPAA SAEVPLIDRI FTRIGAADDL
IGGQSTFMVE MADIQVMTEK ATARSLIIID ELGRGTSTSE GMAIAQAVIE YVHDTIACKA
LVSTHFHELA HLQESLLGLR NYSMAVQESG DKVNFLRKLV PGAADSSYGI YCARLAGLPE
GIIDRAYGLL QSIEQAAPPG AAVVAGGEVQ AGNVAPAPAA AAQAESAYKE AAVSLEPNLL
EESSEVVQLS IFGEEPPRRG RKAAAAAPAA EDNPLLKAFI ASVRDADLMN MTPLQQMGLL
NDLKMKAREL
//
