ID A0A2Z6DY94_HYDTE Unreviewed; 792 AA.
AC A0A2Z6DY94;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN ORFNames=HPTL_1230 {ECO:0000313|EMBL:BBD77494.1};
OS Hydrogenophilus thermoluteolus (Pseudomonas hydrogenothermophila).
OC Bacteria; Pseudomonadota; Hydrogenophilia; Hydrogenophilales;
OC Hydrogenophilaceae; Hydrogenophilus.
OX NCBI_TaxID=297 {ECO:0000313|EMBL:BBD77494.1, ECO:0000313|Proteomes:UP000262004};
RN [1] {ECO:0000313|EMBL:BBD77494.1, ECO:0000313|Proteomes:UP000262004}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TH-1 {ECO:0000313|EMBL:BBD77494.1,
RC ECO:0000313|Proteomes:UP000262004};
RA Arai H.;
RT "Complete genome sequence of Hydrogenophilus thermoluteolus TH-1.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
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DR EMBL; AP018558; BBD77494.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2Z6DY94; -.
DR KEGG; htl:HPTL_1230; -.
DR OrthoDB; 9758568at2; -.
DR Proteomes; UP000262004; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041699; AAA_32.
DR InterPro; IPR046844; Lon-like_helical.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR046843; LonB_AAA-LID.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046:SF46; ARCHAEAL LON PROTEASE; 1.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR Pfam; PF13654; AAA_32; 1.
DR Pfam; PF05362; Lon_C; 1.
DR Pfam; PF20436; LonB_AAA-LID; 1.
DR Pfam; PF20437; LonC_helical; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000262004};
KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01122}.
FT DOMAIN 557..753
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 648
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 691
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 792 AA; 86810 MW; 76EF3F3551A2EC28 CRC64;
MTQIATLDPQ SLYRRTQLDT QPVPDSTHRP PFVGQDAALE TLALALADAR RGHVVLMAPP
GYGRHAIARW TAEQAARKRL SPHDLLYVPR FDDPLRPQLL RLPAGKGREL AAAVERLVQR
LPELVRGALT ADPHRTRIEA LLKRHQERQQ QALAEIRDGC AGDRLKLLQT DDGWALVPTD
EHGEPFTPEA YAALPETERK RWEERVARWR DRLAAVLARF PEWDEALADA IDAAERDALA
PVARHLLHPL REAFADFSEV LAYLDAFEAE LVRGPRPWLA RDGTEVLIDE AVLAHYLVNP
SVVHEAQAHA PVCLGENISH ATLVGWVESE VVEDERISDH RHIRAGHLAQ AADGFLLVDA
TALLADSDAW QALKRTLATQ RVEVAPPPAQ TRWGALPLVR PDPIPFAGQV ILIVTPEIYE
ALRDLDETFT TLFPWVVELE HTVPRTPENE ARYAAVLRQL LADDGDDGPE VSDDAIARAL
EAAARAAEDQ QRLALTVGRF AGLLREAAAW AQAQGRKVVA RQDVEAAVRA RFARTGSAWR
ETIAAIADGT HLITTRGNRV GQVNGLVVFE SGEEAYGHPI RITASVRMGG EGEVLDIERE
SELGGSIHSK GVMILSAFLS GRFGRRRPLA LSATLVMEQS YGFVEGDSAS LAEALALLSA
IAGVPLEQSI AVTGSINQFG EVQAVGAINE KIEGWYAVCA AAGLDGSHGV ILPAANCRHL
MLDDAVIAAV RAGRFHLWPV RSVDEAAAVL TGRPIRGPQS LPARVADALA HFARWHDEKG
ASWRRPWQRR RE
//
