ID A0A2Z6DZP2_HYDTE Unreviewed; 1176 AA.
AC A0A2Z6DZP2;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=HPTL_1443 {ECO:0000313|EMBL:BBD77705.1};
OS Hydrogenophilus thermoluteolus (Pseudomonas hydrogenothermophila).
OC Bacteria; Pseudomonadota; Hydrogenophilia; Hydrogenophilales;
OC Hydrogenophilaceae; Hydrogenophilus.
OX NCBI_TaxID=297 {ECO:0000313|EMBL:BBD77705.1, ECO:0000313|Proteomes:UP000262004};
RN [1] {ECO:0000313|EMBL:BBD77705.1, ECO:0000313|Proteomes:UP000262004}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TH-1 {ECO:0000313|EMBL:BBD77705.1,
RC ECO:0000313|Proteomes:UP000262004};
RA Arai H.;
RT "Complete genome sequence of Hydrogenophilus thermoluteolus TH-1.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AP018558; BBD77705.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2Z6DZP2; -.
DR KEGG; htl:HPTL_1443; -.
DR OrthoDB; 5287029at2; -.
DR Proteomes; UP000262004; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07433; PHP_PolIIIA_DnaE1; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000262004};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..76
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1176 AA; 130357 MW; 1E53A83C7AD8C133 CRC64;
MSTQAHPFVH LRLHTEFSIR EGIVKIPDAV KRAAAEGMPA LAITDVMNVF GLVKFYKACR
SAGVKPIIGV DARVAHPDAP NDPERALELL LIVRNRDGYR QLCELVSRAW LENQHRGQAL
LRPEWLTRET CAGLMALSGG ARGVLAPALL AGETRGAKAA LAHWAGCFPD GAFFVEVQRA
GLPNEAEYLA AAVPFAAELG VPVVATHPIQ FLRPEDFTAH EVRFCIAEGY VLNDPNRPRP
FTEAQYFLSA EEMADRFADL PEALENTLLI AQKANLTITL GKSFLPAFPT PEGMSLDEFF
ISEAKRGLAA RLEERFPDPE ERERERPRYE QRLAFECDTI IQMGFPGYFL IVADFINWAK
QNDVPVGPGR GSGAGSLVAY ALRITDLDPL SYALLFERFL NPERVSMPDF DVDFCQEKRY
RVIDYVRRRY GAQAVSQIAT FGSMASKAVV RDVGRVLGLP YGLCDRISKL IPTEGVKPVS
LAKALELEPQ LQELMEDPQD GEAIRQLFEL AQPLEGLTRN VGMHAGGVLI APGKITDFCP
LFVQEGDDPS PVSQFDKDDV EAVGLVKFDF LGLRNLTIIR EALDQIERLT GARPDLARMG
FDDPQTYQLL RDANTTAVFQ LESEGMKKLL KKLQPDRFED IIAVLALYRP GPLGSGMVDD
FILRKQGKQA IDYFHPDLKA CLEPTYGVIV YQEQVMQIAQ IIGGYTLGAA DLLRRAMGKK
KPEEMAKHRE IFRQGAIERG YDEALAMRLF DLMEKFAEYG FNKSHTAAYA VVTYQTAWLK
RHHPAPFFAA TLSSDMDDTD AVKTFFDDAC ANGLTVLPPD VNVSEYRFQA IDAATIRYGL
GAIKGVGEPA ANAIVTERQQ HGPFHDLFDL VSRVDRRVVN RRVLEQLVRA GALDTLPGHT
HLRAPDGLCD RARLFASVGL ALEVAEQRAA SAQQCGLFDD EPEANGSYTP EFPAVRPWTE
RERLKEEKLA IGFFLSGHPF TAFAAELRQT VPTKLADLAP SRDAVWVCGV VVELRTKMGA
RGRMAFVTLD DGSEPCEVLF YREVYDAVRQ IVVVDEPLVV RVKVAPDDYS GGVRVVAEEA
LSLPQWRARQ LKAIEITIPE SVVDSPVSAQ RLSETIEAFR VPSASPEGAK IEMRVTFSEG
AVVALRAARD AIRVKPEDAL LTELRGFPEV NVALRY
//