ID   A0A2Z4UYN0_9ACTN        Unreviewed;       343 AA.
AC   A0A2Z4UYN0;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=HAD-IB family hydrolase {ECO:0000313|EMBL:AWZ13957.1};
GN   ORFNames=DRB96_18545 {ECO:0000313|EMBL:AWZ13957.1};
OS   Streptomyces sp. ICC1.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2099583 {ECO:0000313|EMBL:AWZ13957.1, ECO:0000313|Proteomes:UP000250268};
RN   [1] {ECO:0000313|EMBL:AWZ13957.1, ECO:0000313|Proteomes:UP000250268}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ICC1 {ECO:0000313|EMBL:AWZ13957.1,
RC   ECO:0000313|Proteomes:UP000250268};
RA   Gosse J.;
RT   "Whole genome sequencing and metabolomic study of cave Streptomyces
RT   isolates ICC1 and ICC4.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. SerB family.
CC       {ECO:0000256|ARBA:ARBA00009184}.
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DR   EMBL; CP030287; AWZ13957.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2Z4UYN0; -.
DR   Proteomes; UP000250268; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd02612; HAD_PGPPase; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   Gene3D; 1.20.1440.100; SG protein - dephosphorylation function; 1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006385; HAD_hydro_SerB1.
DR   InterPro; IPR023214; HAD_sf.
DR   NCBIfam; TIGR01488; HAD-SF-IB; 1.
DR   NCBIfam; TIGR01490; HAD-SF-IB-hyp1; 1.
DR   PANTHER; PTHR43344; PHOSPHOSERINE PHOSPHATASE; 1.
DR   PANTHER; PTHR43344:SF13; PHOSPHOSERINE PHOSPHATASE SERB1; 1.
DR   Pfam; PF12710; HAD; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:AWZ13957.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000250268};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        317..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          56..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   343 AA;  36628 MW;  EE27678029654406 CRC64;
     MAALGWLTPR RRSATARSVL AGEASAEAAR KTALADEPLD TVDSAEALEA AEAEEAEALE
     ARDAAAAEAT APTAPAEPAE PEFPVAGDDL AAAFFDLDNT VMQGAAIFHF GRGLYKREFF
     QRRELARFAW QQAWFRLAGV EDPEHMQDAR DSALSIVKGH KVSELMSIGE EIYDEYMAER
     IWPGTRALAQ AHLDAGQKVW LVTAAPVETA TIIARRLGLT GALGTVAESV DGVYTGRLVG
     EPLHGPAKAE AVRALASAEG LDLARCAAYS DSHNDIPMLS LVGHPYAINP DTKLRKHARA
     HDWRLRDYRT GRKAVKVGVP AAAGVGAIAG GAAAAIALHR RRK
//