ID A0A2Z4VCV8_9ACTN Unreviewed; 547 AA.
AC A0A2Z4VCV8;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=DRB96_33445 {ECO:0000313|EMBL:AWZ18410.1};
OS Streptomyces sp. ICC1.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2099583 {ECO:0000313|EMBL:AWZ18410.1, ECO:0000313|Proteomes:UP000250268};
RN [1] {ECO:0000313|EMBL:AWZ18410.1, ECO:0000313|Proteomes:UP000250268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICC1 {ECO:0000313|EMBL:AWZ18410.1,
RC ECO:0000313|Proteomes:UP000250268};
RA Gosse J.;
RT "Whole genome sequencing and metabolomic study of cave Streptomyces
RT isolates ICC1 and ICC4.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; CP030287; AWZ18410.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2Z4VCV8; -.
DR Proteomes; UP000250268; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:AWZ18410.1};
KW Helicase {ECO:0000313|EMBL:AWZ18410.1};
KW Hydrolase {ECO:0000313|EMBL:AWZ18410.1};
KW Nucleotide-binding {ECO:0000313|EMBL:AWZ18410.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000250268}.
FT DOMAIN 189..343
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 397..547
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 547 AA; 60721 MW; F477A85CE4898F83 CRC64;
MNGPLIVQSD KTLLLEIDHE LSGAARRAIA PFAELERAPE HIHTYRITPL GLWNARAAGH
DAEQVVDALV EFSRYPVPHA LLVDVAETMA RYGRLTLSKH PVHGLVLTST DRPVLEEILR
SKRIAPLVGA RLDADTVAVH PSERGQIKQT LLKLGWPAED LAGYVDGEAH PIELDENGWS
LRPYQQQAVE GFWHGGSGVV VLPCGAGKTL VGAGAMAKAK ATTLILVTNT VSARQWKSEL
IKRTSLTEEE IGEYSGTRKE IRPVTIATYQ VLTTKRKGIY PHLELFDSRD WGLILYDEVH
LLPAPVFKFT ADLQARRRLG LTATLVREDG RESDVFSLIG PKRFDAPWKE IEAQGYIAPA
DCVEVRVNLT EAERLAYATA ETEEKYRFCA TTATKRKVTE ALVRKHAGEQ TLVIGQYIDQ
LDELGEHLNA PVIKGETSNA QREKLFNAFR EGEISVLVVS KVANFSIDLP EATVAIQVSG
TFGSRQEEAQ RLGRVLRPKA DGHEARFYSV VARDTIDQDF AAHRQRFLAE QGYAYRIMDA
DELLASD
//
