ID   A0A2Z2P3C9_9GAMM        Unreviewed;       848 AA.
AC   A0A2Z2P3C9;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Hydrogenase-4 component A {ECO:0000313|EMBL:ASJ74284.1};
DE            EC=1.-.-.- {ECO:0000313|EMBL:ASJ74284.1};
GN   Name=hyfA {ECO:0000313|EMBL:ASJ74284.1};
GN   ORFNames=IMCC3135_21035 {ECO:0000313|EMBL:ASJ74284.1};
OS   Granulosicoccus antarcticus IMCC3135.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC   Granulosicoccaceae; Granulosicoccus.
OX   NCBI_TaxID=1192854 {ECO:0000313|EMBL:ASJ74284.1, ECO:0000313|Proteomes:UP000250079};
RN   [1] {ECO:0000313|EMBL:ASJ74284.1, ECO:0000313|Proteomes:UP000250079}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IMCC3135 {ECO:0000313|EMBL:ASJ74284.1,
RC   ECO:0000313|Proteomes:UP000250079};
RA   Song W.-J., Kurnit D.M.;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP018632; ASJ74284.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2Z2P3C9; -.
DR   KEGG; gai:IMCC3135_21035; -.
DR   OrthoDB; 9779457at2; -.
DR   Proteomes; UP000250079; Chromosome.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd00038; CAP_ED; 2.
DR   CDD; cd16367; DMSOR_beta_like; 1.
DR   Gene3D; 3.30.70.20; -; 2.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR42859:SF10; ELECTRON TRANSPORT PROTEIN HYDN-RELATED; 1.
DR   PANTHER; PTHR42859; OXIDOREDUCTASE; 1.
DR   Pfam; PF00027; cNMP_binding; 2.
DR   Pfam; PF13247; Fer4_11; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PRINTS; PR00368; FADPNR.
DR   PRINTS; PR00469; PNDRDTASEII.
DR   SMART; SM00100; cNMP; 2.
DR   SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 3.
DR   PROSITE; PS50042; CNMP_BINDING_3; 2.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000313|EMBL:ASJ74284.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000250079}.
FT   DOMAIN          391..507
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          524..626
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          673..704
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          709..741
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          742..770
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
SQ   SEQUENCE   848 AA;  92771 MW;  BF17FD5838DA61D8 CRC64;
     MSSHYHIAII GSGPAGLSAA ARAAQKDQEA GRNEPTHVLL EAFPLHAKTI QQYQKGKYVM
     AEPGYLNLRS DCEFEQGTRE NILDHWSQNL TDNKVNCLYS SEVSKVTGEQ GNFTIQIGNG
     TSLSAENIVL AIGVQGNPRK LGSPGSEHPL VQYQLDDPDE YHGEHIIVVG AGDAAIENAV
     ALTANNKVSI LNRKDEFSRA KEGNLNGILA AISDEKVALE CFYSSSVKLV EPDSDDPKLL
     HVTLNTSEGE IKVDAHRIIA RLGAIPQRAF VESMGIEFPN KKPETMPELD NHYQSNVPGI
     YIVGALAGYP LIKQAMNQGY DVVEFINGNE IDPADHPLLE YRFAGLPFRL DVNEQVHRLQ
     QIIPMLSQLN SLQFRELLIE SSMIASYPPG LEQKEAETRL AEIAKTLGGS KTELRITELL
     KEGDTLYEPG QFGTSFYTIV AGEVQIEKWL ETGESVKSTL KRGEFFGEMS LLSGHPRLER
     ASAGVGCILI ETPRRIMLKL ISSNEEVAAG IEWLFVVREL QRHFAPRAPT SELRALSANL
     EIRRMQAGEF LYEQGSEEEC LYLIKSGGIT LSKNVNGEEI FISQVRAGKM VGQISLMGDP
     IRRQSAVATV VSEAIRIDRQ TFNTLMQRSD APIATLQGYV TEQIAVDTRM EVRPEAAASM
     NFLMKNGLGE ATNTLIIDES LCVGCDNCEK ACAETHNGIT RLDRREGPTF ANIHIPTSCR
     HCEQPHCMKD CPPNAIRRAE SGEVFINDSC IGCGNCQINC PYDVIRMVKP PAKKPGLISW
     MLLGLGTGPG ESKNSQKGGS PSAVKKAVKC DACVDLPAGP ACVNACPTGA AMRIGPAQFV
     ELVEEKQR
//