ID A0A2Z6S3R2_9GLOM Unreviewed; 1050 AA.
AC A0A2Z6S3R2;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 22-FEB-2023, entry version 9.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=RCL2_000857100 {ECO:0000313|EMBL:GES81319.1}, RclHR1_00530015
GN {ECO:0000313|EMBL:GBC03740.1};
OS Rhizophagus clarus.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Glomeromycotina;
OC Glomeromycetes; Glomerales; Glomeraceae; Rhizophagus.
OX NCBI_TaxID=94130 {ECO:0000313|EMBL:GBC03740.1, ECO:0000313|Proteomes:UP000247702};
RN [1] {ECO:0000313|EMBL:GBC03740.1, ECO:0000313|Proteomes:UP000247702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HR1 {ECO:0000313|EMBL:GBC03740.1,
RC ECO:0000313|Proteomes:UP000247702};
RA Kobayashi Y.;
RT "The genome of Rhizophagus clarus HR1 reveals common genetic basis of
RT auxotrophy among arbuscular mycorrhizal fungi.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GES81319.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HR1 {ECO:0000313|EMBL:GES81319.1};
RA Maeda T., Kobayashi Y., Nakagawa T., Ezawa T., Yamaguchi K., Bino T.,
RA Nishimoto Y., Shigenobu S., Kawaguchi M.;
RT "Conservation and host-specific expression of non-tandemly repeated
RT heterogenous ribosome RNA gene in arbuscular mycorrhizal fungi.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBC03740.1}.
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DR EMBL; BEXD01003904; GBC03740.1; -; Genomic_DNA.
DR EMBL; BLAL01000054; GES81319.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2Z6S3R2; -.
DR STRING; 94130.A0A2Z6S3R2; -.
DR Proteomes; UP000247702; Unassembled WGS sequence.
DR Proteomes; UP000615446; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000247702};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 41..301
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 556..1000
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1050 AA; 118560 MW; 76A850C49BEA72B2 CRC64;
MERLVRNYMI TSNEATEEAK SIVYEIVYNI KSGQATLITL VQVLGEFLTN EDGTIRAKGT
GLLSTVLADC PQEQVNNAAI NVLVDFYCER LSDTASVPEL LQGIESLAHF NSFHNENSLK
VAKSIFASVN VQSFQQTTRH YVFQIFDRLL KHHLNALKQM RQDFVTGFIQ AMDGEKDPRN
LLLAFSLIKL IIHEFDISQH VELLFEVTFC YFPITFKPPP DDPYGITADD LKIALRECLS
ATPYFAELAM PLLLEKLTSS SGNAKKDSME TLTACAPVYG AKSIVPYLED LWDYLKDEIV
NATDDSFEDI ALEAIKSIVA TLSSGIINRM DHLQQFLKTV VTECMENLKE PELKLAKPCG
KILMYCAMAS DPAFNIVMLA TLRVLIQQYK ENELATRKKG ILEVLRVFIT ASKILYGSIE
NPLENLDADF VTPLSTFKDS YMEIFSSALL NQNEYSDLRL CGLLGLHDMI LLHQFLNDEE
IGIILQYFNR AVLEEIDQEI SNEALKSLAD IAKYKPNIVL EVTLPVFLDN LPCDKDEMKI
DIIRGMNVKE ANYVKILDAL SELAIEPILF EAYVPQILNK LDFASSTEND LEYSESLLKS
LHSLLLKKTN HSDISRYVEV IVPHLLTKSI GPSLYDKSEV NNTIQCVFFD KKVIKIVTGI
ISVITKNLNA SEQSIFISQM FEIFVKGNLN LKYLGFSDQE KASFSVEFNP LSVESSFHQQ
NLTLLFTAAV GSCRKEVPYP LPNISEFLSK IIEISLNTKN ELQRHSLAQL GASILNKWNQ
ESELSQFIET KILGELRNHF ALSSTGNEAI RQTSLDIFIW LTKALILRAH ILGYRCIDQI
TSRFNDQTLG KRASEGFEVL IGESDSLNKQ SFAVIKTLYK QRFFNYCMPI LAEGFKLSND
EVKHNYLIAL SHLLRNIPKQ VLLSELPPLI PLLIYSLSLP DAELKSSTID TFYIISANAP
HIISEHVSSL IPLLLSSTKV DKGNTMRVRI SALQCLGILP DHVPFDVLFP FKSKILRELS
AALDDKKRLV RKQAVDCRSK WFLFIGPRTD
//
