ID A0A2Z3GTC6_9BACT Unreviewed; 438 AA.
AC A0A2Z3GTC6;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=NADH:ubiquinone reductase (non-electrogenic) {ECO:0000256|ARBA:ARBA00012637};
DE EC=1.6.5.9 {ECO:0000256|ARBA:ARBA00012637};
GN ORFNames=C1280_01175 {ECO:0000313|EMBL:AWM35771.1};
OS Gemmata obscuriglobus.
OC Bacteria; Planctomycetota; Planctomycetia; Gemmatales; Gemmataceae;
OC Gemmata.
OX NCBI_TaxID=114 {ECO:0000313|EMBL:AWM35771.1, ECO:0000313|Proteomes:UP000245802};
RN [1] {ECO:0000313|EMBL:AWM35771.1, ECO:0000313|Proteomes:UP000245802}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5831 {ECO:0000313|EMBL:AWM35771.1,
RC ECO:0000313|Proteomes:UP000245802};
RA Franke J., Blomberg W., Selmecki A.;
RT "G. obscuriglobus.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + H(+) + NADH = a quinol + NAD(+);
CC Xref=Rhea:RHEA:46160, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; EC=1.6.5.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000864};
CC -!- SIMILARITY: Belongs to the NADH dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00005272}.
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DR EMBL; CP025958; AWM35771.1; -; Genomic_DNA.
DR RefSeq; WP_010043884.1; NZ_CP042911.1.
DR AlphaFoldDB; A0A2Z3GTC6; -.
DR KEGG; gog:C1280_01175; -.
DR OrthoDB; 9781621at2; -.
DR Proteomes; UP000245802; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006116; P:NADH oxidation; IEA:InterPro.
DR Gene3D; 3.50.50.100; -; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR045024; NDH-2.
DR PANTHER; PTHR43706:SF3; EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43706; NADH DEHYDROGENASE; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000245802};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..338
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
SQ SEQUENCE 438 AA; 47204 MW; 07A2DA234847DB64 CRC64;
MSDGTTAHKV VIIGGGFGGL VAAQALNKTP TEVTLIDRRN FHLFQPLLYQ VATGALSPAN
IASPLRSILK RQKNTHVLLG EVTGFDVPAK AVLLKDGTRV PFDTLIVATG STHHYFGKTD
WAERAPGLKT IEDATEVRRR VLSAFERAER ATDPKERARQ LTFVVVGGGP TGVEMAGAIS
ELAKHTLRAD FRSVDPATSR IVLIEGQPKV LGAFHERLSA KALKALQGMG IEVMLDAHVN
AIEPHYVLVQ PDDKAAAPVR IDTETVVWAA GVKASPLGQV LADAIGGVTV GRGGHVPVNP
DCTVGNRPDI FVIGDMASLP GANGKPLPGV APVATQQGEY VAGVIVRRLK GETPKGPFRY
FDKGTMATIG RGQAVAESMG FRFSGLLAWL AWLFIHIMYL ARFENRMLVL FQWFWNYVTR
NRTARLITGE RPTGTRGA
//
