ID A0A2Z4L7N4_9EURY Unreviewed; 957 AA.
AC A0A2Z4L7N4;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=UvrABC system protein A {ECO:0000256|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000256|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000256|HAMAP-Rule:MF_00205};
GN ORFNames=AW729_04255 {ECO:0000313|EMBL:AWX32364.1};
OS Methanosphaera sp. BMS.
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanosphaera.
OX NCBI_TaxID=1789762 {ECO:0000313|EMBL:AWX32364.1, ECO:0000313|Proteomes:UP000249370};
RN [1] {ECO:0000313|Proteomes:UP000249370}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BMS {ECO:0000313|Proteomes:UP000249370};
RA O Cuiv P.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AWX32364.1, ECO:0000313|Proteomes:UP000249370}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BMS {ECO:0000313|EMBL:AWX32364.1,
RC ECO:0000313|Proteomes:UP000249370};
RA Morrison M.;
RT "Methanosphaera spp. pan-genomic study of isolate and population genomes.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000256|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|HAMAP-Rule:MF_00205}.
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DR EMBL; CP014213; AWX32364.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2Z4L7N4; -.
DR KEGG; metb:AW729_04255; -.
DR OrthoDB; 7896at2157; -.
DR Proteomes; UP000249370; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd03270; ABC_UvrA_I; 1.
DR CDD; cd03271; ABC_UvrA_II; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00205};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|HAMAP-Rule:MF_00205};
KW SOS response {ECO:0000256|ARBA:ARBA00023236, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_00205};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|HAMAP-
KW Rule:MF_00205}.
FT DOMAIN 623..952
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT ZN_FING 267..294
FT /note="C4-type"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
FT ZN_FING 755..781
FT /note="C4-type"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
FT BINDING 44..51
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
FT BINDING 655..662
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
SQ SEQUENCE 957 AA; 106822 MW; 79D7B8EC6992C7C0 CRC64;
MQSKDKLRKE AIQNKKIIVK GAREHNLQNI DLTIPRDEFI VITGLSGSGK SSLAFDTIYA
EGQRRYVESL SAYARQFLGQ MEKPEVDYIE GLSPAISIDQ KTTRVNPRST VGTVTEIYDY
LRLLYARIGI AHCYNCGKEI SQQTPGQISQ IIIDENEHQK ILVLAPVVKD RKGMHLKVFE
KLKEKGFVRV RVDGEILSLD EDIKLNKNNK HVIEVVVDRL KVANNENFRK RLVESVETAL
DIGDGLVTIA SNDADTPDQI YSEALACPDC GISFTEISPR MFSFNNPQAA CPLCNGIGST
MEADPDLVVP DKTLSIHEGA IKPWSNSTKT DTYYNRLLAG VANHYGFNLD VPYHTLSQKH
KDILLYGSGD ENITFTFETS GKIRNKTKPF EGVIPYMKRL FIETKSRYRR KATRTYMSLN
DCPMCHGDRL KPEMLAVTVG DINIADLTKL SLSDCQEFFN NLELTERQEF IGHEILKEIN
ERLSFLNDVG LNYLTLARSS GTLSGGEAQR IRLATQIGSR LVGVLYVLDE PSIGLHQKDN
MKLIETLKHL RDIGNTLIVV EHDEETILEA DHVVDIGPGA GEHGGLLIAQ GTPEEVKNNE
NSLTGQYLSG KKSIPIPKKR HEGNGKKITV IGASENNLKN INVDFPLGEF ICVTGVSGSG
KSTLVNEILY HGIDEILTHK HKHKVGKHKS IKGVENIDKI IVIDQSPIGR TPRSNPATYI
GLFTHIRELF AQTPESKQRG YKPGRFSFNV KGGRCEACSG DGIVQIEMHF LADVYVPCEV
CDGKRYNHET LDVRYKGKNI NDVLEMTCDE ALEFFEHLPK IKRKLQTLVD VGLGYIKLGQ
PATTLSGGEA QRVKLAKELS RQNTSNTLYI LDEPTTGLHF EDINKLLKVL CKLRNQGNTL
IVIEHNLDVI KTADYIIDLG PDGGKYGGEL IASGTPEEII KTDTYTAQYL RSTLEKE
//
