ID A0A2Z5QX63_9MICC Unreviewed; 856 AA.
AC A0A2Z5QX63;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=ATP-dependent Clp protease ClpC {ECO:0000313|EMBL:BAV87018.1};
DE SubName: Full=Probable ATP-dependent Clp protease ATP-binding subunit {ECO:0000313|EMBL:VEI22137.1};
GN Name=clpC {ECO:0000313|EMBL:VEI22137.1};
GN ORFNames=NCTC10207_00203 {ECO:0000313|EMBL:VEI22137.1}, RA11412_0719
GN {ECO:0000313|EMBL:BAV87018.1};
OS Rothia aeria.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Rothia.
OX NCBI_TaxID=172042 {ECO:0000313|EMBL:BAV87018.1, ECO:0000313|Proteomes:UP000250241};
RN [1] {ECO:0000313|EMBL:BAV87018.1, ECO:0000313|Proteomes:UP000250241}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 11412 {ECO:0000313|EMBL:BAV87018.1,
RC ECO:0000313|Proteomes:UP000250241};
RA Nambu T.;
RT "Genome sequence of Rothia aeria strain JCM11412.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:VEI22137.1, ECO:0000313|Proteomes:UP000282386}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC10207 {ECO:0000313|EMBL:VEI22137.1,
RC ECO:0000313|Proteomes:UP000282386};
RG Pathogen Informatics;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|RuleBase:RU004432}.
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DR EMBL; AP017895; BAV87018.1; -; Genomic_DNA.
DR EMBL; LR134479; VEI22137.1; -; Genomic_DNA.
DR RefSeq; WP_006888502.1; NZ_LR134479.1.
DR AlphaFoldDB; A0A2Z5QX63; -.
DR GeneID; 78535844; -.
DR KEGG; raj:RA11412_0719; -.
DR Proteomes; UP000250241; Chromosome.
DR Proteomes; UP000282386; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:BAV87018.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:BAV87018.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000250241};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 2..144
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT DOMAIN 427..462
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT REGION 832..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 423..469
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 856 AA; 94681 MW; B59F9698076E2F22 CRC64;
MFERFTDRAR RVVVLAQEEA RMLNHNYIGT EHLLLGLVHE GEGIAARALE SLGITLNSVR
EQVQDIIGPG ANAPSGHIPF TPRAKKVLEL SMREAIQLNH GYIGTEHILL GMVRANEGVA
NQVLAKLGVE PAAVRQAVMD LISGYPGNGD SKETAGVGAG NSREGTPAGS TILDQFGRNL
TAAAREGQLD PVIGRHHEME RVMQVLSRRT KNNPVLIGEP GVGKTAVVEG LAQAIVHGDV
PETLKDKHLY TLDLGSLVAG SRYRGDFEER LKKVLKEIRT RGDIILFIDE IHTLVGAGAA
EGAIDAASIL KPMLARGELQ TIGATTLDEY RKHIEKDAAL ERRFQPIQVD EPSQELAVQI
LKGVRDKYEA HHRVTISDEA IETAVNLAAR YISDRFLPDK AVDLIDEAGA RLRIKRMTAP
PEIKVLEEKA GKLKRAKEDA IREQDYEKAA GLRDEEQKVL QEKDQKEKAW RENGDAFGEV
TPEVISEVLA SSTGVPVYKI TEEESSRLLK MEDELHKRVI GQEHAIKALA RSIRRTRAGL
KDPNRPGGSF IFAGPTGVGK TELAKALAEF LFGDQDALIT LDMSEYQEKH TVSRLFGAPP
GYVGYEEGGQ LTEKVRRKPF SVVLFDEVEK AHADLFNSLL QILEDGRLTD SQGRVVDFKN
TVIIMTTNLG SRDVNRRVPV GFQAMDDNAA DYERMQARVM ENLKEHFRPE FLNRVDDIIV
FPQLSETEIL QIVDLFVGRL AKRLADQDMS IELTNAAKVL MASKGYDPAM GARPLRREMQ
RNIEDALSEK ILFGEIKPGE KITVDAEGEG DDAKFTFSSQ PMKELSSEYL KDLDSQSVAE
EEAVEEAEQI TNNAAE
//
