ID   A0A2Z4V2Q6_9ACTN        Unreviewed;       359 AA.
AC   A0A2Z4V2Q6;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=MBL fold metallo-hydrolase {ECO:0000313|EMBL:AWZ15543.1};
GN   ORFNames=DRB96_28460 {ECO:0000313|EMBL:AWZ15543.1};
OS   Streptomyces sp. ICC1.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2099583 {ECO:0000313|EMBL:AWZ15543.1, ECO:0000313|Proteomes:UP000250268};
RN   [1] {ECO:0000313|EMBL:AWZ15543.1, ECO:0000313|Proteomes:UP000250268}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ICC1 {ECO:0000313|EMBL:AWZ15543.1,
RC   ECO:0000313|Proteomes:UP000250268};
RA   Gosse J.;
RT   "Whole genome sequencing and metabolomic study of cave Streptomyces
RT   isolates ICC1 and ICC4.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP030287; AWZ15543.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2Z4V2Q6; -.
DR   Proteomes; UP000250268; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23131; ENDORIBONUCLEASE LACTB2; 1.
DR   PANTHER; PTHR23131:SF0; ENDORIBONUCLEASE LACTB2; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AWZ15543.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000250268}.
FT   DOMAIN          39..269
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   359 AA;  38999 MW;  93D88B14BB885F55 CRC64;
     MAEDTAQADA PRVDGPHVTD HGGGVWAVKV PIPDNPLGHT LVHVLDTDRG PVLIDTGWDD
     PESWDTLVAG LGALSIAVAD VHGVVITHHH PDHHGLSGQV REASGAWIAM HAADTEIVVR
     TRSSEPGVWF DYMSEKLATA GAPEEHIAPL RAARASGRTH TLPGLSAAVP DREIVPGELL
     PLAGRRLRAI WTPGHTPGHV CLHLEEKHPA NLPGNGRLFS GDHLLPGISP HIGLYEDPSS
     ERATDPLGDY LDSLERIGRL QPAEVLPAHQ YAFTDAQGRV RELLDHHEDR LTGLWELLAE
     PLTPWGLAER MEWNRPWEQI PYGSRNIAVS EAEAHLRRLV KQGRAEAVPG SAPVSYRAL
//