ID A0A314L0J1_NICAT Unreviewed; 613 AA.
AC A0A314L0J1;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=prolycopene isomerase {ECO:0000256|ARBA:ARBA00012419};
DE EC=5.2.1.13 {ECO:0000256|ARBA:ARBA00012419};
GN Name=CRTISO_2 {ECO:0000313|EMBL:OIT34514.1};
GN ORFNames=A4A49_03802 {ECO:0000313|EMBL:OIT34514.1};
OS Nicotiana attenuata (Coyote tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=49451 {ECO:0000313|EMBL:OIT34514.1, ECO:0000313|Proteomes:UP000187609};
RN [1] {ECO:0000313|EMBL:OIT34514.1, ECO:0000313|Proteomes:UP000187609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. UT {ECO:0000313|Proteomes:UP000187609};
RC TISSUE=Leaves {ECO:0000313|EMBL:OIT34514.1};
RA Xu S., Brockmoeller T., Gaquerel E., Navarro A., Kuhl H., Gase K., Ling Z.,
RA Zhou W., Kreitzer C., Stanke M., Tang H., Lyons E., Pandey P., Pandey S.P.,
RA Timmermann B., Baldwin I.T.;
RT "The genome of Nicotiana attenuata.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=7,7',9,9'-tetra-cis-lycopene = all-trans-lycopene;
CC Xref=Rhea:RHEA:30971, ChEBI:CHEBI:15948, ChEBI:CHEBI:62466;
CC EC=5.2.1.13; Evidence={ECO:0000256|ARBA:ARBA00000004};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- COFACTOR:
CC Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00001937};
CC -!- PATHWAY: Carotenoid biosynthesis; lycopene biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004900}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast membrane
CC {ECO:0000256|ARBA:ARBA00004258}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004258}.
CC -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.
CC CrtISO subfamily. {ECO:0000256|ARBA:ARBA00005855}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIT34514.1}.
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DR EMBL; MJEQ01000700; OIT34514.1; -; Genomic_DNA.
DR RefSeq; XP_019267235.1; XM_019411690.1.
DR AlphaFoldDB; A0A314L0J1; -.
DR STRING; 49451.A0A314L0J1; -.
DR EnsemblPlants; OIT34514; OIT34514; A4A49_03802.
DR GeneID; 109244581; -.
DR Gramene; OIT34514; OIT34514; A4A49_03802.
DR KEGG; nau:109244581; -.
DR OrthoDB; 854at2759; -.
DR UniPathway; UPA00803; -.
DR Proteomes; UP000187609; Unassembled WGS sequence.
DR GO; GO:0031969; C:chloroplast membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046608; F:carotenoid isomerase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016117; P:carotenoid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.90.660.50; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR014101; CrtISO.
DR InterPro; IPR045892; CrtISO-like.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR NCBIfam; TIGR02730; carot_isom; 1.
DR PANTHER; PTHR46313; -; 1.
DR PANTHER; PTHR46313:SF3; PROLYCOPENE ISOMERASE, CHLOROPLASTIC; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Isomerase {ECO:0000313|EMBL:OIT34514.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Reference proteome {ECO:0000313|Proteomes:UP000187609}.
FT DOMAIN 105..585
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 613 AA; 67088 MW; 49818FE02F0AEFD2 CRC64;
MGTLNFMFPN SLLDGNYKIV ALGDSKLRNN KKISSYFDPL RIGNFTGVQQ LHGLSLGLNK
TKGRKGGIVS QLKAVVDKVV ESYGVGDVEV NESGNYDAIV IGSGIGGLVA ATQLAVKGAK
VLVLEKYVIP GGSSGFYQRG GYTFDVGSSV MFGFSDKGNL NLITQALAAV GCKLEVIPDP
TTVHFHLPND LSVRVHREYD DFIQELVSKF PHEKEGIIKF YSECWKIFNS LNSLELKSLE
EPIYLFGQFF KKPLECLTLA YYLPQNAGDI ARKYIKDPVL LSFIDAECFI VSTVNALQTP
MINASMVLCD RHFGGINYPV GGVGEIAKSL AKGLVNQGSQ ILYRANVTSI ILDNGKAVGV
KLSDGRKFYA KTIVSNATRW DTFGKLLKAE NLPKEEEAFQ KAYVKAPSFL SIHMGVKADV
LPPDTDCHHF TLEDNWTNLE KPYGSIFLSI PTVLDSSLAP EGHHILHIFT TANIEDWEGL
SLKDYEAKKE LVAERIIGRL EKTLFPGLKS SIVFKEVGTP KTHRRYLARD SGTYGPMPRG
TPKGLLGMPF NTTAIDGLYC VGDSCFPGQG VIAVAFSGVM CAHRVAADLG FEKKSEVLDS
GLLRLLGWLR TLA
//
