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Database: UniProt
Entry: A0A314L2X9_NICAT
LinkDB: A0A314L2X9_NICAT
Original site: A0A314L2X9_NICAT 
ID   A0A314L2X9_NICAT        Unreviewed;       491 AA.
AC   A0A314L2X9;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   08-NOV-2023, entry version 17.
DE   RecName: Full=3-ketoacyl-CoA synthase {ECO:0000256|PIRNR:PIRNR036417};
DE            EC=2.3.1.- {ECO:0000256|PIRNR:PIRNR036417};
GN   Name=KCS2_0 {ECO:0000313|EMBL:OIT35324.1};
GN   ORFNames=A4A49_22877 {ECO:0000313|EMBL:OIT35324.1};
OS   Nicotiana attenuata (Coyote tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=49451 {ECO:0000313|EMBL:OIT35324.1, ECO:0000313|Proteomes:UP000187609};
RN   [1] {ECO:0000313|EMBL:OIT35324.1, ECO:0000313|Proteomes:UP000187609}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. UT {ECO:0000313|Proteomes:UP000187609};
RC   TISSUE=Leaves {ECO:0000313|EMBL:OIT35324.1};
RA   Xu S., Brockmoeller T., Gaquerel E., Navarro A., Kuhl H., Gase K., Ling Z.,
RA   Zhou W., Kreitzer C., Stanke M., Tang H., Lyons E., Pandey P., Pandey S.P.,
RA   Timmermann B., Baldwin I.T.;
RT   "The genome of Nicotiana attenuata.";
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-
CC         chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736;
CC         EC=2.3.1.199; Evidence={ECO:0000256|ARBA:ARBA00001906};
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005194, ECO:0000256|PIRNR:PIRNR036417}.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC       ECO:0000256|PIRNR:PIRNR036417}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OIT35324.1}.
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DR   EMBL; MJEQ01000577; OIT35324.1; -; Genomic_DNA.
DR   RefSeq; XP_019266027.1; XM_019410482.1.
DR   AlphaFoldDB; A0A314L2X9; -.
DR   STRING; 49451.A0A314L2X9; -.
DR   EnsemblPlants; OIT35324; OIT35324; A4A49_22877.
DR   GeneID; 109243539; -.
DR   Gramene; OIT35324; OIT35324; A4A49_22877.
DR   KEGG; nau:109243539; -.
DR   OrthoDB; 720800at2759; -.
DR   UniPathway; UPA00094; -.
DR   Proteomes; UP000187609; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009922; F:fatty acid elongase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00831; CHS_like; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR012392; 3-ktacl-CoA_syn.
DR   InterPro; IPR013747; ACP_syn_III_C.
DR   InterPro; IPR013601; FAE1_typ3_polyketide_synth.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR31561; 3-KETOACYL-COA SYNTHASE; 1.
DR   PANTHER; PTHR31561:SF136; 3-KETOACYL-COA SYNTHASE; 1.
DR   Pfam; PF08541; ACP_syn_III_C; 1.
DR   Pfam; PF08392; FAE1_CUT1_RppA; 1.
DR   PIRSF; PIRSF036417; 3-ktacl-CoA_syn; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|PIRNR:PIRNR036417};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000187609};
KW   Transferase {ECO:0000256|PIRNR:PIRNR036417};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        64..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          81..367
FT                   /note="FAE"
FT                   /evidence="ECO:0000259|Pfam:PF08392"
FT   DOMAIN          384..464
FT                   /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08541"
SQ   SEQUENCE   491 AA;  54665 MW;  9F9ABE510A071543 CRC64;
     MAENAGEVCQ SNLPNFLLSI RLKYVKLGYH YLISNAVYLL IVPILAVVGF HLSTFTLENL
     MNHLAVLKSC STLVVFLTTV YIMSRPRNVY LVDFACYKPP QCFMTCKQGF IEKMSDILDE
     ESLNFLKKIS KRSGLGEKTY VPAESKIPSS VPMSTNQNEA KMVIIGAIDD LLAKTGVKVR
     EIGIVIVNSS AFNPTPSLSA MIVNHYKLGV NVITYNLGGM GCSAGLISVD LANRLLQGQA
     NSYALIATTE IISAGFYSGK LKSKLLSNCL FRMGASTALL SNRSYDRRRS KYQLMHVVRT
     HKGADDRAFN CAYLDEDEDG KKGISLSKDL MAVVGEALKT NITTLGPLVL PMSEQLLFLA
     SLIARKVFKR KIKPYIPDFK MAFEHFCIHA GGRAVLDELE KNLDLPEVLM EPSRMTLYRF
     GNTSSSSVWY NLAYSEAKGR IKKGDRAWQI GFGSGFKCNS VVWRALRTVD AAKEKNAWTY
     EIEDFPVRVT Y
//
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