ID A0A314KQA7_NICAT Unreviewed; 478 AA.
AC A0A314KQA7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Protein DETOXIFICATION {ECO:0000256|RuleBase:RU004914};
DE AltName: Full=Multidrug and toxic compound extrusion protein {ECO:0000256|RuleBase:RU004914};
GN Name=DTX2 {ECO:0000313|EMBL:OIT31508.1};
GN ORFNames=A4A49_37068 {ECO:0000313|EMBL:OIT31508.1};
OS Nicotiana attenuata (Coyote tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=49451 {ECO:0000313|EMBL:OIT31508.1, ECO:0000313|Proteomes:UP000187609};
RN [1] {ECO:0000313|EMBL:OIT31508.1, ECO:0000313|Proteomes:UP000187609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. UT {ECO:0000313|Proteomes:UP000187609};
RC TISSUE=Leaves {ECO:0000313|EMBL:OIT31508.1};
RA Xu S., Brockmoeller T., Gaquerel E., Navarro A., Kuhl H., Gase K., Ling Z.,
RA Zhou W., Kreitzer C., Stanke M., Tang H., Lyons E., Pandey P., Pandey S.P.,
RA Timmermann B., Baldwin I.T.;
RT "The genome of Nicotiana attenuata.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199,
CC ECO:0000256|RuleBase:RU004914}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIT31508.1}.
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DR EMBL; MJEQ01001256; OIT31508.1; -; Genomic_DNA.
DR RefSeq; XP_019227270.1; XM_019371725.1.
DR AlphaFoldDB; A0A314KQA7; -.
DR EnsemblPlants; OIT31508; OIT31508; A4A49_37068.
DR GeneID; 109208595; -.
DR Gramene; OIT31508; OIT31508; A4A49_37068.
DR KEGG; nau:109208595; -.
DR OrthoDB; 732716at2759; -.
DR Proteomes; UP000187609; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR PANTHER; PTHR11206:SF255; PROTEIN DETOXIFICATION 5-RELATED; 1.
DR Pfam; PF01554; MatE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004914};
KW Reference proteome {ECO:0000313|Proteomes:UP000187609};
KW Transmembrane {ECO:0000256|RuleBase:RU004914};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004914}.
FT TRANSMEM 34..56
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 62..87
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 108..130
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 150..168
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 180..202
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 208..225
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 333..357
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 369..390
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 402..427
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 433..457
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
SQ SEQUENCE 478 AA; 52338 MW; 196BCC61D27966B9 CRC64;
MEEQLLENGE NSRWIITREW HTTYYEELKK LTRIAAPMVA VSVLQYLLQV VSVMMVGHLD
QISLSSVAIA TSITNVTGFS LLSGLVGGLE TLCGQAFGAQ QWQRVGTYTY SAIISLLLVC
IPISILWLFM DKLLILMGQD PVISVEASKY SMWLIPALFG GAILRPIFRY LQIQSLILPM
LLSAFVVLCL HISLCYLFIF HLGLGKSGAA IAFSFSIWTF VALLVSYIKR SSSCERTRTP
LIKDAFLAIG QFFRYATPSA LMVCLKWWSL EVLILLSGLL PNPKLETSVL SICLTISALH
FSIPFGLGAG ASTRVSNELG SGNPQKALVA VRVAMFLAVA ETVVVSTVTF LCRGILGKAY
SNDQQVVDYV AAITPFLCLS IITDSLQAVI SGIARGSGWQ IIGAYVNLGA FYLVGIPVSA
ILCFLIHLRA KGLWIGLLVG SAIQATTLSF ILGFIDWQKQ AIKAKKRISE RRSSEENE
//
