ID A0A314L2X9_NICAT Unreviewed; 491 AA.
AC A0A314L2X9;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 08-NOV-2023, entry version 17.
DE RecName: Full=3-ketoacyl-CoA synthase {ECO:0000256|PIRNR:PIRNR036417};
DE EC=2.3.1.- {ECO:0000256|PIRNR:PIRNR036417};
GN Name=KCS2_0 {ECO:0000313|EMBL:OIT35324.1};
GN ORFNames=A4A49_22877 {ECO:0000313|EMBL:OIT35324.1};
OS Nicotiana attenuata (Coyote tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=49451 {ECO:0000313|EMBL:OIT35324.1, ECO:0000313|Proteomes:UP000187609};
RN [1] {ECO:0000313|EMBL:OIT35324.1, ECO:0000313|Proteomes:UP000187609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. UT {ECO:0000313|Proteomes:UP000187609};
RC TISSUE=Leaves {ECO:0000313|EMBL:OIT35324.1};
RA Xu S., Brockmoeller T., Gaquerel E., Navarro A., Kuhl H., Gase K., Ling Z.,
RA Zhou W., Kreitzer C., Stanke M., Tang H., Lyons E., Pandey P., Pandey S.P.,
RA Timmermann B., Baldwin I.T.;
RT "The genome of Nicotiana attenuata.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-
CC chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736;
CC EC=2.3.1.199; Evidence={ECO:0000256|ARBA:ARBA00001906};
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194, ECO:0000256|PIRNR:PIRNR036417}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC ECO:0000256|PIRNR:PIRNR036417}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIT35324.1}.
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DR EMBL; MJEQ01000577; OIT35324.1; -; Genomic_DNA.
DR RefSeq; XP_019266027.1; XM_019410482.1.
DR AlphaFoldDB; A0A314L2X9; -.
DR STRING; 49451.A0A314L2X9; -.
DR EnsemblPlants; OIT35324; OIT35324; A4A49_22877.
DR GeneID; 109243539; -.
DR Gramene; OIT35324; OIT35324; A4A49_22877.
DR KEGG; nau:109243539; -.
DR OrthoDB; 720800at2759; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000187609; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009922; F:fatty acid elongase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR012392; 3-ktacl-CoA_syn.
DR InterPro; IPR013747; ACP_syn_III_C.
DR InterPro; IPR013601; FAE1_typ3_polyketide_synth.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR31561; 3-KETOACYL-COA SYNTHASE; 1.
DR PANTHER; PTHR31561:SF136; 3-KETOACYL-COA SYNTHASE; 1.
DR Pfam; PF08541; ACP_syn_III_C; 1.
DR Pfam; PF08392; FAE1_CUT1_RppA; 1.
DR PIRSF; PIRSF036417; 3-ktacl-CoA_syn; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|PIRNR:PIRNR036417};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000187609};
KW Transferase {ECO:0000256|PIRNR:PIRNR036417};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 81..367
FT /note="FAE"
FT /evidence="ECO:0000259|Pfam:PF08392"
FT DOMAIN 384..464
FT /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08541"
SQ SEQUENCE 491 AA; 54665 MW; 9F9ABE510A071543 CRC64;
MAENAGEVCQ SNLPNFLLSI RLKYVKLGYH YLISNAVYLL IVPILAVVGF HLSTFTLENL
MNHLAVLKSC STLVVFLTTV YIMSRPRNVY LVDFACYKPP QCFMTCKQGF IEKMSDILDE
ESLNFLKKIS KRSGLGEKTY VPAESKIPSS VPMSTNQNEA KMVIIGAIDD LLAKTGVKVR
EIGIVIVNSS AFNPTPSLSA MIVNHYKLGV NVITYNLGGM GCSAGLISVD LANRLLQGQA
NSYALIATTE IISAGFYSGK LKSKLLSNCL FRMGASTALL SNRSYDRRRS KYQLMHVVRT
HKGADDRAFN CAYLDEDEDG KKGISLSKDL MAVVGEALKT NITTLGPLVL PMSEQLLFLA
SLIARKVFKR KIKPYIPDFK MAFEHFCIHA GGRAVLDELE KNLDLPEVLM EPSRMTLYRF
GNTSSSSVWY NLAYSEAKGR IKKGDRAWQI GFGSGFKCNS VVWRALRTVD AAKEKNAWTY
EIEDFPVRVT Y
//