ID A0A2Z6E0U8_HYDTE Unreviewed; 569 AA.
AC A0A2Z6E0U8;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=HPTL_P066 {ECO:0000313|EMBL:BBD78411.1};
OS Hydrogenophilus thermoluteolus (Pseudomonas hydrogenothermophila).
OG Plasmid pth1 dna {ECO:0000313|Proteomes:UP000262004}.
OC Bacteria; Pseudomonadota; Hydrogenophilia; Hydrogenophilales;
OC Hydrogenophilaceae; Hydrogenophilus.
OX NCBI_TaxID=297 {ECO:0000313|EMBL:BBD78411.1, ECO:0000313|Proteomes:UP000262004};
RN [1] {ECO:0000313|EMBL:BBD78411.1, ECO:0000313|Proteomes:UP000262004}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TH-1 {ECO:0000313|EMBL:BBD78411.1,
RC ECO:0000313|Proteomes:UP000262004};
RC PLASMID=pth1 dna {ECO:0000313|Proteomes:UP000262004};
RA Arai H.;
RT "Complete genome sequence of Hydrogenophilus thermoluteolus TH-1.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; AP018559; BBD78411.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2Z6E0U8; -.
DR KEGG; htl:HPTL_P066; -.
DR OrthoDB; 5318045at2; -.
DR Proteomes; UP000262004; Plasmid pth1 dna.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Plasmid {ECO:0000313|EMBL:BBD78411.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000262004}.
FT DOMAIN 73..341
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 94..101
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 569 AA; 64865 MW; 5A023FB6CE7D72D2 CRC64;
MSFFGKVFAK KAIASTDERH EPKEPIKPVV VSPSEAEKVA NDHDFVDTQL AQAIEAVARE
EMRQKVAVRL PHAQMTDEQR DVVESTAPFL AVNAYAGAGK THTLKNFALA RSDEKLLYVC
FNRSLAEEAK RKMPNNVRVG TIHAICFNEF ARHVYKDING KFSGKPTSAD IYEASDFIRL
KLGLTEEGWK RFYFPKIIRL LEQFTNSDAL DLRQFLEKAF AEEIAHKRLE PFVIDAAIET
WNLIADPRSK ITAWHDVYVK MWHLSNPSIS GGYQYILLDE AQDVSPVMYD IFLRQEHLTR
VLVGDRHQCI YGFRGAMNAM QHAVDHGNAT EKYMTQSFRF GNEVALLASL ILQSWKKETR
PVRGNPAIQD EVRKATTVFD LAPSEQSAYL ARTNGKLIDT AISLMEKKIP FQFLGEVKDY
RLLMAKEVAF LKANKRDKLG TYLRKFKSYA DYKEQAERED DQEKQAICRL VEKYGKDLPQ
LVESLERTVS KQGVVLTTAH KSKGAEWAEV MLADDFPSLI NLRSTSKLNA ISDQEANLYY
VAVTRAQRTL YVPNDCYQFY RAGKRVQGG
//
