ID A0A2Z4UZW9_9ACTN Unreviewed; 555 AA.
AC A0A2Z4UZW9;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=DRB96_18570 {ECO:0000313|EMBL:AWZ13962.1};
OS Streptomyces sp. ICC1.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2099583 {ECO:0000313|EMBL:AWZ13962.1, ECO:0000313|Proteomes:UP000250268};
RN [1] {ECO:0000313|EMBL:AWZ13962.1, ECO:0000313|Proteomes:UP000250268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICC1 {ECO:0000313|EMBL:AWZ13962.1,
RC ECO:0000313|Proteomes:UP000250268};
RA Gosse J.;
RT "Whole genome sequencing and metabolomic study of cave Streptomyces
RT isolates ICC1 and ICC4.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
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DR EMBL; CP030287; AWZ13962.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2Z4UZW9; -.
DR Proteomes; UP000250268; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AWZ13962.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000250268};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AWZ13962.1}.
FT DOMAIN 20..229
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 288..518
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 531..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..545
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 58240 MW; B190EBBAD7B02B82 CRC64;
MNPTSPTTSA FPAVAVHGHV TFLGAGPGDP GLLTLRAVEA LAAADVLIAE PEVLEVVRTH
ARAGVDTPQL TIADEKSAAA GVPVIRDAAN LVMEAARSGR RVVRAVTGDP GLDGHAADEM
LACATEGIPF EVVPGVATAV GVPAYAGVPL SGKQGADVRF VNARSASQRC WSEAGASDGI
LVVSATLETV SAAAAELVSA GRKPDTPLTV TVAGTTTRQR TWSATLGTIA QVFKQGKILP
SPEGSRPVIA VVGEHGAAAR REELSWFESK PLFGWRVLVP RTKEQAASLS DQLRSYGAVP
HEVPTIAVEP PRTPQQMERA VKGLVTGRYE WIAFTSVNAV KAVREKFEEY GLDARAFAGI
KVAAVGEQTA AALVEFGVKP DLVPSGEQSA AGLLEDWPPY DPVFDPIDRV FLPRADIATE
TLVAGLIELG WEVDDVTAYR TVRASPPPQD TREAIKGGGF DAVLFTSSST VRNLVGIAGK
PHNVTVIACI GPATAKTAEE HGLRVDVLSP EPSVGKLAEA LAEYGAARRE AAKEAGENVY
RPSERRPGAR RRRTT
//
