ID A0A314KRI0_NICAT Unreviewed; 376 AA.
AC A0A314KRI0;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:OIT31936.1};
GN Name=ADH {ECO:0000313|EMBL:OIT31936.1};
GN ORFNames=A4A49_10534 {ECO:0000313|EMBL:OIT31936.1};
OS Nicotiana attenuata (Coyote tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=49451 {ECO:0000313|EMBL:OIT31936.1, ECO:0000313|Proteomes:UP000187609};
RN [1] {ECO:0000313|EMBL:OIT31936.1, ECO:0000313|Proteomes:UP000187609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. UT {ECO:0000313|Proteomes:UP000187609};
RC TISSUE=Leaves {ECO:0000313|EMBL:OIT31936.1};
RA Xu S., Brockmoeller T., Gaquerel E., Navarro A., Kuhl H., Gase K., Ling Z.,
RA Zhou W., Kreitzer C., Stanke M., Tang H., Lyons E., Pandey P., Pandey S.P.,
RA Timmermann B., Baldwin I.T.;
RT "The genome of Nicotiana attenuata.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIT31936.1}.
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DR EMBL; MJEQ01001166; OIT31936.1; -; Genomic_DNA.
DR RefSeq; XP_019226592.1; XM_019371047.1.
DR AlphaFoldDB; A0A314KRI0; -.
DR STRING; 49451.A0A314KRI0; -.
DR EnsemblPlants; OIT31936; OIT31936; A4A49_10534.
DR GeneID; 109208045; -.
DR Gramene; OIT31936; OIT31936; A4A49_10534.
DR KEGG; nau:109208045; -.
DR OrthoDB; 1205866at2759; -.
DR Proteomes; UP000187609; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43880:SF45; ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000187609};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 20..374
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 376 AA; 41164 MW; 4003CBDF69DFF383 CRC64;
MNSGGHKVIS CKAAVVWKSG EELKLEEIEV DPPNSTEVRI KMIYASLCGT DVLCCNGFPK
PLFPRIPGHE GVGVVESVGE KVKNLKEGDI VIPHFLGECG ECPNCKSKKS NLCHKYPLNF
SGLLLDGTSR MSIKGQRIYH HVSCSTLSEY LVVDENYVIK VDPRLPVEHA AFLCCAFTTG
FGATFKDVNI EKGSTVAVLG LGGVGLGVVE GAKQKEAAKI IGIDIHEMKS EKAKKFGITD
FINIKVSEKS VSELVKDATG GLGVDYFFEC TNVPDLMINE AIQSTRMGYG TVILLGAGLE
LDWQMSYVPI MFGRTLKGSI YGGIRTRTDL PSVFDKCINK EIKLDELLTH EVSLNDINKA
FEYLKEPNCV KVLIKF
//
