ID A0A314ZRB8_PRUYE Unreviewed; 1165 AA.
AC A0A314ZRB8;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 28-JUN-2023, entry version 19.
DE RecName: Full=ABC-type xenobiotic transporter {ECO:0000256|ARBA:ARBA00012191};
DE EC=7.6.2.2 {ECO:0000256|ARBA:ARBA00012191};
GN ORFNames=Pyn_05379 {ECO:0000313|EMBL:PQQ21210.1};
OS Prunus yedoensis var. nudiflora.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=2094558 {ECO:0000313|EMBL:PQQ21210.1, ECO:0000313|Proteomes:UP000250321};
RN [1] {ECO:0000313|EMBL:PQQ21210.1, ECO:0000313|Proteomes:UP000250321}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Jeju island {ECO:0000313|Proteomes:UP000250321};
RC TISSUE=Leaf {ECO:0000313|EMBL:PQQ21210.1};
RA Baek S., Kim J.-H., Choi K., Kim G.-B., Cho A., Jang H., Shin C.-H.,
RA Yu H.-J., Mun J.-H.;
RT "Draft genome of wild Prunus yedoensis var. nudiflora.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate +
CC xenobioticSide 2.; EC=7.6.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00034018};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily.
CC {ECO:0000256|ARBA:ARBA00009726}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PQQ21210.1}.
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DR EMBL; PJQY01000017; PQQ21210.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A314ZRB8; -.
DR STRING; 2094558.A0A314ZRB8; -.
DR Proteomes; UP000250321; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR CDD; cd03244; ABCC_MRP_domain2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR044726; ABCC_6TM_D2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223:SF375; ABC TRANSPORTER C FAMILY MEMBER 11-RELATED; 1.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000250321};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 67..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 688..708
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..131
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 163..387
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 464..746
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 783..1017
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 392..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1165 AA; 129762 MW; AC9811930F2F7B25 CRC64;
MIPIQTIVIS KMRKLTKDGL QQTDKRVGLM NEILAAMDTV KCYAWETSFQ QRVQSIRNDE
LSRFRKAYLL SAFNSFILNS IPVVVTLTSF GMFTFLGGDL TPARAFTSLS LFAVLRFPLN
MLPNLLSQVV NANVSLQRLE ELFLTEERIL VPNQPLEPGL PAISIKDGYF SWDSKAEKPT
LSNINLDILV GSLVAVVGGT GEGKTSLVSA MLGELPPRAD SGVVIRGTVA YVPQVSWIFN
ATVRENVLFG SKFEPARYWK AIDLTELQHD LDILPGRDLT EIGERGVNIS GGQKQRVSMA
RAVYSNSDVY IFDDPLSALD AHVAKQVFNR CIKEELQGKT RVLVTNQLHF LPQVDQIILV
CDGTIKEVGT FKELSESSKV FQKLMENAGK MEEKEDSKND YHESSTPASN GVLNDLPNDV
SYAKKGKGAK SVLIKQEERE TGVVSWNILL RYKNALGGLW VVMVLFACYT LTEVLRVSSS
TWLSVWTAKS TSKSYKPGFY ILVYGILSFG QVIVTLTNSF WLITSSLRAA RRLHDALLNA
ILIAPMVFFH TTPTGRIINR FAKDLGDIDR MVANVMNMFL GQVWQLLSTF VLIGIVSTIS
LWAIMPLLIL FYAAYLFYQS TSREVKRLDS ITRSPVYAQF GEALNGLSSI RAYKAYDRMA
SISGRSMDNN IRFTLVNISS NRWLTIRLET LGGVMIWLIA TFAVMQNARA EDRVAFASTM
GLLLTYTLNI TNLLSSVLRQ ASRAENSLNA VERVGSYIEL PSEAPAVIES NRPRHGWPSA
GWIEFEDVVL RYRPGLPPVL HGLSFTVSAS EKLGIVGRTG AGKSSMINAL FRIVEIEKGR
ILIDSCDVSK VGLTDLRKVL SIIPQSPVLF SGTVRFNLDP FNEHNDADLW EALERAHLKD
VIRRNSLGLD AEVSEGGENF SVGQRQLISL ARALLRRSKI LVLDEATAAV DVRTDALIQK
TIREEFKSCT MLIIAHRLNT IIDCDQILVL DAGQVLEHDS PEKLLSNEES AFSKMVKSTG
PANAQYLCGL VFGGKQNKVV RDRTEPVVGQ SRRSWLASSR WAAAAQFALA ASLTASQKDL
QRSDIEDKNN ILMKTKDAVI TLQGVLEGKQ HKEIDNTLNQ HHIPRQGWWS AFFRIVEGMA
VMGRLAHNRL HPLEDDFEDK AIDWS
//
