ID A0A2Z6GC47_9PROT Unreviewed; 730 AA.
AC A0A2Z6GC47;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Tyrosine-protein kinase etk {ECO:0000313|EMBL:BBE51017.1};
GN ORFNames=OYT1_ch1463 {ECO:0000313|EMBL:BBE51017.1};
OS Ferriphaselus amnicola.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Gallionellaceae; Ferriphaselus.
OX NCBI_TaxID=1188319 {ECO:0000313|EMBL:BBE51017.1, ECO:0000313|Proteomes:UP000033070};
RN [1] {ECO:0000313|EMBL:BBE51017.1, ECO:0000313|Proteomes:UP000033070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OYT1 {ECO:0000313|EMBL:BBE51017.1,
RC ECO:0000313|Proteomes:UP000033070};
RA Kato S., Itoh T., Ohkuma M.;
RT "OYT1 Genome Sequencing.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; AP018738; BBE51017.1; -; Genomic_DNA.
DR RefSeq; WP_062627587.1; NZ_AP018738.1.
DR AlphaFoldDB; A0A2Z6GC47; -.
DR STRING; 1188319.OYT1_02487; -.
DR KEGG; fam:OYT1_ch1463; -.
DR OrthoDB; 9808257at2; -.
DR Proteomes; UP000033070; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:BBE51017.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000033070};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 40..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..114
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 390..461
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 531..671
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT COILED 264..320
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 730 AA; 79452 MW; 29CF7734E2DC738E CRC64;
MSEVLHSEKH HSIPSAAHQT DDQLELLVYW RSVVKRKWSI LGLAAAMTLL AAVVVFMMTP
IYRSTVTILI EQNKTKVVSI EDVYSGIGQG KEYIQTQSEI IKSLSLAKVV VDKLKLTKHP
EFDPRVNTSW LHSLLATLGA SGKEPTEAEI RDAVAARLAN SLTVEPVKMS QLIKVSFDSP
DSQLAAKVAN AVAEAFVESD MEAKFQMTQR ASNWLNEHLA GLKVDLQKSE QALQEYRDRE
HIVDAGNLEL SGASNQLQGL LASLVNARMN RAQAESAYKQ VKNAGDSLES LPVVQKDPLA
AKLKEVVAEK ERKVSELANR YGKEHVKMIQ AQADLDQARD GLRRHVDVVV AGLQREYEVA
RANEGALAGA VAEAKGTIQG ANKKGFELSS LERDVATNKQ IYDTFLSRFK ETSATGDSGA
LVGRVIDPAT PAVSPIKPKK GMVIAVAFVL GLLLGVAVAL LLDRLDNTVR STEDAELKLG
QPILSTLPLL EGNDDQHMGR YYLDEPRSVF AESVRTARTG VLLSAIDCPN KILVITSSVP
GEGKTTVSSN LALSHAQTKR VLLIDADMRR PSVAKVMNLD MAKQGLSALV TGTATLEECT
QTIEGSTLHV VTAGSIPPNP LELLLSNKFE ELLKSLSEKY DMVIIDSPPV QLVSDAVVLS
TMATGVVFVV KADSTPHQVA RRCIKTLLEA EATLFGVTLN QLDFRKAESY YGAYTGYGKY
GYDGYYTKET
//
