ID A0A2Z4WEM6_9CLOT Unreviewed; 630 AA.
AC A0A2Z4WEM6;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN Name=lonC {ECO:0000313|EMBL:AWZ49731.1};
GN ORFNames=C3495_13460 {ECO:0000313|EMBL:AWZ49731.1};
OS Clostridiaceae bacterium 14S0207.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae.
OX NCBI_TaxID=2082193 {ECO:0000313|EMBL:AWZ49731.1, ECO:0000313|Proteomes:UP000250207};
RN [1] {ECO:0000313|EMBL:AWZ49731.1, ECO:0000313|Proteomes:UP000250207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=14S0207 {ECO:0000313|EMBL:AWZ49731.1,
RC ECO:0000313|Proteomes:UP000250207};
RA Thomas P., Seyboldt C.;
RT "Complete genome sequence of Clostridium limosum strain from Germany.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
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DR EMBL; CP026600; AWZ49731.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2Z4WEM6; -.
DR OrthoDB; 2318150at2; -.
DR Proteomes; UP000250207; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008268; Peptidase_S16_AS.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR002078; Sigma_54_int.
DR InterPro; IPR014252; Spore_LonC.
DR NCBIfam; TIGR02903; spore_lon_C; 1.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR10046:SF64; LON PROTEASE; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF05362; Lon_C; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
DR PROSITE; PS01046; LON_SER; 1.
DR PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000250207};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01122}.
FT DOMAIN 179..351
FT /note="Sigma-54 factor interaction"
FT /evidence="ECO:0000259|PROSITE:PS50045"
FT DOMAIN 459..630
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT ACT_SITE 542
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 585
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 630 AA; 70187 MW; 7B42855C1D86D364 CRC64;
MSRNKIKNFA ESIEKQDLSL DVQLELLYHI ANKILTEGGV QSRIVKFSLR KHIESNDIFK
KAYALNKIIS NGKCSNSIPN EKNIERYLDK INDSLVDEVA KRYVNNKLEA EVEQAIVEKQ
DKYVDEVKLG IIRKRKGPEN AKTIKKYEEL VNLDKKQLIN NIQSKLRPQS FKEIVGQERA
IKALLSKIAS PYPQHIILYG PPGVGKTTAA RIALEEAKKL AYTPYDGDSK FVEVDGTTLR
WDPREITNPL LGSVHDPIYQ GSKREFSEIG VPEPKPGLVT EAHSGILFID EIGELDTILQ
NKLLKVLEDK RVEFSSSYYD PDDENVPKYV KYLFEHGAPA DFVLIGATTR EPKEINPALR
SRCTEVYFEP LTNIDIEKIV INAAEKINVE LEEGVARAIS NYTIEGRKAV NILSDVYAYV
LHDKGLNPKE TIKITMEDLD QVISISRLNA LDKVLDKDKK EIGHIYGLGV LGYIGSTLEI
EAVAFETENG KGTVRFNDTA GSMAKDSVFN AATVIRKITN KDIKDYDIHV NVVGGAKIDG
PSAGAAITTC IISAILGKPI RQDVAITGEI SLRGNVKPVG GIFEKIYGAR RKGINLVIVP
KDNEKEVPMG LNDIEVKSVG NIEEIMNIVF
//