ID   A0A2Z4LQJ8_9FLAO        Unreviewed;       430 AA.
AC   A0A2Z4LQJ8;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000256|ARBA:ARBA00012338, ECO:0000256|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000256|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000256|ARBA:ARBA00012338, ECO:0000256|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000256|HAMAP-Rule:MF_00006};
GN   Name=argH {ECO:0000256|HAMAP-Rule:MF_00006,
GN   ECO:0000313|EMBL:AWX44042.1};
GN   ORFNames=HME9304_01042 {ECO:0000313|EMBL:AWX44042.1};
OS   Allomuricauda aurantiaca.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Allomuricauda.
OX   NCBI_TaxID=1383885 {ECO:0000313|EMBL:AWX44042.1, ECO:0000313|Proteomes:UP000248536};
RN   [1] {ECO:0000313|EMBL:AWX44042.1, ECO:0000313|Proteomes:UP000248536}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HME9304 {ECO:0000313|EMBL:AWX44042.1,
RC   ECO:0000313|Proteomes:UP000248536};
RA   Kang H., Kim H., Joh K.;
RT   "Spongiibacterium sp. HME9304 Genome sequencing and assembly.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000985, ECO:0000256|HAMAP-
CC         Rule:MF_00006};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 3/3.
CC       {ECO:0000256|ARBA:ARBA00004941, ECO:0000256|HAMAP-Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_00006}.
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DR   EMBL; CP030104; AWX44042.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2Z4LQJ8; -.
DR   KEGG; spon:HME9304_01042; -.
DR   OrthoDB; 9769623at2; -.
DR   UniPathway; UPA00068; UER00114.
DR   Proteomes; UP000248536; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR   Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR   Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   NCBIfam; TIGR00838; argH; 1.
DR   PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR   PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00145; ARGSUCLYASE.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; L-aspartase-like; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00006};
KW   Arginine biosynthesis {ECO:0000256|ARBA:ARBA00022571, ECO:0000256|HAMAP-
KW   Rule:MF_00006}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00006};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00006, ECO:0000313|EMBL:AWX44042.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248536}.
FT   DOMAIN          26..300
FT                   /note="Fumarate lyase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00206"
SQ   SEQUENCE   430 AA;  48311 MW;  F7F4C8FF307D01B8 CRC64;
     MKLWDKGFST DQKIDHFTVG NDRELDLLLA KYDVIASKAH AKMLGDVGLI TKDESEDLVR
     ELDSIAKTID GGTFTIEDSF EDMHSKIEFL LIEKLGNTGK KIHTARSRND QVLVAMQLYL
     KNELTEIKSE VRILFDLLLD LAETHRSTLL PGYTHLQIAM PSSFGLWFSA YAESLIDDLY
     FVNAAYKIAD QNPLGSAAGY GSSFPVDRTS TTKEMGFTTM KYNVVAAQMG RGKVEKAAAF
     GISSIASTLS KLAMDICLYM SQNFDFITFP DELTTGSSIM PHKKNPDVFE LIRAKCNKIQ
     AVPNQLVLIT NNLPSGYHRD LQLVKEVIVP AIQDIKACLE LMHFSLKEIK VNDKILEDPK
     YNYLFSVDTL NELVKNGMPF RDAYKKMGAE IEAGTFQPKK DIHHTHEGSL GNLCLEEIRE
     KMKGITDHYI
//