ID   A0A2Z3H0Q3_9BACT        Unreviewed;       910 AA.
AC   A0A2Z3H0Q3;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=C1280_27335 {ECO:0000313|EMBL:AWM40349.1};
OS   Gemmata obscuriglobus.
OC   Bacteria; Planctomycetota; Planctomycetia; Gemmatales; Gemmataceae;
OC   Gemmata.
OX   NCBI_TaxID=114 {ECO:0000313|EMBL:AWM40349.1, ECO:0000313|Proteomes:UP000245802};
RN   [1] {ECO:0000313|EMBL:AWM40349.1, ECO:0000313|Proteomes:UP000245802}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 5831 {ECO:0000313|EMBL:AWM40349.1,
RC   ECO:0000313|Proteomes:UP000245802};
RA   Franke J., Blomberg W., Selmecki A.;
RT   "G. obscuriglobus.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
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DR   EMBL; CP025958; AWM40349.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2Z3H0Q3; -.
DR   KEGG; gog:C1280_27335; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000245802; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   NCBIfam; TIGR01063; gyrA; 1.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 2.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245802};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          26..511
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          770..819
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        782..803
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   910 AA;  99289 MW;  BA3D4ECCF4C5BA3D CRC64;
     MADATTPPSG PNEPPAAGAV APINPLDIVD ELRDSYLTYA QSVIISRALP DVRDGLKPSQ
     RRILVAMNDL GLGPASSTSK CAGIIGETMK RYHPHGDASI YDSLVRMAQD WNLRYRLVHG
     QGNFGSIAGL PPAAHRYTEA RLTPAAGELL EDLERDTVDF IDNYDGKYRE PLVLPGKFPN
     LLVNGSDGIA VGMATHIPPH NLREVCKALV LLLDNPGATL ADLIQIIPGP DFPTGGIIMG
     RQGLLEAYAR GAGKITLRAR AQVMEEVKGR SPSILISEVP FQVTRNAIVE EIAHLVKEER
     IPDVSGVRDE SSARNGEPVR LIVEIKRGKD PHLVLNQLYQ YTKLQKTVSI IMLALVDGRP
     RELTLKEMLQ KFLDHRVHVI RRRTEFLLRE AKKRGHVLEG QLIAIADIEQ VIQICRTSPN
     RAEAKARLQG LAVPAALMQR AIGEGAFAAL QRELGAVAEY RMTEQQAEAV VNLRLGQLAA
     LESEEILKEY LQLRELIRGY ETLLSDDANI HAVIREDLER MAAKYGDDRK TEVSDDGGDV
     DMEDLIVDEP NVVTISHEGF VKRMALTEYR VQGRGGKGVQ GGLRDNDFVE HFFVASTKAY
     LLCFANTGRM YWLKVYRIPT AGRTSPGRAI ANVLSLAEGE KISSIVPVRE FVEGAHLLMA
     TRQGTVKKTD LMAYSNVRQG GIIGITLDEG DELINVALTR ANDEVVLSTQ KGMAIRFRES
     AIRPMGRTAR GVRGIKLGKD DALVGMVVAD PDGLLLTVCE NGYGKRTPFG ANTPLPEGAV
     EADDEAAPEP EVVEPEAPEG AEGEAEADPS GMRYRLQGRG GKGVKDVKVT AKNGKVISVT
     SVRDGDEIML ITKDGMVTRS KVGDIRIVGR NTQGVRVMNL RDGDKLVSVA KVAQENVGDA
     EAKEEDKKPQ
//