ID A0A2Z6R8A9_9GLOM Unreviewed; 1738 AA.
AC A0A2Z6R8A9;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE AltName: Full=ATP pyrophosphate-lyase {ECO:0000256|ARBA:ARBA00032597};
DE AltName: Full=Adenylyl cyclase {ECO:0000256|ARBA:ARBA00032637};
GN ORFNames=RclHR1_22770003 {ECO:0000313|EMBL:GBB94024.1};
OS Rhizophagus clarus.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Glomeromycotina;
OC Glomeromycetes; Glomerales; Glomeraceae; Rhizophagus.
OX NCBI_TaxID=94130 {ECO:0000313|EMBL:GBB94024.1, ECO:0000313|Proteomes:UP000247702};
RN [1] {ECO:0000313|EMBL:GBB94024.1, ECO:0000313|Proteomes:UP000247702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HR1 {ECO:0000313|EMBL:GBB94024.1,
RC ECO:0000313|Proteomes:UP000247702};
RA Kobayashi Y.;
RT "The genome of Rhizophagus clarus HR1 reveals common genetic basis of
RT auxotrophy among arbuscular mycorrhizal fungi.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays essential roles in regulation of cellular metabolism by
CC catalyzing the synthesis of a second messenger, cAMP.
CC {ECO:0000256|ARBA:ARBA00003896}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBB94024.1}.
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DR EMBL; BEXD01001421; GBB94024.1; -; Genomic_DNA.
DR STRING; 94130.A0A2Z6R8A9; -.
DR Proteomes; UP000247702; Unassembled WGS sequence.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd00143; PP2Cc; 1.
DR CDD; cd17214; RA_CYR1_like; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF45; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 10B; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00364; LRR_BAC; 10.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00332; PP2Cc; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS51746; PPM_2; 1.
DR PROSITE; PS50200; RA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000247702};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 365..455
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1042..1319
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT DOMAIN 1385..1523
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1738 AA; 195769 MW; FCC1F49BFB9194AC CRC64;
MTPRRSSDLD ISPPSPFRTP EQYPTGGGQN RRKKSREEKD SFLSSIFGSH SRPSSPSYDP
TLQSMNNLAA RSSKRGGLVR KLSAGNVKAG LLLPDDDEPR RKSFDSVQPN MNTRYGDFPP
EEIAPFAYQT VIPMDNRKGS STTLSSNSDT NSYRIIHRRT KSSDSDSALD SSSVYSNNGP
IGKEKEKRTI LKWFRKSPKD KETSTSEGIF RKNSDAETYT HSHPNLIITP YEKDEFAPIT
PNYSRSTSLK SEKSDHHLFK IKKGSSGRRK ETTQNEFNLD IDDMDGIIRN DNREHRLSGV
SNTLQFITCD EMLQESSNDS ILTPTSNTEM WSPPESWAVH KPQQHILESN ILDDTNNEKL
NNGNKMYCIR VFRPDATFGT VNCLLNTTTA ELCHILGKKF YIPDISKYNI YIKRHNLERM
LSPKERPLKL QKQLLEQTGY TENDKLDDLG REDNSYLFRF TFRETTVPRF EEEQGALSSI
QHVDLQARNL QTIPIFLYRQ AYFIRSLNVS QNLMLDLPTD FIQSCHQLKE LHLSQNELER
VPQSVKQSQM LSTLNLSSNR LQELDHAQLE QLKNVIELTN LQVDNNLLSS LPETFVKFRC
LNILNVSNNS FTEFPPVICS IISLSELDMS FNNITDVPIE IGNLVNLKRL FLIGNQIMGT
LPASFEKLTS LRKLDIRRNQ ITNIDVLSSV PNLEVLLIES NHFSLVNEGI GSSITELSLA
HSKLNELPDR LLEDLVSLEK LDLSNNQLTK IPNSIGSLKK LAHFSCKNNT LSALPSEIGS
LTALRVLDIH CNNLRSLPPE IWYCAGLVTL NVSSNLLEQF PMRPTSFPDV NQSINSVRPN
SYLSKSLRAL YLGDNVLTTE IFSAVSQFIE LRILNLSFNL LDEIPTGGIV NPHLTELYLS
GNEIPSLPDD IEKLANLRVL HVNGNKLQTL PAELSKIRKL VVLDVGNNAL KYNIANWHFE
WNWNWNIELK YLNLSGNKRL KIKHALFNEL NPPRDRNLAD FGALTRLRVL GLMDITLLDL
IVPDETDNRR VRTSGSEVNS MSYGMADTLG TSDNLSTWEA VIPKFRGRED ECLFGLFEGR
AGTNRGGRVA KYLHDNFQSS FKTELERLKD FDQVESSLRR SFLSLNKELG LKMFNSNNSA
LESEYAWESE STNSVALGID DNKSGASGIV VYISGTILYV ANVGDTKAVI GRNNGSAYEV
ACNQSIISPS EIARIRDAGG FISHDCLVNG EVNVSRSFGH FHLTPIINAN PSIEKIKLSE
QDEFIVLATR GLWDRMSYQT AVDVTRTERD DLMRAAQKLR DFAISYGAEE NIMVMIIGVG
DLFDRRLRRR LDGLEGKGLL QGMAGEETTF YFGSKTKRGR REENPSDSAI ARLQKEIPPP
TGQIALVFTD IKNSTFLWET LPDAMRSAIK QHNTIMRRQL RFIGGYEVKT EGDAFMVSFP
TVSSALLWCF TVQLELLKVD WPSEIIESED GKIVYGGADN DLIYKGLSVR MGIHWGSPVC
EPDIITKRMD YFGPIVNRTA RICNNADGGQ ICISSDVKTE IGLLDGMMDG GDNDSIFKKD
GTDEEMQGTP PQSNNGVLDK NLIHLRKLGF VMRNIGERKL KGLENPEVLY LVYPEALKGR
MEEDLVKDKD SKSLDPAIVR LCGQLCLRLE RLSSGGVINR SNTRNSRLDL FLSGLSYVKD
NATEEELLRI MESFVTRIEN SISTLYLKDV GKLALGDMSI MDIVKALQMY AQYVGKAK
//
