ID A0A310TPM0_XENLA Unreviewed; 522 AA.
AC A0A310TPM0; A0A974BRZ7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=LOC108704994 {ECO:0000313|RefSeq:XP_018097227.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018097227.1};
RN [1] {ECO:0000313|RefSeq:XP_018097227.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018097227.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018097227.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
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DR RefSeq; XP_018097227.1; XM_018241738.2.
DR AlphaFoldDB; A0A310TPM0; -.
DR PaxDb; 8355-A0A310TPM0; -.
DR GeneID; 108704994; -.
DR KEGG; xla:108704994; -.
DR Proteomes; UP000186698; Chromosome 1S.
DR Bgee; 108704994; Expressed in oocyte and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR CDD; cd19769; Bbox2_TRIM16-like; 1.
DR CDD; cd12891; SPRY_PRY_C-I_2; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25465:SF39; B BOX AND SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT REGION 198..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 59295 MW; 529C1F94E3444542 CRC64;
MAAADLRAEL SCSICTSIYT DPVSLPCGHN FCQVCIGTTW DTQEETFQEN PSCPECRNRF
SRRPELTTDW KLRGLVEKFC LTETEPGETG IFCTYCVLSP VPAAKSCLLC EASLCETHLR
GHSKSAEHVL TQPTDSFMGR KCSVHHKVLE YYCCEESVCI CVSCCLAGEH RGHRVELLSE
ASEKKKETLR KVLEKLRPER EETERGAQRL QERRREVAEK AAGEKERVTA LFRDIREQLE
ALEKRLLSNI SSQKEKLTLT DLMEQLEIKK DELSRKIRHI EELCNMADPL TVLQERESHG
AADNEGGRER HDIKVPAVGD LDVDLISETL LTGLAAIVTG VKGRIYGQEA TDLLLDINTA
HNPVSVSGDR KSASYSLTDQ RHPQTPERFH VPQTLSSRSF PSGRHYWEVE VSESGNWRVG
VAYPSIERRG GQSLIGINNK SWCLWRWNNK YTVRHDSKDT QLPHVPSSRR IRISLDYEAG
RLSFYELSEP IRHLHTFTAT FTEPLHAAFC VWGDNVWVRI IS
//
