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Database: UniProt
Entry: A0A2Z6DZP2_HYDTE
LinkDB: A0A2Z6DZP2_HYDTE
Original site: A0A2Z6DZP2_HYDTE 
ID   A0A2Z6DZP2_HYDTE        Unreviewed;      1176 AA.
AC   A0A2Z6DZP2;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=HPTL_1443 {ECO:0000313|EMBL:BBD77705.1};
OS   Hydrogenophilus thermoluteolus (Pseudomonas hydrogenothermophila).
OC   Bacteria; Pseudomonadota; Hydrogenophilia; Hydrogenophilales;
OC   Hydrogenophilaceae; Hydrogenophilus.
OX   NCBI_TaxID=297 {ECO:0000313|EMBL:BBD77705.1, ECO:0000313|Proteomes:UP000262004};
RN   [1] {ECO:0000313|EMBL:BBD77705.1, ECO:0000313|Proteomes:UP000262004}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TH-1 {ECO:0000313|EMBL:BBD77705.1,
RC   ECO:0000313|Proteomes:UP000262004};
RA   Arai H.;
RT   "Complete genome sequence of Hydrogenophilus thermoluteolus TH-1.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; AP018558; BBD77705.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2Z6DZP2; -.
DR   KEGG; htl:HPTL_1443; -.
DR   OrthoDB; 5287029at2; -.
DR   Proteomes; UP000262004; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd07433; PHP_PolIIIA_DnaE1; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000262004};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          9..76
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   1176 AA;  130357 MW;  1E53A83C7AD8C133 CRC64;
     MSTQAHPFVH LRLHTEFSIR EGIVKIPDAV KRAAAEGMPA LAITDVMNVF GLVKFYKACR
     SAGVKPIIGV DARVAHPDAP NDPERALELL LIVRNRDGYR QLCELVSRAW LENQHRGQAL
     LRPEWLTRET CAGLMALSGG ARGVLAPALL AGETRGAKAA LAHWAGCFPD GAFFVEVQRA
     GLPNEAEYLA AAVPFAAELG VPVVATHPIQ FLRPEDFTAH EVRFCIAEGY VLNDPNRPRP
     FTEAQYFLSA EEMADRFADL PEALENTLLI AQKANLTITL GKSFLPAFPT PEGMSLDEFF
     ISEAKRGLAA RLEERFPDPE ERERERPRYE QRLAFECDTI IQMGFPGYFL IVADFINWAK
     QNDVPVGPGR GSGAGSLVAY ALRITDLDPL SYALLFERFL NPERVSMPDF DVDFCQEKRY
     RVIDYVRRRY GAQAVSQIAT FGSMASKAVV RDVGRVLGLP YGLCDRISKL IPTEGVKPVS
     LAKALELEPQ LQELMEDPQD GEAIRQLFEL AQPLEGLTRN VGMHAGGVLI APGKITDFCP
     LFVQEGDDPS PVSQFDKDDV EAVGLVKFDF LGLRNLTIIR EALDQIERLT GARPDLARMG
     FDDPQTYQLL RDANTTAVFQ LESEGMKKLL KKLQPDRFED IIAVLALYRP GPLGSGMVDD
     FILRKQGKQA IDYFHPDLKA CLEPTYGVIV YQEQVMQIAQ IIGGYTLGAA DLLRRAMGKK
     KPEEMAKHRE IFRQGAIERG YDEALAMRLF DLMEKFAEYG FNKSHTAAYA VVTYQTAWLK
     RHHPAPFFAA TLSSDMDDTD AVKTFFDDAC ANGLTVLPPD VNVSEYRFQA IDAATIRYGL
     GAIKGVGEPA ANAIVTERQQ HGPFHDLFDL VSRVDRRVVN RRVLEQLVRA GALDTLPGHT
     HLRAPDGLCD RARLFASVGL ALEVAEQRAA SAQQCGLFDD EPEANGSYTP EFPAVRPWTE
     RERLKEEKLA IGFFLSGHPF TAFAAELRQT VPTKLADLAP SRDAVWVCGV VVELRTKMGA
     RGRMAFVTLD DGSEPCEVLF YREVYDAVRQ IVVVDEPLVV RVKVAPDDYS GGVRVVAEEA
     LSLPQWRARQ LKAIEITIPE SVVDSPVSAQ RLSETIEAFR VPSASPEGAK IEMRVTFSEG
     AVVALRAARD AIRVKPEDAL LTELRGFPEV NVALRY
//
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