ID   A0A2Z6DWZ4_HYDTE        Unreviewed;      1020 AA.
AC   A0A2Z6DWZ4;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=AcrB/AcrD/AcrF family protein {ECO:0000313|EMBL:BBD76996.1};
GN   ORFNames=HPTL_0728 {ECO:0000313|EMBL:BBD76996.1};
OS   Hydrogenophilus thermoluteolus (Pseudomonas hydrogenothermophila).
OC   Bacteria; Pseudomonadota; Hydrogenophilia; Hydrogenophilales;
OC   Hydrogenophilaceae; Hydrogenophilus.
OX   NCBI_TaxID=297 {ECO:0000313|EMBL:BBD76996.1, ECO:0000313|Proteomes:UP000262004};
RN   [1] {ECO:0000313|EMBL:BBD76996.1, ECO:0000313|Proteomes:UP000262004}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TH-1 {ECO:0000313|EMBL:BBD76996.1,
RC   ECO:0000313|Proteomes:UP000262004};
RA   Arai H.;
RT   "Complete genome sequence of Hydrogenophilus thermoluteolus TH-1.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AP018558; BBD76996.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2Z6DWZ4; -.
DR   KEGG; htl:HPTL_0728; -.
DR   OrthoDB; 9757940at2; -.
DR   Proteomes; UP000262004; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF18; CATION EFFLUX SYSTEM PROTEIN; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000262004};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        342..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        392..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        435..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        466..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        529..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        887..906
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        912..931
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        962..978
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        984..1011
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1020 AA;  111562 MW;  4D98135AFA190E31 CRC64;
     MAFPNLSSLA VRERAVTLFF LILALAGGAF AFLQLGRAED PAFTVRVLMV SAVWPGASAE
     AVEAQITKRL EKRLQEVPNL YRLDATVRPG RTDIKVEFHD YVPERELPQL FYEVRKRMWD
     ETRSMPAGAI GPIVNDDFSD VYFALLALTG PTKTHRELVE IGEEIRDRLQ RLPGVHKAQL
     LGERPQTVYL EFDWPRLQRL GVSPLQVMQA IQAYNEMAPA GFVETDAARL YVRLPAADLA
     ELDRLEALPL RIGSRVVPLG EVARVHLQEE DPPSYLVRSR GDDALLLGVV MQRGENGLAL
     GKRLESFLAD AQKRLPAGVH LEVLTNQAEA ISAAVDRFQV KFFMAVAVVT VVTLLALGWR
     AGVVTAIAIP LTLSIVFLIM LARGISLDRV SLGALILALG LLVDDAIIVI EMMVVKLEEG
     WDRAHAATHA WHATAAPMLF GTLVTAAGFL PIGFAKSGVG EYAGNIFWVL AYALVVSWFV
     AVLFTPYLGF KLLPHYRKIE GGIDAIYGTP AYQRLRWLIS ACVRYRKSVV AVTLALLVAA
     GVGMAKAVPK QFFPSSDRPE VLIDIQMPAG TSIATTDALT RRIEAMLAPM PEVKSMMAHV
     GRGAPRFFIS ASPEPPDTAF AKIVAVTHDV AARERVIAAV QQAVDRGEFA EGRVRVHRLL
     YGPPVAWPIE FRVMGPDLNE VRRIAHEVRA VMAQHTNVVD PHLNYDERTP VLQLTFLPER
     LASYGLTPLE VKQQLQFALT GVPVTELRRG DRTVALIARG ADAWLRDPAA LATVEVRNAA
     GARIPLQSVA KIVVAYEDQV IKRYNRERYI AVQSEVEGAQ PPDVTKALWQ ALEPLRATLP
     PGYHLEVGGT VEASGKADAS IQKLQPIMVA VTLIFIMLQM REFAGTFMTV ATAPLGLIGA
     TVALLLTQRP FGFVALLGLI GLGGILMRNT LILTQQVRDF QEQGWSPAEA VIEAAVRRAR
     PVVLTALAAA LAFLPLATDT FWGPLAIVLI GGVVVGTAIT LLFVPALYAI WYRLPKTVGV
//