ID   A0A2Z6IAV9_9BURK        Unreviewed;       743 AA.
AC   A0A2Z6IAV9;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   ORFNames=SUTMEG_15540 {ECO:0000313|EMBL:BBF23663.1};
OS   Sutterella megalosphaeroides.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Sutterellaceae; Sutterella.
OX   NCBI_TaxID=2494234 {ECO:0000313|EMBL:BBF23663.1, ECO:0000313|Proteomes:UP000271003};
RN   [1] {ECO:0000313|EMBL:BBF23663.1, ECO:0000313|Proteomes:UP000271003}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6FBBBH3 {ECO:0000313|EMBL:BBF23663.1,
RC   ECO:0000313|Proteomes:UP000271003};
RX   PubMed=30394865; DOI=10.1099/ijsem.0.003096;
RA   Sakamoto M., Ikeyama N., Kunihiro T., Iino T., Yuki M., Ohkuma M.;
RT   "Mesosutterella multiformis gen. nov., sp. nov., a member of the family
RT   Sutterellaceae and Sutterella megalosphaeroides sp. nov., isolated from
RT   human faeces.";
RL   Int. J. Syst. Evol. Microbiol. 68:3942-3950(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR   EMBL; AP018786; BBF23663.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2Z6IAV9; -.
DR   KEGG; sutt:SUTMEG_15540; -.
DR   Proteomes; UP000271003; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 1.10.287.130; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR   PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF12974; Phosphonate-bd; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000271003};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        384..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          449..662
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   REGION          681..743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        700..723
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   743 AA;  81352 MW;  743FC5E14E1ECD45 CRC64;
     MGTTTGTPSS DIRAAIRPDM AEIPEPEAIK NAKISADALV GVPVISERMR IGRPIRIGIE
     AELGRTQYAS WIRYTLEALR HALGKKNVQV FYLDGRGLSV ALQNSEIDFF IANSHTFALQ
     QSKTTVEQLA TFLPVDALRA EEAQAGVLFM KKGALEGNML ARNDAGGSTS ATTVATQRAV
     TSDGTATVFT STGSRVSERQ NLQHLIESLK EGGIVAVERT SLGGWLAPLA LLQREGLSAQ
     AAGRRTTFTN GDERAVLDAV LSGEAVLGIL PACSLERFQE AGVVDVKRDL VIVDPQLADG
     LACAHSTPTY PGWAFGTTAK TDPLLKKNIG SLLFSMNADR YGGQWQFPAL NRSIYDLFYE
     LKMGPYEHLA TWSLHRFMRE NSEALALIIF LTFVVISYAV SLSVLVRRKT QQLRDALHDR
     DLVEAEAAQS RQHIANLERT GIVGQMSTII AHELKQPLSA ISNYANSLHR RTKNDKFDKE
     SFIWALTEIA NEAERASRIV DRVRSYAKHD YPPRTVTDLS VVIGNSITTF RRSRQTNAEI
     VVRVNPGSMA EVDAWEIELA VLNLLKNAAD AISGVEKPRI EVSLVARDAK TWALSVGDNG
     PYISDEQLAL FFKPLQTTKG AKGMGLGLSI VANIAERHAG RVTVERNGTA GVRFTITFPR
     LPGETEKPIE DAMLPPRMTV YEGNPKPAKS AGMLDAQIRS EVDRAAERDH PSERSDRTPG
     EDTPVTIHSR GFSRMLDRLE GKS
//