ID A0A2Z6DYB6_HYDTE Unreviewed; 951 AA.
AC A0A2Z6DYB6;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Multidrug ABC transporter ATP-binding protein {ECO:0000313|EMBL:BBD77338.1};
GN ORFNames=HPTL_1074 {ECO:0000313|EMBL:BBD77338.1};
OS Hydrogenophilus thermoluteolus (Pseudomonas hydrogenothermophila).
OC Bacteria; Pseudomonadota; Hydrogenophilia; Hydrogenophilales;
OC Hydrogenophilaceae; Hydrogenophilus.
OX NCBI_TaxID=297 {ECO:0000313|EMBL:BBD77338.1, ECO:0000313|Proteomes:UP000262004};
RN [1] {ECO:0000313|EMBL:BBD77338.1, ECO:0000313|Proteomes:UP000262004}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TH-1 {ECO:0000313|EMBL:BBD77338.1,
RC ECO:0000313|Proteomes:UP000262004};
RA Arai H.;
RT "Complete genome sequence of Hydrogenophilus thermoluteolus TH-1.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP018558; BBD77338.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2Z6DYB6; -.
DR KEGG; htl:HPTL_1074; -.
DR OrthoDB; 9776369at2; -.
DR Proteomes; UP000262004; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03230; ABC_DR_subfamily_A; 2.
DR Gene3D; 3.40.1710.10; abc type-2 transporter like domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR047651; ABC2_perm_RbbA.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR047817; ABC2_TM_bact-type.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; NF033858; ABC2_perm_RbbA; 1.
DR PANTHER; PTHR43038; ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1; 1.
DR PANTHER; PTHR43038:SF4; RIBOSOME-ASSOCIATED ATPASE; 1.
DR Pfam; PF12698; ABC2_membrane_3; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51012; ABC_TM2; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:BBD77338.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000262004};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 602..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 806..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 835..857
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 928..946
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..247
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 291..521
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 723..949
FT /note="ABC transmembrane type-2"
FT /evidence="ECO:0000259|PROSITE:PS51012"
FT REGION 254..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 951 AA; 105670 MW; CA5C1D24C893F06C CRC64;
MHAEAATDQP LIVLRNVTHR YGETVALSVP ELTLPPARTY GVIGPDGVGK STLLGLLATA
KRLQHGTIRF DGYDLHVRQD RQRLQERIAY MPQGLGKNLY PTLSVWENVT HFADLFALTE
PYRSQTIERL LTATDLWRFR DRPAGKLSGG MKQKLSLCCA LINDPDWLIL DEPTTGVDPL
SRRRFWNLIT QFQAERPQLR VIVATAYMEE AERFAHLLAL YGGRIIGQGD AEALKQATHT
QSLEAAFARL MTHAHDDRTV SRTPSSETAS ITPREAHEEA PSTADERPIV IAAEGLTQRF
GDFTAVDHVS FAIREGEIFG FLGSNGCGKT TTMKMLTGLL PPTEGESRLF GKPLAPNDLA
TRRLVGYMTQ QFSLYQELSV EPNLWLHARI FQMPEHEAHE RIESLLSQFD LTRYRDHTAE
SLPLGVKQRL SLAVAVLHRP KILILDEPTS GVDPVARDQF WALLYTLSRR ERVTIFLSTH
FMNEAMRCDR ISLMHAGKVL IQDTPDRIIA HYQADSLETA FIRALEAEEA QRGEAAPPTA
RVQNENPSPA RMAEQAPNRI EPQRQSTDSD SMRRRQPRFS LRRLASVAKR ESRELMRDPI
RLLFALLGAV VLMFVLASGI SLDVDRLPVV VYDADQSTES HDYIAQLDAT REFEVIGTAP
TLDALQAALQ NGSAAVGYAF PPGFGADLHR GRRVELGVWI DGSMPFRGET ARGYALAVHQ
AILAQWQQLS RGVDATLPIQ LAVRYRYNPE LRSVNAMAPA VIPLLLIFIP AILTALAVVR
EKELGSIVNL YVTPLRRAEF LVGKQLPYIA VSFVAFLLLL VQTRWGYGVP LKGDLLFLAA
ATLLYLLATT SFGLLISTVT RTQVAALFGT AILTMLPSIE FSGLTTPVSA SEGIARWIGE
GFPVSHYLTI SRGVITKALD GETLAHELIW LALFTLVTSA VAIWRLPKQE A
//
