ID   A0A2Z4VAZ6_9ACTN        Unreviewed;       321 AA.
AC   A0A2Z4VAZ6;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=SAM-dependent methyltransferase {ECO:0000313|EMBL:AWZ18247.1};
GN   ORFNames=DRB96_26210 {ECO:0000313|EMBL:AWZ18247.1};
OS   Streptomyces sp. ICC1.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2099583 {ECO:0000313|EMBL:AWZ18247.1, ECO:0000313|Proteomes:UP000250268};
RN   [1] {ECO:0000313|EMBL:AWZ18247.1, ECO:0000313|Proteomes:UP000250268}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ICC1 {ECO:0000313|EMBL:AWZ18247.1,
RC   ECO:0000313|Proteomes:UP000250268};
RA   Gosse J.;
RT   "Whole genome sequencing and metabolomic study of cave Streptomyces
RT   isolates ICC1 and ICC4.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP030287; AWZ18247.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2Z4VAZ6; -.
DR   Proteomes; UP000250268; Chromosome.
DR   GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR016461; COMT-like.
DR   InterPro; IPR001077; O_MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR   PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR   Pfam; PF00891; Methyltransf_2; 1.
DR   PIRSF; PIRSF005739; O-mtase; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51683; SAM_OMT_II; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:AWZ18247.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000250268};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000313|EMBL:AWZ18247.1}.
FT   DOMAIN          100..302
FT                   /note="O-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00891"
FT   ACT_SITE        231
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ   SEQUENCE   321 AA;  34724 MW;  F1ED34477D744E62 CRC64;
     MYGYIHSAAL RAVAVHRIAD HLAEGPRTAE ELAARTGTHG PSLHRVLRLL AIRGLFREDE
     RGGFRLTEDG QGLRTDLPGS QHSSVLMITD PMFRRSADGL EDTLVTGRPG FTEAYGATFF
     EYLGKSPEDR ATFDTGMATF SGPVDELVAQ GYDFPADSRV VDVAGGRGGL LRAFLARNPT
     LTGVLFDQPA TVAEHVLDSP GLANRWETEG GDFFAGVPAG GDFYVLKHIL HDWNDEDALR
     ILGSVRRAAS AGTRLLVVDT VLPEASAPHP GVELDIVMLM VLRGRERTAR EFDDLLARAG
     FRVDRVLPTP ALPSIVEAVA V
//