ID A0A2Z5EKQ8_9SPHN Unreviewed; 474 AA.
AC A0A2Z5EKQ8;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE SubName: Full=NAD-dependent epimerase/dehydratase family protein {ECO:0000313|EMBL:AXB80247.1};
GN ORFNames=TQ38_027055 {ECO:0000313|EMBL:AXB80247.1};
OS Novosphingobium sp. P6W.
OG Plasmid pp6w1 {ECO:0000313|Proteomes:UP000032296}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1609758 {ECO:0000313|EMBL:AXB80247.1, ECO:0000313|Proteomes:UP000032296};
RN [1] {ECO:0000313|EMBL:AXB80247.1, ECO:0000313|Proteomes:UP000032296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P6W {ECO:0000313|EMBL:AXB80247.1,
RC ECO:0000313|Proteomes:UP000032296};
RC PLASMID=Plasmid pp6w1 {ECO:0000313|Proteomes:UP000032296};
RA Nikolaichik Y.A., Safronova V.I., Belimov A., Gogolev Y.V., Gogoleva N.E.;
RT "Complete genome sequence of Novosphingobium sp. P6W.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637}.
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DR EMBL; CP030354; AXB80247.1; -; Genomic_DNA.
DR RefSeq; WP_043975955.1; NZ_CP030354.1.
DR AlphaFoldDB; A0A2Z5EKQ8; -.
DR STRING; 1609758.TQ38_15820; -.
DR KEGG; nov:TQ38_027055; -.
DR OrthoDB; 9772736at2; -.
DR Proteomes; UP000032296; Plasmid pp6w1.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42687; L-THREONINE 3-DEHYDROGENASE; 1.
DR PANTHER; PTHR42687:SF1; L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Plasmid {ECO:0000313|EMBL:AXB80247.1}.
FT DOMAIN 10..172
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 474 AA; 53574 MW; 81BD8542D6BE3E4C CRC64;
MTDSRKTIFL TGATGNMGRE AVRRISANND IWKLRILVRP EEKGHAVVRE VIRHDLAEIS
WGDLTDAQSV RAGVKGADIV LHVGGLVSPL ADRLPEEVVT RVNVGGARNI VDAIHAVGDP
SRTRLVYIGT VAQTGSRNAP IHWGRAGDPI KISAYDHYAV TKTKAEAIIA ESGILHWVSL
RQSGMAHYEM WKIFDPIMFH NPLNGVFEWS TANDSGRLMA GVCDDNVPAE FWRGFYNIGG
GESSRMINHK FMAATSPDFR QILRPHWFAT RNFHGQWYSD SDRLQALVPF REQPLSDWLV
ETRRRTPWLV RNIPAWLPRL ARGRIEALAK APEGSLHWFE HGEEAKIAAY FGSRAAWEAI
PRDWDDFVFE EPSRTPHLIN HGYDEGRAPE EWTLEDLRSA AEFRGGKCLS TEFEGADVPV
EWRSASGNRF SMTPRLYLKG GHWCPDAMLQ PKNYAQEAER NPFFAQVWTQ EAES
//
