ID A0A2Z4LV70_9FLAO Unreviewed; 788 AA.
AC A0A2Z4LV70;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Tyrosine-protein kinase CpsD {ECO:0000313|EMBL:AWX45815.1};
DE EC=2.7.10.- {ECO:0000313|EMBL:AWX45815.1};
GN ORFNames=HME9304_02845 {ECO:0000313|EMBL:AWX45815.1};
OS Allomuricauda aurantiaca.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Allomuricauda.
OX NCBI_TaxID=1383885 {ECO:0000313|EMBL:AWX45815.1, ECO:0000313|Proteomes:UP000248536};
RN [1] {ECO:0000313|EMBL:AWX45815.1, ECO:0000313|Proteomes:UP000248536}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HME9304 {ECO:0000313|EMBL:AWX45815.1,
RC ECO:0000313|Proteomes:UP000248536};
RA Kang H., Kim H., Joh K.;
RT "Spongiibacterium sp. HME9304 Genome sequencing and assembly.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; CP030104; AWX45815.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2Z4LV70; -.
DR KEGG; spon:HME9304_02845; -.
DR OrthoDB; 9794577at2; -.
DR Proteomes; UP000248536; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AWX45815.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248536};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AWX45815.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..100
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 435..505
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 580..720
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 788 AA; 88356 MW; B8D0C076DE4DFF06 CRC64;
MENNSSKGID LKSLLSNYTK QWKWFILSLF ITLGIAFMII RYSTPQYSAQ AKVQILDSQS
STPELSVFQD LDVFAGSSNP VEDEIQTVKS RSNFIEIVKS LKLNVKIVLL GNLLDSEIYG
VTPFNLNFIE PDSVIHNSNA QFYITINSEN SLSFSDSEEG PDRAFSFGKK INTKLGGLVI
TPNLERIDDY IGRKFRISIT PIHYVAQDYL KRINIFPAEN ASTIIDITLQ DNIQQKAQDI
INSLIFLYNQ NAVEDKRTIA NRTSDFINNR ITDISSSLSN VDQSAEDFKT DRGLTDIASE
SNINLTVGAT NQQELQNTNT QLNIASSMKD IVDNQQGYEV LPSNIGLSDP TIGNISAKYN
ELVLERKRLL KSSNEKNPII VNLDEQLDGL KRNMQSSLSS MTNNLGLQLN NLNVRRSQIN
SRIYSAPGNE RALRDITRKQ QTTEQLYLYL LQKREESQIA FASAAPKSRV IDSAYSESSA
PVSPEKSIIY SVAFLVGLFV PFVVIYAGEL LDDKVHNKLD VEKLVGDVPV LAELPKLSKK
ENKLIYNKDR SVLAESLRIL RTNLDYIIAS NKKIDKKNLI FVTSSISGEG KTFLSSNLSM
VLASTNKKVL LIGADIRNPK LYKFFSGVES DAINKPRRIK EVGLTEYLIN DELTSKDVIT
PMLVHENTID IIYSGKIPPN PAELLMSDRV GKLLDEVSKI YDYVIVDTAP LMVVTDTLLI
SEHASQIIYV TKAGVTENRV LEFPLKLKNE GKLNNLSFVV NNVKASDLGY GGKYGYGYSK
QLKKWWKF
//
