ID A0A2Z5EC75_9SPHN Unreviewed; 774 AA.
AC A0A2Z5EC75;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase family protein {ECO:0000313|EMBL:AXB77271.1};
GN ORFNames=TQ38_012860 {ECO:0000313|EMBL:AXB77271.1};
OS Novosphingobium sp. P6W.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1609758 {ECO:0000313|EMBL:AXB77271.1, ECO:0000313|Proteomes:UP000032296};
RN [1] {ECO:0000313|EMBL:AXB77271.1, ECO:0000313|Proteomes:UP000032296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P6W {ECO:0000313|EMBL:AXB77271.1,
RC ECO:0000313|Proteomes:UP000032296};
RA Nikolaichik Y.A., Safronova V.I., Belimov A., Gogolev Y.V., Gogoleva N.E.;
RT "Complete genome sequence of Novosphingobium sp. P6W.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; CP030352; AXB77271.1; -; Genomic_DNA.
DR RefSeq; WP_043970931.1; NZ_CP030352.1.
DR AlphaFoldDB; A0A2Z5EC75; -.
DR STRING; 1609758.TQ38_02775; -.
DR KEGG; nov:TQ38_012860; -.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000032296; Chromosome 1.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 7..191
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 193..294
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 349..401
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 774 AA; 82659 MW; E10BAA6D780AABE1 CRC64;
MSDTIRKVCV IGAGTMGAGI AAQVANAGVP VLLLDIVPKD AGNRNAIAEG AVAKMLKTEP
APFMSKSAAK LVETGNIEDH LEKIAECDWV IEAVIERLDI KQGLYAKIEA VKRDGTAVSS
NTSTIPLGQL VEGRSAAFQR DFLITHFFNP PRYMRLLEIV TGPATDTAIA AKVEHFSDAA
LGKTVVRAND TPGFIANRIG TYWIQLGLNA AFDMGLTVEL ADAIAGKPMG VPKTGIFGLV
DLVGIDLMPH LQASLTSTLP KDDPYHAIAR TMPLIEKMIG EGYTGRKGKG GFYRLNKEMG
RRKETIDLAS GEYRETIRAF GPSGAAGKGD LRALVETKGK IGDYAWAVLG GTLAYAAALV
PSAAGDVVAI DDAMKLGYNW KAGPFEMIDK LGADWLAQRL ESEGKPVPEI LKIAGDRTFY
RVEDGKRQYL DLDGTYHDIR RPEGVLKLSD IKLASKPLLK NGSAALWDVG DGVVALEFTG
KMNALDGDVM KLIVEAIPLV KAKYKALVVY NDADSFSAGA NLGLALFAVN IAAWGEIEKL
IAGGQMAYKG LKYAPFPVVG APAGLAVGGG CEILLHCDAV QAHAELYMGL VECGVGLIPG
WGGNGEMLDR WQKNRGMPKG PMPAVAKVFE TVSTASVSRS AAQAKELLFL RADDGVTMNR
DRLLYDAKQK ALSLVEGYTA PEAPTFRLPG ESGRTALGMA AEGFHKQGKA TDYDMVVSAA
LAGVLSGGEA DLVDTVSEAE LLKLERETFM RLVREPRSIA RVEHMLETGK PLRN
//
